Basic Information:

  VIRBase ID:  

HHID00047626

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-199a-3p:  MIMAT0000232          OSBPL8:  NM_001319655     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-199a-3p	OSBPL8
miRBase Accession/Entrez ID	MIMAT0000232	114882
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MST120//MSTP120//ORP8//OSBP10

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-199a-3p	rs1244221007 chr19:10817432    C/G rs1281197836 chr19:10817437    G/A rs1315393563 chr19:10817435    A/G rs746524562 chr19:10817434    A/G rs746524562 chr19:10817434    A/T rs961039315 chr19:10817436    T/C rs990986317 chr19:10817442    G/A rs1161021809 chr1:172144560    A/G rs1482780016 chr19:10817448    T/C rs183664554 chr19:10817443    A/G rs771220698 chr19:10817447    C/T rs776326431 chr19:10817446    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	OSBPL8	chr12:76868675(-) A-I      intronic chr12:76868668(-) A-I      intronic chr12:76799163(-) A-I      intronic chr12:76790692(-) A-I      intronic chr12:76868684(-) A-I      intronic chr12:76868683(-) A-I      intronic chr12:76881029(-) A-I      intronic chr12:76881024(-) A-I      intronic chr12:76920725(-) A-I      intronic chr12:76921929(-) A-I      intronic chr12:76921938(-) A-I      intronic chr12:76921944(-) A-I      intronic chr12:76924037(-) A-I      intronic chr12:76924055(-) A-I      intronic chr12:76931526(-) A-I      intronic chr12:76931606(-) A-I      intronic chr12:76943315(-) A-I      intronic chr12:76943319(-) A-I      intronic chr12:76944745(-) A-I      intronic chr12:76950559(-) A-I      intronic chr12:76950581(-) A-I      intronic chr12:76950582(-) A-I      intronic chr12:76950640(-) A-I      intronic chr12:76950700(-) A-I      intronic chr12:76951227(-) A-I      intronic chr12:76951333(-) A-I      intronic chr12:76951338(-) A-I      intronic chr12:76877244(-) A-I      intronic chr12:76876311(-) A-I      intronic chr12:76877262(-) A-I      intronic chr12:76877306(-) A-I      intronic chr12:76877682(-) A-I      intronic chr12:76877688(-) A-I      intronic chr12:76877697(-) A-I      intronic chr12:76877744(-) A-I      intronic chr12:76878777(-) A-I      intronic chr12:76878786(-) A-I      intronic chr12:76878797(-) A-I      intronic chr12:76878812(-) A-I      intronic chr12:76878816(-) A-I      intronic chr12:76878865(-) A-I      intronic chr12:76878870(-) A-I      intronic chr12:76878880(-) A-I      intronic chr12:76878885(-) A-I      intronic chr12:76878953(-) A-I      intronic chr12:76878967(-) A-I      intronic chr12:76878982(-) A-I      intronic chr12:76879141(-) A-I      intronic chr12:76879241(-) A-I      intronic chr12:76879271(-) A-I      intronic chr12:76880878(-) A-I      intronic chr12:76880882(-) A-I      intronic chr12:76880948(-) A-I      intronic chr12:76880974(-) A-I      intronic chr12:76880978(-) A-I      intronic chr12:76881030(-) A-I      intronic chr12:76881038(-) A-I      intronic chr12:76881048(-) A-I      intronic chr12:76881084(-) A-I      intronic chr12:76892602(-) A-I      intronic chr12:76892656(-) A-I      intronic chr12:76892678(-) A-I      intronic chr12:76892684(-) A-I      intronic chr12:76893227(-) A-I      intronic chr12:76893396(-) A-I      intronic chr12:76893428(-) A-I      intronic chr12:76893450(-) A-I      intronic chr12:76901875(-) A-I      intronic chr12:76910687(-) A-I      intronic chr12:76910697(-) A-I      intronic chr12:76910700(-) A-I      intronic chr12:76910718(-) A-I      intronic chr12:76910773(-) A-I      intronic