Detail Information

Basic Information:


  VIRBase ID:  

HHID00047724

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5725

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30c-5p:           JAK1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30c-5p JAK1
miRBase
Accession/Entrez ID		 MIMAT0000244 3716
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AIIDE//JAK1A//JAK1B//JTK3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30c-5p
rs1273660120 chr1:40757310    C/G
rs757010411 chr1:40757312    A/G
rs778882994 chr1:40757318    T/G
rs113749278 chr6:71377017    A/G
rs113749278 chr6:71377017    A/T
rs1290581693 chr6:71377003    G/A
rs1296517452 chr6:71377016    G/T
rs1360882118 chr6:71377008    G/C
rs369489437 chr6:71377011    T/C
rs374192008 chr6:71377013    T/C
rs1357662785 chr6:71377024    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR JAK1
chr1:65382439(-) A-I      intronic
chr1:65382457(-) A-I      intronic
chr1:65382476(-) A-I      intronic
chr1:65382275(-) A-I      intronic
chr1:65380495(-) A-I      intronic
chr1:65380366(-) A-I      intronic
chr1:65417546(-) A-I      intronic
chr1:65419595(-) A-I      intronic
chr1:65425889(-) A-I      intronic
chr1:65425692(-) A-I      intronic
chr1:65425688(-) A-I      intronic
chr1:65419481(-) A-I      intronic
chr1:65406164(-) A-I      intronic
chr1:65406160(-) A-I      intronic
chr1:65406148(-) A-I      intronic
chr1:65398013(-) A-I      intronic
chr1:65411609(-) A-I      intronic
chr1:65411677(-) A-I      intronic
chr1:65417506(-) A-I      intronic
chr1:65417536(-) A-I      intronic
chr1:65417537(-) A-I      intronic
chr1:65409716(-) A-I      intronic
chr1:65382522(-) A-I      intronic
chr1:65406223(-) A-I      intronic
chr1:65397930(-) A-I      intronic
chr1:65397913(-) A-I      intronic
chr1:65397893(-) A-I      intronic
chr1:65406203(-) A-I      intronic
chr1:65406193(-) A-I      intronic
chr1:65382518(-) A-I      intronic
chr1:65419630(-) A-I      intronic
chr1:65406188(-) A-I      intronic
chr1:65419631(-) A-I      intronic
chr1:65423259(-) A-I      intronic
chr1:65409741(-) A-I      intronic
chr1:65409866(-) A-I      intronic
chr1:65406739(-) A-I      intronic
chr1:65315058(-) A-I      intronic
chr1:65417596(-) A-I      intronic
chr1:65406804(-) A-I      intronic
chr1:65382426(-) A-I      intronic
chr1:65382473(-) A-I      intronic
chr1:65406725(-) A-I      intronic
chr1:65406735(-) A-I      intronic
chr1:65406097(-) A-I      intronic
chr1:65398060(-) A-I      intronic
chr1:65419467(-) A-I      intronic
chr1:65401230(-) A-I      intronic
chr1:65406613(-) A-I      intronic
chr1:65406128(-) A-I      intronic
chr1:65406588(-) A-I      intronic
chr1:65326387(-) A-I      intronic
chr1:65406242(-) A-I      intronic
chr1:65406110(-) A-I      intronic
chr1:65428741(-) A-I      intronic
chr1:65406631(-) A-I      intronic
chr1:65406127(-) A-I      intronic
chr1:65406096(-) A-I      intronic
chr1:65401202(-) A-I      intronic
chr1:65351414(-) A-I      intronic
chr1:65406682(-) A-I      intronic
chr1:65346554(-) A-I      intronic
chr1:65406685(-) A-I      intronic
chr1:65406676(-) A-I      intronic
chr1:65423505(-) A-I      intronic
chr1:65417728(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED JAK1
chr1:65346554(-) A-G intron -    22484847
chr1:65401230(-) A-G intron -    22484847
chr1:65406613(-) A-G intron -    22484847
chr1:65406631(-) A-G intron -    22484847
chr1:65406682(-) A-G intron -    22484847
chr1:65406685(-) A-G intron -    22484847
chr1:65406725(-) A-G intron -    22484847
chr1:65406735(-) A-G intron -    22484847
chr1:65411671(-) G-A intron -    22484847
chr1:65416064(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase JAK1
chr1:65299215-65299216(-) m6A 3'UTR       26404942
chr1:65299232-65299233(-) m6A 3'UTR       26404942
chr1:65299253-65299254(-) m6A 3'UTR       26404942
chr1:65299483-65299484(-) m6A 3'UTR       26404942//27773535
chr1:65299496-65299497(-) m6A 3'UTR       26404942//27773535
chr1:65299543-65299544(-) m6A 3'UTR       26404942//27773535
chr1:65299671-65299672(-) m6A 3'UTR       24284625//26404942//27773535
chr1:65299677-65299678(-) m6A 3'UTR       24284625//26404942//27773535
chr1:65299758-65299759(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr1:65299795-65299796(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr1:65300062-65300063(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr1:65300122-65300123(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr1:65300278-65300279(-) m6A CDS       26404942
chr1:65300291-65300292(-) m6A CDS       26404942
chr1:65303629-65303630(-) m6A CDS       26404942
chr1:65305320-65305321(-) m6A CDS//exon       26404942
