Detail Information

Basic Information:


  VIRBase ID:  

HHID00048005

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5725

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:           ZFAND5:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30d-5p ZFAND5
miRBase
Accession/Entrez ID		 MIMAT0000245 7763
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ZA20D2//ZFAND5A//ZNF216

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30d-5p
rs1203910650 chr8:134804928    G/A
rs1244539439 chr8:134804930    G/T
rs1441595222 chr8:134804927    C/A
rs1441595222 chr8:134804927    C/T
rs374432132 chr8:134804931    G/A
rs776972352 chr8:134804925    G/A
rs1187386485 chr8:134804934    G/A
rs1373057893 chr8:134804937    TACA/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZFAND5
chr9:74968543(-) A-I      3'UTR
chr9:74967193(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZFAND5
chr9:74971252(-) A-I intron -    19478186
chr9:74966576(-) A-I exon 3'UTR    22327324

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZFAND5
chr9:74969373-74969374(-) m6A 3'UTR//exon       27773535
chr9:74969818-74969819(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:74969883-74969884(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:74969948-74969949(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:74970094-74970095(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:74970133-74970134(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr9:74970239-74970240(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr9:74970255-74970256(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr9:74970263-74970264(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:74970281-74970282(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:74970342-74970343(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:74970359-74970360(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr9:74970427-74970428(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr9:74970455-74970456(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr9:74970576-74970577(-) m6A 3'UTR//exon       24284625//24981863//26404942//27773535
chr9:74970601-74970602(-) m6A 3'UTR//exon       24981863//26404942//27773535
chr9:74970618-74970619(-) m6A 3'UTR//exon       24981863//26404942//27773535
chr9:74970811-74970812(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr9:74970843-74970844(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr9:74970849-74970850(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr9:74974351-74974352(-) m6A CDS//exon       -
chr9:74974371-74974372(-) m6A CDS//exon       -
chr9:74975067-74975068(-) m6A CDS//exon       -
chr9:74975079-74975080(-) m6A CDS//exon       -
chr9:74975444-74975445(-) m6A exon//intron       24981863//27371828
chr9:74975486-74975487(-) m6A exon//intron       24981863//27371828
chr9:74975499-74975500(-) m6A exon//intron       24981863//27371828
chr9:74975507-74975508(-) m6A exon//intron       24981863
chr9:74975521-74975522(-) m6A exon//intron       24981863
chr9:74975672-74975673(-) m6A CDS//exon       -
chr9:74975681-74975682(-) m6A CDS//exon       -
chr9:74978404-74978405(-) m6A 5'UTR//exon//intron       -
chr9:74978410-74978411(-) m6A 5'UTR//exon//intron       -
chr9:74978417-74978418(-) m6A 5'UTR//exon//intron       -
chr9:74978447-74978448(-) m6A 5'UTR//exon//intron       -
chr9:74978468-74978469(-) m6A 5'UTR//exon//intron       -
chr9:74979414-74979415(-) m6A 5'UTR//CDS//intron       27773536
chr9:74979542-74979543(-) m6A 5'UTR//intron       24209618//27773536
chr9:74979620-74979621(-) m6A 5'UTR//exon       24209618//27773536
chr9:74979640-74979641(-) m6A 5'UTR//exon       24209618//27773536
chr9:74979775-74979776(-) m6A 5'UTR//exon       24284625//27371828//27773536//22575960
chr9:74979785-74979786(-) m6A 5'UTR//exon       24284625//27371828//27773536//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30d-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome HCC tissues     30542726
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Cerebrospinal fluid     25420022
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
ZFAND5
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-30d-5p
Midostaurin 9829523 Drug resistant
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Antimycin A3 245869 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive
Kinetin riboside 20345 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
Cladospirone bisepoxide 10316810 Drug sensitive
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive
antineoplastic-d655481 - Drug resistant
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
isatin dr - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30d-5p
Gemcitabine 60750 Drug interaction    RC00001621
Sunitinib 5329102 Drug interaction    RC00001626
Eloxatine 5310940 Drug interaction    RC00001625
Trichostatin A 444732 Drug interaction    RC00001624
Paroxetine 43815 Drug interaction    RC00001620
Etoposide 36462 Drug interaction    RC00001619
5-Fluorouracil 3385 Drug interaction    RC00001617
Doxorubicin 31703 Drug interaction    RC00001618
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616
Verapamil 2520 Drug interaction    RC00001615
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627
Bicalutamide 2375 Drug interaction    RC00001614
Docetaxel 148124 Drug interaction    RC00001623
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628
Trastuzumab - Drug interaction    RC00001629
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-30d-5p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30d-5p
Interactor2: ZFAND5

Evidence Support:


Weak-Evidence HITS-CLIP//PAR-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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