Detail Information

Basic Information:


  VIRBase ID:  

HHID00047964

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5725

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:           JAK1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30d-5p JAK1
miRBase
Accession/Entrez ID		 MIMAT0000245 3716
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AIIDE//JAK1A//JAK1B//JTK3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30d-5p
rs1203910650 chr8:134804928    G/A
rs1244539439 chr8:134804930    G/T
rs1441595222 chr8:134804927    C/A
rs1441595222 chr8:134804927    C/T
rs374432132 chr8:134804931    G/A
rs776972352 chr8:134804925    G/A
rs1187386485 chr8:134804934    G/A
rs1373057893 chr8:134804937    TACA/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR JAK1
chr1:65382439(-) A-I      intronic
chr1:65382457(-) A-I      intronic
chr1:65382476(-) A-I      intronic
chr1:65382275(-) A-I      intronic
chr1:65380495(-) A-I      intronic
chr1:65380366(-) A-I      intronic
chr1:65417546(-) A-I      intronic
chr1:65419595(-) A-I      intronic
chr1:65425889(-) A-I      intronic
chr1:65425692(-) A-I      intronic
chr1:65425688(-) A-I      intronic
chr1:65419481(-) A-I      intronic
chr1:65406164(-) A-I      intronic
chr1:65406160(-) A-I      intronic
chr1:65406148(-) A-I      intronic
chr1:65398013(-) A-I      intronic
chr1:65411609(-) A-I      intronic
chr1:65411677(-) A-I      intronic
chr1:65417506(-) A-I      intronic
chr1:65417536(-) A-I      intronic
chr1:65417537(-) A-I      intronic
chr1:65409716(-) A-I      intronic
chr1:65382522(-) A-I      intronic
chr1:65406223(-) A-I      intronic
chr1:65397930(-) A-I      intronic
chr1:65397913(-) A-I      intronic
chr1:65397893(-) A-I      intronic
chr1:65406203(-) A-I      intronic
chr1:65406193(-) A-I      intronic
chr1:65382518(-) A-I      intronic
chr1:65419630(-) A-I      intronic
chr1:65406188(-) A-I      intronic
chr1:65419631(-) A-I      intronic
chr1:65423259(-) A-I      intronic
chr1:65409741(-) A-I      intronic
chr1:65409866(-) A-I      intronic
chr1:65406739(-) A-I      intronic
chr1:65315058(-) A-I      intronic
chr1:65417596(-) A-I      intronic
chr1:65406804(-) A-I      intronic
chr1:65382426(-) A-I      intronic
chr1:65382473(-) A-I      intronic
chr1:65406725(-) A-I      intronic
chr1:65406735(-) A-I      intronic
chr1:65406097(-) A-I      intronic
chr1:65398060(-) A-I      intronic
chr1:65419467(-) A-I      intronic
chr1:65401230(-) A-I      intronic
chr1:65406613(-) A-I      intronic
chr1:65406128(-) A-I      intronic
chr1:65406588(-) A-I      intronic
chr1:65326387(-) A-I      intronic
chr1:65406242(-) A-I      intronic
chr1:65406110(-) A-I      intronic
chr1:65428741(-) A-I      intronic
chr1:65406631(-) A-I      intronic
chr1:65406127(-) A-I      intronic
chr1:65406096(-) A-I      intronic
chr1:65401202(-) A-I      intronic
chr1:65351414(-) A-I      intronic
chr1:65406682(-) A-I      intronic
chr1:65346554(-) A-I      intronic
chr1:65406685(-) A-I      intronic
chr1:65406676(-) A-I      intronic
chr1:65423505(-) A-I      intronic
chr1:65417728(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED JAK1
chr1:65346554(-) A-G intron -    22484847
chr1:65401230(-) A-G intron -    22484847
chr1:65406613(-) A-G intron -    22484847
chr1:65406631(-) A-G intron -    22484847
chr1:65406682(-) A-G intron -    22484847
chr1:65406685(-) A-G intron -    22484847
chr1:65406725(-) A-G intron -    22484847
chr1:65406735(-) A-G intron -    22484847
chr1:65411671(-) G-A intron -    22484847
chr1:65416064(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase JAK1
chr1:65299215-65299216(-) m6A 3'UTR       26404942
chr1:65299232-65299233(-) m6A 3'UTR       26404942
chr1:65299253-65299254(-) m6A 3'UTR       26404942
chr1:65299483-65299484(-) m6A 3'UTR       26404942//27773535
chr1:65299496-65299497(-) m6A 3'UTR       26404942//27773535
chr1:65299543-65299544(-) m6A 3'UTR       26404942//27773535
chr1:65299671-65299672(-) m6A 3'UTR       24284625//26404942//27773535
chr1:65299677-65299678(-) m6A 3'UTR       24284625//26404942//27773535
chr1:65299758-65299759(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr1:65299795-65299796(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr1:65300062-65300063(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr1:65300122-65300123(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr1:65300278-65300279(-) m6A CDS       26404942