chr1:65305335-65305336(-) m6A CDS//exon       26404942
chr1:65305431-65305432(-) m6A CDS//exon       26404942
chr1:65306979-65306980(-) m6A CDS       26404942
chr1:65306996-65306997(-) m6A CDS       26404942
chr1:65307156-65307157(-) m6A CDS//exon       26404942//27773535
chr1:65307201-65307202(-) m6A CDS//exon       26404942//27773535
chr1:65309762-65309763(-) m6A CDS//exon       26404942//27773535
chr1:65313239-65313240(-) m6A CDS//exon       26404942
chr1:65313282-65313283(-) m6A CDS//exon       26404942//27773535
chr1:65313312-65313313(-) m6A CDS//exon       26404942//27773535
chr1:65313330-65313331(-) m6A CDS//exon       26404942//27773535
chr1:65321277-65321278(-) m6A CDS       22575960
chr1:65321301-65321302(-) m6A CDS       22575960
chr1:65321349-65321350(-) m6A CDS       22575960
chr1:65330554-65330555(-) m6A CDS       24981863
chr1:65330575-65330576(-) m6A CDS       24981863
chr1:65330598-65330599(-) m6A CDS       24981863//27371828
chr1:65330610-65330611(-) m6A CDS       24981863//27371828
chr1:65330625-65330626(-) m6A CDS       24981863//26404942//27371828
chr1:65332554-65332555(-) m6A CDS       24981863//26404942//27371828
chr1:65332676-65332677(-) m6A CDS       24981863//26404942//27371828//22608085
chr1:65332701-65332702(-) m6A CDS       24981863//26404942//27371828//22608085
chr1:65332712-65332713(-) m6A CDS       24981863//26404942//27371828//22608085
chr1:65332775-65332776(-) m6A CDS       26404942//22608085
chr1:65332840-65332841(-) m6A CDS       26404942
chr1:65332848-65332849(-) m6A CDS       26404942
chr1:65332868-65332869(-) m6A CDS       26404942
chr1:65334999-65335000(-) m6A CDS       26404942
chr1:65335010-65335011(-) m6A CDS       26404942
chr1:65335094-65335095(-) m6A CDS       26404942
chr1:65335108-65335109(-) m6A CDS       26404942
chr1:65335116-65335117(-) m6A CDS       26404942
chr1:65339180-65339181(-) m6A CDS       27773535
chr1:65341688-65341689(-) m6A exon//intron       27773535
chr1:65349033-65349034(-) m6A CDS       26404942
chr1:65349081-65349082(-) m6A CDS       26404942
chr1:65349091-65349092(-) m6A CDS       26404942
chr1:65349138-65349139(-) m6A CDS       26404942
chr1:65432181-65432182(-) m6A 5'UTR       24981863//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30c-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Human cervical cancer cell line (HeLa)     25760330
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Blood|B lymphoblastoid cells|Breast milk|Endothelial cells|Epithelial cells|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Colon adenocarcinoma cells     20864815
Nucleus Neural progenitor cells     21363885
JAK1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-30c-5p
2-Amino-3H-phenoxazin-3-one 72725 Drug resistant
Resorufin 69462 Drug resistant
Hopeaphenol 495605 Drug resistant
2,3-Dimethylbenzo[g]quinoxaline-5,10-dione 353644 Drug resistant
6,7-Dimethoxy-4-(3-hydroxy-4-methylanilino)quinazoline hydrochloride 21701565 Drug sensitive
Erlotinib 176870 Drug sensitive
(S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate 10437018 Drug sensitive
1,2-benzo-8-(d,l-alanyl)-3-phenoxazone nitrate salt - Drug resistant
2-chloro-3-amino-5,8-dihydoxy-1,4-naphthoquinone - Drug resistant
benzo[b]naphtho[2,3-d]furan-6,11-dione, 4-chloro-3-hydroxy - Drug resistant
organosulfur compound - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30c-5p
Curcumin 969516 Drug interaction    RC00001607
Vincristine 5978 Drug interaction    RC00001599
Estradiol 5757 Drug interaction    RC00001598
Mitomycin 5746 Drug interaction    RC00001597
Eloxatine 5310940 Drug interaction    RC00001609
Imatinib 5291 Drug interaction    RC00001596
Morphine 5288826 Drug interaction    RC00001608
Docosahexaenoic acid 445580 Drug interaction    RC00001606
Cyclopamine 442972 Drug interaction    RC00001605
Carboplatinum 38904 Drug interaction    RC00001603
Paclitaxel 36314 Drug interaction    RC00001602
Doxorubicin 31703 Drug interaction    RC00001601
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001595
Arsenic trioxide 14888 Drug interaction    RC00001600
Gefitinib 123631 Drug interaction    RC00001604
platinum-based doublet chemotherapy - Drug interaction    RC00001610
TRAIL therapy - Drug interaction    RC00001611
Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00001612
Trastuzumab - Drug interaction    RC00001613
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-30c-5p
Cisplatin 5702198       28222434

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30c-5p
Interactor2: JAK1

Evidence Support:


Weak-Evidence HITS-CLIP//PAR-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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