Basic Information:

  VIRBase ID:  

HHID00047953

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:  MIMAT0000245          FUCA1:  NM_000147     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30d-5p	FUCA1
miRBase Accession/Entrez ID	MIMAT0000245	2517
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	FUCA

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30d-5p	rs1203910650 chr8:134804928    G/A rs1244539439 chr8:134804930    G/T rs1441595222 chr8:134804927    C/A rs1441595222 chr8:134804927    C/T rs374432132 chr8:134804931    G/A rs776972352 chr8:134804925    G/A rs1187386485 chr8:134804934    G/A rs1373057893 chr8:134804937    TACA/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FUCA1	chr1:24172936(-) A-I      intronic chr1:24188831(-) A-I      intronic chr1:24187324(-) A-I      intronic chr1:24176583(-) A-I      intronic chr1:24172957(-) A-I      intronic chr1:24172943(-) A-I      intronic chr1:24172939(-) A-I      intronic chr1:24172905(-) A-I      intronic chr1:24188852(-) A-I      intronic chr1:24188836(-) A-I      intronic chr1:24188816(-) A-I      intronic chr1:24188835(-) A-I      intronic chr1:24188833(-) A-I      intronic chr1:24188832(-) A-I      intronic chr1:24176272(-) A-I      intronic chr1:24176274(-) A-I      intronic chr1:24176350(-) A-I      intronic chr1:24176560(-) A-I      intronic chr1:24176561(-) A-I      intronic chr1:24176236(-) A-I      intronic chr1:24176649(-) A-I      intronic chr1:24176634(-) A-I      intronic chr1:24176625(-) A-I      intronic chr1:24176622(-) A-I      intronic chr1:24176602(-) A-I      intronic chr1:24176584(-) A-I      intronic chr1:24176237(-) A-I      intronic chr1:24176249(-) A-I      intronic chr1:24173196(-) A-I      intronic chr1:24172993(-) A-I      intronic chr1:24172845(-) A-I      intronic chr1:24177744(-) A-I      intronic chr1:24191413(-) A-I      intronic chr1:24191306(-) A-I      intronic chr1:24185973(-) A-I      intronic chr1:24173461(-) A-I      intronic chr1:24174449(-) A-I      intronic chr1:24174450(-) A-I      intronic chr1:24185944(-) A-I      intronic chr1:24185894(-) A-I      intronic chr1:24185827(-) A-I      intronic chr1:24185813(-) A-I      intronic chr1:24185800(-) A-I      intronic chr1:24185471(-) A-I      intronic chr1:24184762(-) A-I      intronic chr1:24184758(-) A-I      intronic chr1:24184752(-) A-I      intronic chr1:24183438(-) A-I      intronic chr1:24177771(-) A-I      intronic chr1:24177768(-) A-I      intronic chr1:24177742(-) A-I      intronic chr1:24177730(-) A-I      intronic chr1:24177366(-) A-I      intronic chr1:24176255(-) A-I      intronic chr1:24175601(-) A-I      intronic chr1:24175605(-) A-I      intronic chr1:24175657(-) A-I      intronic chr1:24176201(-) A-I      intronic chr1:24174368(-) A-I      intronic chr1:24175526(-) A-I      intronic chr1:24187267(-) A-I      intronic chr1:24184846(-) A-I      intronic chr1:24175611(-) A-I      intronic chr1:24172980(-) A-I      intronic chr1:24191359(-) A-I      intronic chr1:24185939(-) A-I      intronic chr1:24178773(-) A-I      intronic chr1:24177388(-) A-I      intronic chr1:24176300(-) A-I      intronic chr1:24185874(-) A-I      intronic chr1:24185956(-) A-I      intronic chr1:24177365(-) A-I      intronic chr1:24185330(-) A-I      intronic chr1:24185290(-) A-I      intronic chr1:24176684(-) A-I      intronic chr1:24173049(-) A-I      intronic chr1:24184119(-) A-I      intronic chr1:24177111(-) A-I      intronic chr1:24184085(-) A-I      intronic chr1:24172840(-) A-I      intronic chr1:24178795(-) A-I      intronic chr1:24172925(-) A-I      intronic chr1:24191472(-) A-I      intronic chr1:24176724(-) A-I      intronic chr1:24185300(-) A-I      intronic chr1:24176706(-) A-I      intronic chr1:24187218(-) A-I      intronic chr1:24175757(-) A-I      intronic chr1:24190298(-) A-I      intronic chr1:24190260(-) A-I      intronic chr1:24185313(-) A-I      intronic chr1:24177734(-) A-I      intronic chr1:24174476(-) A-I      intronic chr1:24172934(-) A-I      intronic chr1:24184852(-) A-I      intronic chr1:24186817(-) A-I      intronic chr1:24185491(-) A-I      intronic chr1:24173040(-) A-I      intronic chr1:24187275(-) A-I      intronic chr1:24186576(-) A-I      intronic chr1:24190798(-) A-I      intronic chr1:24175597(-) A-I      intronic chr1:24185553(-) A-I      intronic chr1:24187305(-) A-I      intronic chr1:24184693(-) A-I      intronic chr1:24177271(-) A-I      intronic chr1:24187325(-) A-I      intronic chr1:24190715(-) A-I      intronic chr1:24175678(-) A-I      intronic chr1:24185934(-) A-I      intronic chr1:24177548(-) A-I      intronic chr1:24178816(-) A-I      intronic chr1:24172940(-) A-I      intronic chr1:24187273(-) A-I      intronic chr1:24191474(-) A-I      intronic