chr1:65300291-65300292(-) m6A CDS       26404942
chr1:65303629-65303630(-) m6A CDS       26404942
chr1:65305320-65305321(-) m6A CDS//exon       26404942
chr1:65305335-65305336(-) m6A CDS//exon       26404942
chr1:65305431-65305432(-) m6A CDS//exon       26404942
chr1:65306979-65306980(-) m6A CDS       26404942
chr1:65306996-65306997(-) m6A CDS       26404942
chr1:65307156-65307157(-) m6A CDS//exon       26404942//27773535
chr1:65307201-65307202(-) m6A CDS//exon       26404942//27773535
chr1:65309762-65309763(-) m6A CDS//exon       26404942//27773535
chr1:65313239-65313240(-) m6A CDS//exon       26404942
chr1:65313282-65313283(-) m6A CDS//exon       26404942//27773535
chr1:65313312-65313313(-) m6A CDS//exon       26404942//27773535
chr1:65313330-65313331(-) m6A CDS//exon       26404942//27773535
chr1:65321277-65321278(-) m6A CDS       22575960
chr1:65321301-65321302(-) m6A CDS       22575960
chr1:65321349-65321350(-) m6A CDS       22575960
chr1:65330554-65330555(-) m6A CDS       24981863
chr1:65330575-65330576(-) m6A CDS       24981863
chr1:65330598-65330599(-) m6A CDS       24981863//27371828
chr1:65330610-65330611(-) m6A CDS       24981863//27371828
chr1:65330625-65330626(-) m6A CDS       24981863//26404942//27371828
chr1:65332554-65332555(-) m6A CDS       24981863//26404942//27371828
chr1:65332676-65332677(-) m6A CDS       24981863//26404942//27371828//22608085
chr1:65332701-65332702(-) m6A CDS       24981863//26404942//27371828//22608085
chr1:65332712-65332713(-) m6A CDS       24981863//26404942//27371828//22608085
chr1:65332775-65332776(-) m6A CDS       26404942//22608085
chr1:65332840-65332841(-) m6A CDS       26404942
chr1:65332848-65332849(-) m6A CDS       26404942
chr1:65332868-65332869(-) m6A CDS       26404942
chr1:65334999-65335000(-) m6A CDS       26404942
chr1:65335010-65335011(-) m6A CDS       26404942
chr1:65335094-65335095(-) m6A CDS       26404942
chr1:65335108-65335109(-) m6A CDS       26404942
chr1:65335116-65335117(-) m6A CDS       26404942
chr1:65339180-65339181(-) m6A CDS       27773535
chr1:65341688-65341689(-) m6A exon//intron       27773535
chr1:65349033-65349034(-) m6A CDS       26404942
chr1:65349081-65349082(-) m6A CDS       26404942
chr1:65349091-65349092(-) m6A CDS       26404942
chr1:65349138-65349139(-) m6A CDS       26404942
chr1:65432181-65432182(-) m6A 5'UTR       24981863//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30d-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome HCC tissues     30542726
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Cerebrospinal fluid     25420022
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
JAK1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-30d-5p
Midostaurin 9829523 Drug resistant
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Antimycin A3 245869 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive
Kinetin riboside 20345 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
Cladospirone bisepoxide 10316810 Drug sensitive
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive
antineoplastic-d655481 - Drug resistant
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
isatin dr - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30d-5p
Gemcitabine 60750 Drug interaction    RC00001621
Sunitinib 5329102 Drug interaction    RC00001626
Eloxatine 5310940 Drug interaction    RC00001625
Trichostatin A 444732 Drug interaction    RC00001624
Paroxetine 43815 Drug interaction    RC00001620
Etoposide 36462 Drug interaction    RC00001619
5-Fluorouracil 3385 Drug interaction    RC00001617
Doxorubicin 31703 Drug interaction    RC00001618
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616
Verapamil 2520 Drug interaction    RC00001615
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627
Bicalutamide 2375 Drug interaction    RC00001614
Docetaxel 148124 Drug interaction    RC00001623
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628
Trastuzumab - Drug interaction    RC00001629
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-30d-5p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30d-5p
Interactor2: JAK1

Evidence Support:


Weak-Evidence HITS-CLIP//PAR-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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