chr12:76772671(-) A-I      intronic chr12:76772706(-) A-I      intronic chr12:76772726(-) A-I      intronic chr12:76910782(-) A-I      intronic chr12:76774303(-) A-I      intronic chr12:76775630(-) A-I      intronic chr12:76775631(-) A-I      intronic chr12:76910861(-) A-I      intronic chr12:76918601(-) A-I      intronic chr12:76775765(-) A-I      intronic chr12:76775766(-) A-I      intronic chr12:76776555(-) A-I      intronic chr12:76918602(-) A-I      intronic chr12:76776563(-) A-I      intronic chr12:76790296(-) A-I      intronic chr12:76918646(-) A-I      intronic chr12:76790364(-) A-I      intronic chr12:76790406(-) A-I      intronic chr12:76790451(-) A-I      intronic chr12:76790465(-) A-I      intronic chr12:76790512(-) A-I      intronic chr12:76799075(-) A-I      intronic chr12:76799139(-) A-I      intronic chr12:76801198(-) A-I      intronic chr12:76801199(-) A-I      intronic chr12:76920550(-) A-I      intronic chr12:76920554(-) A-I      intronic chr12:76802142(-) A-I      intronic chr12:76811954(-) A-I      intronic chr12:76812049(-) A-I      intronic chr12:76812064(-) A-I      intronic chr12:76920569(-) A-I      intronic chr12:76831971(-) A-I      intronic chr12:76831972(-) A-I      intronic chr12:76831995(-) A-I      intronic chr12:76837514(-) A-I      intronic chr12:76837557(-) A-I      intronic chr12:76842538(-) A-I      intronic chr12:76842618(-) A-I      intronic chr12:76842649(-) A-I      intronic chr12:76842736(-) A-I      intronic chr12:76842755(-) A-I      intronic chr12:76842786(-) A-I      intronic chr12:76852442(-) A-I      intronic chr12:76858053(-) A-I      intronic chr12:76858067(-) A-I      intronic chr12:76872835(-) A-I      intronic chr12:76873702(-) A-I      intronic chr12:76876177(-) A-I      intronic chr12:76876149(-) A-I      intronic chr12:76841484(-) A-I      intronic chr12:76772674(-) A-I      intronic chr12:76943328(-) A-I      intronic chr12:76772753(-) A-I      intronic chr12:76877736(-) A-I      intronic chr12:76812035(-) A-I      intronic chr12:76790418(-) A-I      intronic chr12:76877658(-) A-I      intronic chr12:76877092(-) A-I      intronic chr12:76951312(-) A-I      intronic chr12:76879205(-) A-I      intronic chr12:76809244(-) A-I      intronic chr12:76920568(-) A-I      intronic chr12:76878873(-) A-I      intronic chr12:76944742(-) A-I      intronic chr12:76774246(-) A-I      intronic chr12:76880958(-) A-I      intronic chr12:76790448(-) A-I      intronic chr12:76812040(-) A-I      intronic chr12:76801147(-) A-I      intronic chr12:76879266(-) A-I      intronic chr12:76877560(-) A-I      intronic chr12:76877537(-) A-I      intronic chr12:76944738(-) A-I      intronic chr12:76946084(-) A-I      intronic chr12:76877687(-) A-I      intronic chr12:76892597(-) A-I      intronic chr12:76872676(-) A-I      intronic chr12:76774224(-) A-I      intronic chr12:76809292(-) A-I      intronic chr12:76877527(-) A-I      intronic chr12:76877507(-) A-I      intronic chr12:76831864(-) A-I      intronic chr12:76876310(-) A-I      intronic chr12:76892638(-) A-I      intronic chr12:76790410(-) A-I      intronic chr12:76944826(-) A-I      intronic chr12:76790870(-) A-I      intronic chr12:76826360(-) A-I      intronic chr12:76876891(-) A-I      intronic chr12:76809287(-) A-I      intronic chr12:76893288(-) A-I      intronic chr12:76878882(-) A-I      intronic chr12:76772655(-) A-I      intronic chr12:76879253(-) A-I      intronic chr12:76923912(-) A-I      intronic chr12:76879267(-) A-I      intronic chr12:76877599(-) A-I      intronic