Basic Information:

  VIRBase ID:  

HHID00047960

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:  MIMAT0000245          IFNAR2:  NM_001289126     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30d-5p	IFNAR2
miRBase Accession/Entrez ID	MIMAT0000245	3455
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	IFN-alpha-REC//IFN-R//IFNABR//IFNARB//IMD45

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30d-5p	rs1203910650 chr8:134804928    G/A rs1244539439 chr8:134804930    G/T rs1441595222 chr8:134804927    C/A rs1441595222 chr8:134804927    C/T rs374432132 chr8:134804931    G/A rs776972352 chr8:134804925    G/A rs1187386485 chr8:134804934    G/A rs1373057893 chr8:134804937    TACA/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IFNAR2	chr21:34615537(+) A-I      intronic chr21:34615553(+) A-I      intronic chr21:34634870(+) A-I      NonSyn:Gln->Arg chr21:34634993(+) A-I      NonSyn:Lys->Arg chr21:34634881(+) A-I      NonSyn:Lys->Glu chr21:34637281(+) A-I      3'UTR chr21:34637136(+) A-I      3'UTR chr21:34637065(+) A-I      3'UTR chr21:34634980(+) A-I      NonSyn:Ser->Gly chr21:34604212(+) A-I      intronic chr21:34637181(+) A-I      3'UTR chr21:34615235(+) A-I      intronic chr21:34615220(+) A-I      intronic chr21:34634619(+) A-I      intronic chr21:34634610(+) A-I      intronic chr21:34634589(+) A-I      intronic chr21:34634580(+) A-I      intronic chr21:34634469(+) A-I      intronic chr21:34634133(+) A-I      intronic chr21:34634038(+) A-I      intronic chr21:34624313(+) A-I      intronic chr21:34624238(+) A-I      intronic chr21:34624217(+) A-I      intronic chr21:34609680(+) A-I      intronic chr21:34615173(+) A-I      intronic chr21:34614884(+) A-I      intronic chr21:34608110(+) A-I      intronic chr21:34615193(+) A-I      intronic chr21:34615412(+) A-I      intronic chr21:34615549(+) A-I      intronic chr21:34634856(+) A-I      intronic chr21:34624295(+) A-I      intronic chr21:34622969(+) A-I      intronic chr21:34622982(+) A-I      intronic chr21:34623000(+) A-I      intronic chr21:34624154(+) A-I      intronic chr21:34624163(+) A-I      intronic chr21:34624211(+) A-I      intronic chr21:34614959(+) A-I      intronic chr21:34614923(+) A-I      intronic chr21:34614958(+) A-I      intronic chr21:34608116(+) A-I      intronic chr21:34637207(+) A-I      3'UTR chr21:34637142(+) A-I      3'UTR chr21:34636426(+) A-I      3'UTR chr21:34636386(+) A-I      3'UTR chr21:34637022(+) A-I      3'UTR chr21:34637061(+) A-I      3'UTR chr21:34637165(+) A-I      3'UTR chr21:34637087(+) A-I      3'UTR chr21:34637116(+) A-I      3'UTR chr21:34637278(+) A-I      3'UTR chr21:34637098(+) A-I      3'UTR chr21:34636393(+) A-I      3'UTR chr21:34637241(+) A-I      3'UTR chr21:34637095(+) A-I      3'UTR chr21:34637137(+) A-I      3'UTR chr21:34636399(+) A-I      3'UTR chr21:34637205(+) A-I      3'UTR chr21:34637115(+) A-I      3'UTR chr21:34636239(+) A-I      3'UTR chr21:34637110(+) A-I      3'UTR chr21:34637245(+) A-I      3'UTR chr21:34636349(+) A-I      3'UTR chr21:34636344(+) A-I      3'UTR chr21:34636351(+) A-I      3'UTR chr21:34637108(+) A-I      3'UTR chr21:34636215(+) A-I      3'UTR chr21:34637266(+) A-I      3'UTR chr21:34636328(+) A-I      3'UTR chr21:34636319(+) A-I      3'UTR chr21:34636353(+) A-I      3'UTR chr21:34637198(+) A-I      3'UTR chr21:34637251(+) A-I      3'UTR chr21:34636316(+) A-I      3'UTR chr21:34637192(+) A-I      3'UTR chr21:34637150(+) A-I      3'UTR chr21:34636305(+) A-I      3'UTR chr21:34636242(+) A-I      3'UTR chr21:34637224(+) A-I      3'UTR chr21:34634968(+) A-I      NonSyn:Ser->Gly chr21:34637185(+) A-I      3'UTR chr21:34636425(+) A-I      3'UTR chr21:34636364(+) A-I      3'UTR chr21:34636179(+) A-I      3'UTR chr21:34615194(+) A-I      intronic chr21:34615353(+) A-I      intronic chr21:34634439(+) A-I      intronic chr21:34633468(+) A-I      intronic chr21:34633965(+) A-I      intronic chr21:34604186(+) A-I      intronic chr21:34615367(+) A-I      intronic chr21:34604250(+) A-I      intronic