Detail Information

Basic Information:


  VIRBase ID:  

HHID00047972

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:           NAP1L1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30d-5p NAP1L1
miRBase
Accession/Entrez ID		 MIMAT0000245 4673
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - NAP1//NAP1L//NRP

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30d-5p
rs1203910650 chr8:134804928    G/A
rs1244539439 chr8:134804930    G/T
rs1441595222 chr8:134804927    C/A
rs1441595222 chr8:134804927    C/T
rs374432132 chr8:134804931    G/A
rs776972352 chr8:134804925    G/A
rs1187386485 chr8:134804934    G/A
rs1373057893 chr8:134804937    TACA/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR NAP1L1
chr12:76470650(-) A-I      intronic
chr12:76450566(-) A-I      intronic
chr12:76445412(-) A-I      intronic
chr12:76475309(-) A-I      intronic
chr12:76473536(-) A-I      intronic
chr12:76450679(-) A-I      intronic
chr12:76473193(-) A-I      intronic
chr12:76452407(-) A-I      intronic
chr12:76450672(-) A-I      intronic
chr12:76451034(-) A-I      intronic
chr12:76451026(-) A-I      intronic
chr12:76450978(-) A-I      intronic
chr12:76450680(-) A-I      intronic
chr12:76473548(-) A-I      intronic
chr12:76473212(-) A-I      intronic
chr12:76464770(-) A-I      intronic
chr12:76450644(-) A-I      intronic
chr12:76473513(-) A-I      intronic
chr12:76473084(-) A-I      intronic
chr12:76445418(-) A-I      intronic
chr12:76452438(-) A-I      intronic
chr12:76450536(-) A-I      intronic
chr12:76464112(-) A-I      intronic
chr12:76464160(-) A-I      intronic
chr12:76471741(-) A-I      intronic
chr12:76445792(-) A-I      intronic
chr12:76451064(-) A-I      intronic
chr12:76473217(-) A-I      intronic
chr12:76473521(-) A-I      intronic
chr12:76450527(-) A-I      intronic
chr12:76451044(-) A-I      intronic
chr12:76452263(-) A-I      intronic
chr12:76452272(-) A-I      intronic
chr12:76452439(-) A-I      intronic
chr12:76450708(-) A-I      intronic
chr12:76445625(-) A-I      intronic
chr12:76445627(-) A-I      intronic
chr12:76473164(-) A-I      intronic
chr12:76452455(-) A-I      intronic
chr12:76450990(-) A-I      intronic
chr12:76450625(-) A-I      intronic
chr12:76473602(-) A-I      intronic
chr12:76452338(-) A-I      intronic
chr12:76447915(-) A-I      intronic
chr12:76473588(-) A-I      intronic
chr12:76473579(-) A-I      intronic
chr12:76452269(-) A-I      intronic
chr12:76473699(-) A-I      intronic
chr12:76473134(-) A-I      intronic
chr12:76445358(-) A-I      intronic
chr12:76445629(-) A-I      intronic
chr12:76464125(-) A-I      intronic
chr12:76473682(-) A-I      intronic
chr12:76452295(-) A-I      intronic
chr12:76473180(-) A-I      intronic
chr12:76452395(-) A-I      intronic
chr12:76473088(-) A-I      intronic
chr12:76450533(-) A-I      intronic
chr12:76473049(-) A-I      intronic
chr12:76470682(-) A-I      intronic
chr12:76450626(-) A-I      intronic
chr12:76452264(-) A-I      intronic
chr12:76470624(-) A-I      intronic
chr12:76450709(-) A-I      intronic
chr12:76473242(-) A-I      intronic
chr12:76470611(-) A-I      intronic
chr12:76473197(-) A-I      intronic
chr12:76450624(-) A-I      intronic
chr12:76471507(-) A-I      intronic
chr12:76470658(-) A-I      intronic
chr12:76473762(-) A-I      intronic
chr12:76474293(-) A-I      intronic
chr12:76445574(-) A-I      intronic
chr12:76452278(-) A-I      intronic
chr12:76450609(-) A-I      intronic
chr12:76473566(-) A-I      intronic
chr12:76470673(-) A-I      intronic
chr12:76452371(-) A-I      intronic
chr12:76474238(-) A-I      intronic
chr12:76470608(-) A-I      intronic
chr12:76471678(-) A-I      intronic
chr12:76452255(-) A-I      intronic
chr12:76450600(-) A-I      intronic
chr12:76473673(-) A-I      intronic
chr12:76450534(-) A-I      intronic
chr12:76464144(-) A-I      intronic
chr12:76474215(-) A-I      intronic
chr12:76451008(-) A-I      intronic
chr12:76454869(-) A-I      intronic
chr12:76474235(-) A-I      intronic
chr12:76474318(-) A-I      intronic
chr12:76452331(-) A-I      intronic
chr12:76474286(-) A-I      intronic
chr12:76475295(-) A-I      intronic
chr12:76470601(-) A-I      intronic
chr12:76452337(-) A-I      intronic
chr12:76474300(-) A-I      intronic
chr12:76471513(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED NAP1L1
chr12:76451511(-) A-I intron -    22327324
chr12:76470673(-) A-I intron -    22327324
chr12:76474215(-) A-I intron -    21960545   //22327324
chr12:76470624(-) A-I intron -    21960545
chr12:76470608(-) A-G intron -    22484847
chr12:76470611(-) A-G intron -    22484847
chr12:76470673(-) A-G intron -    22484847
chr12:76474215(-) A-G intron -    22484847
chr12:76474286(-) A-G intron -    22484847
chr12:76474293(-) A-G intron -    22484847
chr12:76474318(-) A-G intron -    22484847
chr12:76445418(-) A-G intron -    22484847
chr12:76445792(-) A-G intron -    22484847