chr12:76801146(-) A-I      intronic chr12:76877592(-) A-I      intronic chr12:76877727(-) A-I      intronic chr12:76893539(-) A-I      intronic chr12:76794636(-) A-I      intronic chr12:76832189(-) A-I      intronic chr12:76842741(-) A-I      intronic chr12:76877287(-) A-I      intronic chr12:76841528(-) A-I      intronic chr12:76772629(-) A-I      intronic chr12:76877583(-) A-I      intronic chr12:76877346(-) A-I      intronic chr12:76879089(-) A-I      intronic chr12:76811926(-) A-I      intronic chr12:76893625(-) A-I      intronic chr12:76851849(-) A-I      intronic chr12:76920711(-) A-I      intronic chr12:76951273(-) A-I      intronic chr12:76811868(-) A-I      intronic chr12:76790755(-) A-I      intronic chr12:76878994(-) A-I      intronic chr12:76841488(-) A-I      intronic chr12:76880883(-) A-I      intronic chr12:76890635(-) A-I      intronic chr12:76923888(-) A-I      intronic chr12:76790452(-) A-I      intronic chr12:76879195(-) A-I      intronic chr12:76922071(-) A-I      intronic chr12:76790390(-) A-I      intronic chr12:76877222(-) A-I      intronic chr12:76920468(-) A-I      intronic chr12:76772647(-) A-I      intronic chr12:76951260(-) A-I      intronic chr12:76790754(-) A-I      intronic chr12:76831797(-) A-I      intronic chr12:76893283(-) A-I      intronic chr12:76772732(-) A-I      intronic chr12:76910624(-) A-I      intronic chr12:76880877(-) A-I      intronic chr12:76879149(-) A-I      intronic chr12:76950549(-) A-I      intronic chr12:76892610(-) A-I      intronic chr12:76876779(-) A-I      intronic chr12:76877692(-) A-I      intronic chr12:76892615(-) A-I      intronic chr12:76880906(-) A-I      intronic chr12:76879270(-) A-I      intronic chr12:76794634(-) A-I      intronic chr12:76808293(-) A-I      intronic chr12:76893512(-) A-I      intronic chr12:76879180(-) A-I      intronic chr12:76772688(-) A-I      intronic chr12:76855268(-) A-I      intronic chr12:76931501(-) A-I      intronic chr12:76893468(-) A-I      intronic chr12:76904497(-) A-I      intronic chr12:76880844(-) A-I      intronic chr12:76881106(-) A-I      intronic chr12:76868769(-) A-I      intronic chr12:76808512(-) A-I      intronic chr12:76880907(-) A-I      intronic chr12:76918728(-) A-I      intronic chr12:76920503(-) A-I      intronic chr12:76946094(-) A-I      intronic chr12:76808327(-) A-I      intronic chr12:76876892(-) A-I      intronic chr12:76879244(-) A-I      intronic chr12:76877098(-) A-I      intronic chr12:76799838(-) A-I      intronic chr12:76790697(-) A-I      intronic chr12:76877261(-) A-I      intronic chr12:76877176(-) A-I      intronic chr12:76951391(-) A-I      intronic chr12:76893374(-) A-I      intronic chr12:76776624(-) A-I      intronic chr12:76951229(-) A-I      intronic chr12:76877619(-) A-I      intronic chr12:76868657(-) A-I      intronic chr12:76877179(-) A-I      intronic chr12:76890258(-) A-I      intronic chr12:76880938(-) A-I      intronic chr12:76923905(-) A-I      intronic chr12:76842762(-) A-I      intronic chr12:76809223(-) A-I      intronic chr12:76880987(-) A-I      intronic chr12:76876995(-) A-I      intronic chr12:76922031(-) A-I      intronic chr12:76950540(-) A-I      intronic chr12:76878876(-) A-I      intronic chr12:76921932(-) A-I      intronic chr12:76841616(-) A-I      intronic chr12:76878868(-) A-I      intronic chr12:76832910(-) A-I      intronic chr12:76951283(-) A-I      intronic chr12:76877593(-) A-I      intronic chr12:76790425(-) A-I      intronic chr12:76944684(-) A-I      intronic chr12:76921846(-) A-I      intronic