chr21:34621518(+) A-I      intronic chr21:34633981(+) A-I      intronic chr21:34634050(+) A-I      intronic chr21:34615018(+) A-I      intronic chr21:34620550(+) A-I      intronic chr21:34614850(+) A-I      intronic chr21:34614782(+) A-I      intronic chr21:34621581(+) A-I      intronic chr21:34604227(+) A-I      intronic chr21:34615233(+) A-I      intronic chr21:34614891(+) A-I      intronic chr21:34615631(+) A-I      intronic chr21:34612870(+) A-I      intronic chr21:34615356(+) A-I      intronic chr21:34633542(+) A-I      intronic chr21:34612931(+) A-I      intronic chr21:34613077(+) A-I      intronic chr21:34633604(+) A-I      intronic chr21:34604224(+) A-I      intronic chr21:34633467(+) A-I      intronic chr21:34622861(+) A-I      intronic chr21:34613040(+) A-I      intronic chr21:34615198(+) A-I      intronic chr21:34634447(+) A-I      intronic chr21:34634486(+) A-I      intronic chr21:34634438(+) A-I      intronic chr21:34630590(+) A-I      intronic chr21:34634443(+) A-I      intronic chr21:34634514(+) A-I      intronic chr21:34633483(+) A-I      intronic chr21:34637140(+) A-I      3'UTR chr21:34637216(+) A-I      3'UTR chr21:34636385(+) A-I      3'UTR chr21:34636204(+) A-I      3'UTR chr21:34636260(+) A-I      3'UTR chr21:34636253(+) A-I      3'UTR chr21:34636259(+) A-I      3'UTR chr21:34637079(+) A-I      3'UTR chr21:34637145(+) A-I      3'UTR chr21:34636203(+) A-I      3'UTR chr21:34637159(+) A-I      3'UTR chr21:34636293(+) A-I      3'UTR chr21:34637246(+) A-I      3'UTR chr21:34637144(+) A-I      3'UTR chr21:34637208(+) A-I      3'UTR chr21:34636181(+) A-I      3'UTR chr21:34637084(+) A-I      3'UTR chr21:34637093(+) A-I      3'UTR chr21:34637237(+) A-I      3'UTR chr21:34636183(+) A-I      3'UTR chr21:34637149(+) A-I      3'UTR chr21:34637146(+) A-I      3'UTR chr21:34633947(+) A-I      intronic chr21:34608044(+) A-I      intronic chr21:34604281(+) A-I      intronic chr21:34609693(+) A-I      intronic chr21:34612862(+) A-I      intronic chr21:34622898(+) A-I      intronic chr21:34612914(+) A-I      intronic chr21:34613000(+) A-I      intronic chr21:34615376(+) A-I      intronic chr21:34614783(+) A-I      intronic chr21:34615408(+) A-I      intronic chr21:34623124(+) A-I      intronic chr21:34615114(+) A-I      intronic chr21:34604147(+) A-I      intronic chr21:34614888(+) A-I      intronic chr21:34634414(+) A-I      intronic chr21:34615303(+) A-I      intronic chr21:34615163(+) A-I      intronic chr21:34604071(+) A-I      intronic chr21:34612871(+) A-I      intronic chr21:34615514(+) A-I      intronic chr21:34615428(+) A-I      intronic chr21:34614881(+) A-I      intronic chr21:34612988(+) A-I      intronic chr21:34633435(+) A-I      intronic chr21:34634395(+) A-I      intronic chr21:34612990(+) A-I      intronic chr21:34609729(+) A-I      intronic chr21:34612929(+) A-I      intronic chr21:34615572(+) A-I      intronic chr21:34623033(+) A-I      intronic chr21:34633422(+) A-I      intronic chr21:34613101(+) A-I      intronic chr21:34609719(+) A-I      intronic chr21:34633999(+) A-I      intronic chr21:34633551(+) A-I      intronic chr21:34615284(+) A-I      intronic chr21:34613014(+) A-I      intronic chr21:34634122(+) A-I      intronic chr21:34615283(+) A-I      intronic chr21:34604254(+) A-I      intronic chr21:34621528(+) A-I      intronic chr21:34615662(+) A-I      intronic chr21:34623118(+) A-I      intronic chr21:34612973(+) A-I      intronic chr21:34615016(+) A-I      intronic chr21:34621394(+) A-I      intronic chr21:34633411(+) A-I      intronic chr21:34634034(+) A-I      intronic chr21:34604072(+) A-I      intronic chr21:34615021(+) A-I      intronic chr21:34615126(+) A-I      intronic chr21:34615617(+) A-I      intronic chr21:34623087(+) A-I      intronic chr21:34634042(+) A-I      intronic chr21:34612985(+) A-I      intronic chr21:34621569(+) A-I      intronic chr21:34614917(+) A-I      intronic chr21:34615563(+) A-I      intronic chr21:34634952(+) A-I      Syn:Lys->Lys chr21:34634882(+) A-I      NonSyn:Lys->Arg