chr1:24187356(-) A-I      intronic chr1:24185993(-) A-I      intronic chr1:24187159(-) A-I      intronic chr1:24185413(-) A-I      intronic chr1:24190799(-) A-I      intronic chr1:24185544(-) A-I      intronic chr1:24190233(-) A-I      intronic chr1:24190311(-) A-I      intronic chr1:24190220(-) A-I      intronic chr1:24177732(-) A-I      intronic chr1:24190218(-) A-I      intronic chr1:24177360(-) A-I      intronic chr1:24188839(-) A-I      intronic chr1:24186034(-) A-I      intronic chr1:24178792(-) A-I      intronic chr1:24177682(-) A-I      intronic chr1:24177334(-) A-I      intronic chr1:24190741(-) A-I      intronic chr1:24186590(-) A-I      intronic chr1:24187393(-) A-I      intronic chr1:24177823(-) A-I      intronic chr1:24172921(-) A-I      intronic chr1:24187355(-) A-I      intronic chr1:24187221(-) A-I      intronic chr1:24190873(-) A-I      intronic chr1:24175679(-) A-I      intronic chr1:24190688(-) A-I      intronic chr1:24186597(-) A-I      intronic chr1:24184086(-) A-I      intronic chr1:24191333(-) A-I      intronic chr1:24187366(-) A-I      intronic chr1:24173200(-) A-I      intronic chr1:24175610(-) A-I      intronic chr1:24173245(-) A-I      intronic chr1:24177201(-) A-I      intronic chr1:24190850(-) A-I      intronic chr1:24172960(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FUCA1	chr1:24172980(-) A-G intron -    22484847 chr1:24174368(-) A-G intron -    22484847 chr1:24176724(-) A-G intron -    22484847 chr1:24177201(-) A-G intron -    22484847 chr1:24184119(-) A-G intron -    22484847 chr1:24184693(-) A-G intron -    22484847 chr1:24185939(-) A-G intron -    22484847 chr1:24185993(-) A-G intron -    22484847 chr1:24186034(-) A-G intron -    22484847 chr1:24187159(-) A-G intron -    22484847 chr1:24187273(-) A-G intron -    22484847 chr1:24187305(-) A-G intron -    22484847 chr1:24187325(-) A-G intron -    22484847 chr1:24190218(-) A-G intron -    22484847 chr1:24190220(-) A-G intron -    22484847 chr1:24190233(-) A-G intron -    22484847 chr1:24190298(-) A-G intron -    22484847 chr1:24190715(-) A-G intron -    22484847 chr1:24190798(-) A-G intron -    22484847 chr1:24190799(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FUCA1	chr1:24171966-24171967(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//22608085 chr1:24171979-24171980(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//22608085 chr1:24172035-24172036(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//22608085 chr1:24172065-24172066(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//22608085 chr1:24172117-24172118(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//22608085 chr1:24172230-24172231(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr1:24194657-24194658(-) m6A CDS       27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30d-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome HCC tissues     30542726 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Cerebrospinal fluid     25420022 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	FUCA1	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-30d-5p	Midostaurin 9829523 Drug resistant Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive 2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Antimycin A3 245869 Drug sensitive 5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive 4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive Kinetin riboside 20345 Drug resistant Astrazon Orange R 135747272 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive (3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive antineoplastic-d655481 - Drug resistant 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive isatin dr - Drug sensitive tetra(isobutenyl)antimony bromide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30d-5p	Gemcitabine 60750 Drug interaction    RC00001621 Sunitinib 5329102 Drug interaction    RC00001626 Eloxatine 5310940 Drug interaction    RC00001625 Trichostatin A 444732 Drug interaction    RC00001624 Paroxetine 43815 Drug interaction    RC00001620 Etoposide 36462 Drug interaction    RC00001619 5-Fluorouracil 3385 Drug interaction    RC00001617 Doxorubicin 31703 Drug interaction    RC00001618 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616 Verapamil 2520 Drug interaction    RC00001615 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627 Bicalutamide 2375 Drug interaction    RC00001614 Docetaxel 148124 Drug interaction    RC00001623 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628 Trastuzumab - Drug interaction    RC00001629

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30d-5p	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30d-5p
Interactor2: FUCA1

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).