chr12:76868757(-) A-I      intronic chr12:76904494(-) A-I      intronic chr12:76910867(-) A-I      intronic chr12:76877108(-) A-I      intronic chr12:76878930(-) A-I      intronic chr12:76831483(-) A-I      intronic chr12:76877633(-) A-I      intronic chr12:76922001(-) A-I      intronic chr12:76921858(-) A-I      intronic chr12:76924117(-) A-I      intronic chr12:76774263(-) A-I      intronic chr12:76877728(-) A-I      intronic chr12:76893289(-) A-I      intronic chr12:76879258(-) A-I      intronic chr12:76812611(-) A-I      intronic chr12:76877520(-) A-I      intronic chr12:76950647(-) A-I      intronic chr12:76879186(-) A-I      intronic chr12:76877552(-) A-I      intronic chr12:76811923(-) A-I      intronic chr12:76915516(-) A-I      intronic chr12:76811924(-) A-I      intronic chr12:76950474(-) A-I      intronic chr12:76910731(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	OSBPL8	chr12:76876149(-) A-I intron -    15545495 chr12:76799838(-) A-G intron -    22484847 chr12:76877736(-) A-G intron -    22484847 chr12:76893289(-) A-G intron -    22484847 chr12:76766204(-) T-C intron -    22484847 chr12:76772674(-) A-G intron -    22484847 chr12:76772732(-) A-G intron -    22484847 chr12:76774246(-) A-G intron -    22484847 chr12:76774263(-) A-G intron -    22484847 chr12:76790390(-) A-G intron -    22484847 chr12:76790410(-) A-G intron -    22484847 chr12:76790418(-) A-G intron -    22484847 chr12:76790425(-) A-G intron -    22484847 chr12:76790452(-) A-G intron -    22484847 chr12:76790754(-) A-G intron -    22484847 chr12:76790755(-) A-G intron -    22484847 chr12:76790870(-) A-G intron -    22484847 chr12:76841484(-) A-G intron -    22484847 chr12:76841528(-) A-G intron -    22484847 chr12:76841616(-) A-G intron -    22484847 chr12:76842741(-) A-G intron -    22484847 chr12:76842762(-) A-G intron -    22484847 chr12:76855407(-) G-A intron -    22484847 chr12:76876310(-) A-G intron -    22484847 chr12:76877108(-) A-G intron -    22484847 chr12:76877261(-) A-G intron -    22484847 chr12:76877727(-) A-G intron -    22484847 chr12:76878873(-) A-G intron -    22484847 chr12:76878876(-) A-G intron -    22484847 chr12:76878994(-) A-G intron -    22484847 chr12:76879149(-) A-G intron -    22484847 chr12:76879195(-) A-G intron -    22484847 chr12:76879244(-) A-G intron -    22484847 chr12:76879253(-) A-G intron -    22484847 chr12:76921932(-) A-G intron -    22484847 chr12:76922071(-) A-G intron -    22484847 chr12:76931501(-) A-G intron -    22484847 chr12:76943328(-) A-G intron -    22484847 chr12:76944826(-) A-G intron -    22484847 chr12:76947278(-) A-T intron -    22484847 chr12:76950474(-) A-G intron -    22484847 chr12:76950540(-) A-G intron -    22484847 chr12:76950549(-) A-G intron -    22484847 chr12:76950647(-) A-G intron -    22484847 chr12:76951229(-) A-G intron -    22484847 chr12:76951260(-) A-G intron -    22484847 chr12:76951273(-) A-G intron -    22484847 chr12:76951283(-) A-G intron -    22484847 chr12:76951312(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	OSBPL8	chr12:76746081-76746082(-) m6A 3'UTR       27773535 chr12:76746129-76746130(-) m6A 3'UTR       27773535 chr12:76746148-76746149(-) m6A 3'UTR       27773535 chr12:76748437-76748438(-) Y 3'UTR       26075521 chr12:76749402-76749403(-) m6A 3'UTR       27773535 chr12:76749448-76749449(-) m6A 3'UTR       24981863//27773535//22608085 chr12:76749500-76749501(-) m6A 3'UTR       24981863//27773535//22608085 