chr12:76450527(-) A-G intron -    22484847
chr12:76450589(-) C-A intron -    22484847
chr12:76450609(-) A-G intron -    22484847
chr12:76450624(-) A-G intron -    22484847
chr12:76450625(-) A-G intron -    22484847
chr12:76450626(-) A-G intron -    22484847
chr12:76450644(-) A-G intron -    22484847
chr12:76451044(-) A-G intron -    22484847
chr12:76451064(-) A-G intron -    22484847
chr12:76452441(-) G-A intron -    22484847
chr12:76473164(-) A-G intron -    22484847
chr12:76473180(-) A-G intron -    22484847
chr12:76473197(-) A-G intron -    22484847
chr12:76473212(-) A-G intron -    22484847
chr12:76473242(-) A-G intron -    22484847
chr12:76473588(-) A-G intron -    22484847
chr12:76473682(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NAP1L1
chr12:76442159-76442160(-) m6A 3'UTR//intron       24981863//27773535//27371828
chr12:76442233-76442234(-) m6A 3'UTR//CDS//exon       25456834//24981863//28052920//27773535//27371828
chr12:76442788-76442789(-) m6A 3'UTR//intron       25456834//24981863//28052920//27773535//27371828
chr12:76442825-76442826(-) m6A 3'UTR//intron       25456834//24981863//28052920//27773535//27371828
chr12:76442992-76442993(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//22575960
chr12:76443041-76443042(-) m6A 3'UTR//exon//intron       24981863//28052920//27773535//22575960
chr12:76444401-76444402(-) m6A 3'UTR//CDS//exon       22575960
chr12:76448858-76448859(-) m6A CDS//exon       24981863
chr12:76448867-76448868(-) m6A CDS//exon       24981863
chr12:76449882-76449883(-) m6A 5'UTR//CDS//exon       24981863//28052920//27773535
chr12:76450049-76450050(-) m6A exon//intron       24981863//27773535
chr12:76450055-76450056(-) m6A exon//intron       27773535
chr12:76453526-76453527(-) m6A exon//intron       24981863
chr12:76453601-76453602(-) m6A 5'UTR//CDS//exon//intron       24981863//27773535//22575960
chr12:76453628-76453629(-) m6A 5'UTR//CDS//exon//intron       24981863//27773535//22575960
chr12:76454017-76454018(-) m6A 5'UTR//CDS//exon       22575960
chr12:76461172-76461173(-) m6A CDS//intron       22575960
chr12:76461191-76461192(-) m6A CDS//intron       22575960
chr12:76462695-76462696(-) m6A 5'UTR//CDS//exon//intron       24981863//27773535
chr12:76462700-76462701(-) m6A 5'UTR//CDS//exon//intron       24981863//27773535
chr12:76462712-76462713(-) m6A 5'UTR//CDS//exon//intron       24981863//27773535
chr12:76462720-76462721(-) m1A 5'UTR//CDS//exon//intron       26863410//26863196
chr12:76462729-76462730(-) m1A 5'UTR//CDS//exon//intron       26863410//26863196
chr12:76462758-76462759(-) m6A 5'UTR//CDS//exon//intron       24981863//27773535
chr12:76462767-76462768(-) m6A 5'UTR//CDS//exon//intron       24981863//27773535
chr12:76467588-76467589(-) m6A exon//intron       24981863//27773535
chr12:76467642-76467643(-) m6A exon//intron       27773535
chr12:76467991-76467992(-) m6A 5'UTR//CDS//exon//intron       24981863
chr12:76477675-76477676(-) m6A 5'UTR//intron       24981863//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30d-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome HCC tissues     30542726
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Cerebrospinal fluid     25420022
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
NAP1L1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-30d-5p
Midostaurin 9829523 Drug resistant
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Antimycin A3 245869 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive
Kinetin riboside 20345 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
Cladospirone bisepoxide 10316810 Drug sensitive
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive
antineoplastic-d655481 - Drug resistant
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
isatin dr - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30d-5p
Gemcitabine 60750 Drug interaction    RC00001621
Sunitinib 5329102 Drug interaction    RC00001626
Eloxatine 5310940 Drug interaction    RC00001625
Trichostatin A 444732 Drug interaction    RC00001624
Paroxetine 43815 Drug interaction    RC00001620
Etoposide 36462 Drug interaction    RC00001619
5-Fluorouracil 3385 Drug interaction    RC00001617
Doxorubicin 31703 Drug interaction    RC00001618
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616
Verapamil 2520 Drug interaction    RC00001615
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627
Bicalutamide 2375 Drug interaction    RC00001614
Docetaxel 148124 Drug interaction    RC00001623
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628
Trastuzumab - Drug interaction    RC00001629
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-30d-5p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30d-5p
Interactor2: NAP1L1

Evidence Support:


Weak-Evidence HITS-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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