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	IFNAR2	chr21:34621070(+) A-I exon CDS    15342557 chr21:34636203(+) A-I exon 3'UTR    15258596 chr21:34636234(+) A-I exon 3'UTR    15342557   //15258596 chr21:34636253(+) A-I exon 3'UTR    15342557   //15258596   //22327324 chr21:34636259(+) A-I exon 3'UTR    15342557   //15258596   //22327324 chr21:34636260(+) A-I exon 3'UTR    15342557   //15258596   //22327324 chr21:34636347(+) A-I exon 3'UTR    15258596 chr21:34636361(+) A-I exon 3'UTR    15342557   //15258596 chr21:34636384(+) A-I exon 3'UTR    15342557   //15258596   //22327324 chr21:34604071(+) A-I intron -    21960545   //22327324 chr21:34612928(+) A-I intron -    22327324 chr21:34612933(+) A-I intron -    22327324 chr21:34612973(+) A-I intron -    22327324 chr21:34612990(+) A-I intron -    22327324 chr21:34613040(+) A-I intron -    22327324 chr21:34636204(+) A-I intron -    22327324 chr21:34636293(+) A-I intron -    22327324 chr21:34636303(+) A-I intron -    22327324 chr21:34636385(+) A-I intron -    22327324 chr21:34604072(+) A-I intron -    21960545 chr21:34604127(+) A-I intron -    21960545 chr21:34604181(+) A-I intron -    21960545 chr21:34604250(+) A-I intron -    21960545 chr21:34612929(+) A-I intron -    21960545 chr21:34631036(+) A-I intron -    21960545 chr21:34604071(+) A-G intron -    22484847 chr21:34604072(+) A-G intron -    22484847 chr21:34604188(+) A-G intron -    22484847 chr21:34604224(+) A-G intron -    22484847 chr21:34604227(+) A-G intron -    22484847 chr21:34604250(+) A-G intron -    22484847 chr21:34604281(+) A-G intron -    22484847 chr21:34604313(+) A-G intron -    22484847 chr21:34608044(+) A-G intron -    22484847 chr21:34609760(+) A-G intron -    22484847 chr21:34609765(+) A-G intron -    22484847 chr21:34612928(+) A-G intron -    22484847 chr21:34612929(+) A-G intron -    22484847 chr21:34612931(+) A-G intron -    22484847 chr21:34612933(+) A-G intron -    22484847 chr21:34612973(+) A-G intron -    22484847 chr21:34612988(+) A-G intron -    22484847 chr21:34612990(+) A-G intron -    22484847 chr21:34613040(+) A-G intron -    22484847 chr21:34613119(+) C-A intron -    22484847 chr21:34615578(+) A-G intron -    22484847 chr21:34615650(+) A-G intron -    22484847 chr21:34620550(+) A-G intron -    22484847 chr21:34633399(+) T-C intron -    22484847 chr21:34633965(+) A-G intron -    22484847 chr21:34634074(+) A-G intron -    22484847 chr21:34634122(+) A-G intron -    22484847 chr21:34634176(+) A-G intron -    22484847 chr21:34634395(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IFNAR2	chr21:34635049-34635050(+) m6A 3'UTR//intron       - chr21:34635067-34635068(+) m6A 3'UTR//intron       - chr21:34635250-34635251(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635279-34635280(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635338-34635339(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635404-34635405(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635423-34635424(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635467-34635468(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635485-34635486(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635533-34635534(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635539-34635540(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635572-34635573(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635659-34635660(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635685-34635686(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635812-34635813(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr21:34635824-34635825(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr21:34635830-34635831(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr21:34635919-34635920(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr21:34635975-34635976(+) m6A 