chr12:76749557-76749558(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr12:76749565-76749566(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr12:76749616-76749617(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr12:76749642-76749643(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr12:76749684-76749685(-) m6A CDS       24284625//24981863//27773535//22608085 chr12:76749729-76749730(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr12:76750428-76750429(-) m6A CDS       24284625//24981863//27773535//22608085 chr12:76750456-76750457(-) m6A CDS       24981863//27773535//22608085 chr12:76750464-76750465(-) m6A CDS       24981863//27773535//22608085 chr12:76750494-76750495(-) m6A CDS       24981863//27773535//22608085 chr12:76752502-76752503(-) m6A CDS       24981863//27773535 chr12:76752516-76752517(-) m6A CDS       24981863//27773535 chr12:76752570-76752571(-) m6A CDS       24981863//27773535 chr12:76763008-76763009(-) m6A CDS//exon       24981863//27773535 chr12:76763019-76763020(-) m6A CDS//exon       24981863//27773535 chr12:76763066-76763067(-) m6A CDS//exon       24981863//27773535 chr12:76765250-76765251(-) m6A CDS//exon       27773535 chr12:76765333-76765334(-) m6A CDS//exon       27773535 chr12:76784208-76784209(-) m6A CDS//exon       24981863//27773535//27371828 chr12:76784223-76784224(-) m6A CDS//exon       24981863//27773535//27371828 chr12:76784237-76784238(-) m6A CDS//exon       24981863//27773535//27371828//22575960 chr12:76784265-76784266(-) m6A CDS//exon       24981863//27773535//27371828//22575960 chr12:76784286-76784287(-) m6A CDS//exon       24981863//27773535//27371828//22575960 chr12:76784352-76784353(-) m6A CDS//exon       24981863//27773535//22575960 chr12:76784398-76784399(-) m6A CDS//exon       27773535//22575960 chr12:76786429-76786430(-) Cm CDS//exon       - chr12:76796534-76796535(-) m6A CDS       - chr12:76816309-76816310(-) m6A CDS//intron       - chr12:76844755-76844756(-) m6A 5'UTR//CDS//intron       27773535 chr12:76953216-76953217(-) m6A 5'UTR//exon       27773536 chr12:76953244-76953245(-) m6A 5'UTR//exon       27773536 chr12:76953402-76953403(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-199a-3p	Exosome Peripheral blood mononuclear cells     19002258 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Blood|Endothelial cells     - Extracellular Vesicle Liposarcoma cell lines (Lipo224B|Lipo246|Lipo863|LPS141)|Preadipocytes     28588009 Microvesicle Plasma     19002258 Microvesicle Plasma     23077538 Microvesicle Follicular fluid     23666971 Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849
	OSBPL8	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-199a-3p	Curcumin 969516 Drug interaction    RC00001534 Ethanol 702 Drug interaction    RC00001528 Gemcitabine 60750 Drug interaction    RC00001533 Enoxacin 3229 Drug interaction    RC00001530 Emodin 3220 Drug interaction    RC00001529 Doxorubicin 31703 Drug interaction    RC00001532 Arsenic trioxide 14888 Drug interaction    RC00001531

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-199a-3p	Cisplatin 5702198       26261572 Cisplatin 5702198       28126676 Cisplatin 5702198       28422725 Cisplatin 5702198       28743276 Cisplatin 5702198       29436681 Cisplatin 5702198       29866054 Carboplatin 426756       29866054 Doxorubicin 31703       20501828 Doxorubicin 31703       21055388 Doxorubicin 31703       26079799 Doxorubicin 31703       29866054 Docetaxel 148124       21807947

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-199a-3p
Interactor2: OSBPL8

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.