3'UTR       24981863//22608085 chr21:34636350-34636351(+) m6A 3'UTR       24209618 chr21:34636385-34636386(+) m6A 3'UTR       24209618 chr21:34636610-34636611(+) m6A 3'UTR       24209618//24981863//27773535 chr21:34636729-34636730(+) m6A 3'UTR       24209618//24981863 chr21:34636770-34636771(+) m6A 3'UTR       24981863//27773535 chr21:34636795-34636796(+) m6A 3'UTR       24981863//27773535 chr21:34636835-34636836(+) m6A 3'UTR       24981863//27773535 chr21:34636888-34636889(+) m6A 3'UTR       24209618//24981863//27773535 chr21:34637062-34637063(+) m6A 3'UTR       - chr21:34637094-34637095(+) m6A 3'UTR       - chr21:34637131-34637132(+) m6A 3'UTR       - chr21:34637352-34637353(+) m6A 3'UTR       24284625 chr21:34637358-34637359(+) m6A 3'UTR       24284625 chr21:34637458-34637459(+) m6A 3'UTR       24981863//22608085 chr21:34637484-34637485(+) m6A 3'UTR       24981863//22608085 chr21:34637519-34637520(+) m6A 3'UTR       24981863//22608085 chr21:34637578-34637579(+) m6A 3'UTR       24981863//22608085 chr21:34637624-34637625(+) m6A 3'UTR       24981863 chr21:34637656-34637657(+) m6A 3'UTR       24981863//26404942 chr21:34637686-34637687(+) m6A 3'UTR       24981863//26404942 chr21:34637741-34637742(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30d-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome HCC tissues     30542726 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Cerebrospinal fluid     25420022 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	IFNAR2	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-30d-5p	Midostaurin 9829523 Drug resistant Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive 2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Antimycin A3 245869 Drug sensitive 5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive 4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive Kinetin riboside 20345 Drug resistant Astrazon Orange R 135747272 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive (3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive antineoplastic-d655481 - Drug resistant 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive isatin dr - Drug sensitive tetra(isobutenyl)antimony bromide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30d-5p	Gemcitabine 60750 Drug interaction    RC00001621 Sunitinib 5329102 Drug interaction    RC00001626 Eloxatine 5310940 Drug interaction    RC00001625 Trichostatin A 444732 Drug interaction    RC00001624 Paroxetine 43815 Drug interaction    RC00001620 Etoposide 36462 Drug interaction    RC00001619 5-Fluorouracil 3385 Drug interaction    RC00001617 Doxorubicin 31703 Drug interaction    RC00001618 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616 Verapamil 2520 Drug interaction    RC00001615 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627 Bicalutamide 2375 Drug interaction    RC00001614 Docetaxel 148124 Drug interaction    RC00001623 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628 Trastuzumab - Drug interaction    RC00001629

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30d-5p	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30d-5p
Interactor2: IFNAR2

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).