Detail Information

Basic Information:


  VIRBase ID:  

HHID00047557

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-197-3p:           TM9SF3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-197-3p TM9SF3
miRBase
Accession/Entrez ID		 MIMAT0000227 56889
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - EP70-P-iso//SMBP

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-197-3p
rs1346135890 chr1:109598940    T/A
rs1421064771 chr1:109598954    C/T
rs1427063395 chr1:109598952    T/G
rs142872331 chr1:109598956    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TM9SF3
chr10:98300788(-) A-I      intronic
chr10:98300785(-) A-I      intronic
chr10:98300794(-) A-I      intronic
chr10:98300793(-) A-I      intronic
chr10:98329677(-) A-I      intronic
chr10:98323987(-) A-I      intronic
chr10:98340218(-) A-I      intronic
chr10:98330623(-) A-I      intronic
chr10:98322887(-) A-I      intronic
chr10:98322956(-) A-I      intronic
chr10:98340083(-) A-I      intronic
chr10:98330768(-) A-I      intronic
chr10:98340207(-) A-I      intronic
chr10:98338622(-) A-I      intronic
chr10:98338665(-) A-I      intronic
chr10:98338671(-) A-I      intronic
chr10:98323927(-) A-I      intronic
chr10:98344403(-) A-I      intronic
chr10:98322961(-) A-I      intronic
chr10:98330751(-) A-I      intronic
chr10:98340204(-) A-I      intronic
chr10:98338715(-) A-I      intronic
chr10:98323981(-) A-I      intronic
chr10:98296651(-) A-I      intronic
chr10:98300777(-) A-I      intronic
chr10:98340290(-) A-I      intronic
chr10:98340194(-) A-I      intronic
chr10:98338751(-) A-I      intronic
chr10:98340228(-) A-I      intronic
chr10:98340226(-) A-I      intronic
chr10:98323997(-) A-I      intronic
chr10:98338788(-) A-I      intronic
chr10:98338661(-) A-I      intronic
chr10:98297494(-) A-I      intronic
chr10:98340161(-) A-I      intronic
chr10:98328826(-) A-I      intronic
chr10:98329689(-) A-I      intronic
chr10:98338676(-) A-I      intronic
chr10:98330635(-) A-I      intronic
chr10:98338777(-) A-I      intronic
chr10:98338722(-) A-I      intronic
chr10:98329626(-) A-I      intronic
chr10:98340056(-) A-I      intronic
chr10:98297506(-) A-I      intronic
chr10:98338667(-) A-I      intronic
chr10:98297473(-) A-I      intronic
chr10:98329546(-) A-I      intronic
chr10:98332390(-) A-I      intronic
chr10:98323937(-) A-I      intronic
chr10:98338653(-) A-I      intronic
chr10:98323271(-) A-I      intronic
chr10:98340187(-) A-I      intronic
chr10:98322971(-) A-I      intronic
chr10:98299011(-) A-I      intronic
chr10:98298985(-) A-I      intronic
chr10:98328845(-) A-I      intronic
chr10:98342664(-) A-I      intronic
chr10:98340287(-) A-I      intronic
chr10:98344409(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TM9SF3
chr10:98320668(-) A-I intron -    22327324
chr10:98296691(-) A-I intron -    21960545
chr10:98296716(-) A-I intron -    21960545
chr10:98322971(-) A-I intron -    21960545
chr10:98323937(-) A-I intron -    21960545
chr10:98323997(-) A-I intron -    21960545
chr10:98338621(-) A-I intron -    21960545
chr10:98338712(-) A-I intron -    21960545
chr10:98338722(-) A-I intron -    21960545
chr10:98338777(-) A-I intron -    21960545
chr10:98322971(-) A-G intron -    22484847
chr10:98340161(-) A-G intron -    22484847
chr10:98343775(-) C-T intron -    22484847
chr10:98281484(-) T-C exon 3'UTR    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TM9SF3
chr10:98278050-98278051(-) m6A 3'UTR       24981863//22608085
chr10:98278075-98278076(-) m6A 3'UTR       24981863//22608085
chr10:98278106-98278107(-) m6A 3'UTR       24981863//22608085
chr10:98278149-98278150(-) m6A 3'UTR       22608085
chr10:98278157-98278158(-) m6A 3'UTR       22608085
chr10:98280601-98280602(-) m6A 3'UTR       -
chr10:98280623-98280624(-) m6A 3'UTR       -
chr10:98280646-98280647(-) m6A 3'UTR       -
chr10:98281033-98281034(-) Cm 3'UTR       -
chr10:98281112-98281113(-) m6A 3'UTR       26404942
chr10:98281319-98281320(-) m6A 3'UTR       26404942
chr10:98281367-98281368(-) m6A 3'UTR       26404942
chr10:98281394-98281395(-) m6A 3'UTR       26404942
chr10:98281529-98281530(-) m6A 3'UTR       26404942
chr10:98281659-98281660(-) m6A 3'UTR       26404942
chr10:98281708-98281709(-) m6A 3'UTR       24284625//26404942
chr10:98281731-98281732(-) m6A 3'UTR       24284625//22608085
chr10:98281755-98281756(-) m6A 3'UTR       24284625//22608085
chr10:98281951-98281952(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr10:98281966-98281967(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr10:98281999-98282000(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr10:98282006-98282007(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr10:98282016-98282017(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr10:98282066-98282067(-) m6A CDS//exon       24284625//24981863//26404942//27371828//22608085
chr10:98321836-98321837(-) m6A CDS//exon       26404942
chr10:98321847-98321848(-) m6A CDS//exon       26404942
chr10:98336381-98336382(-) m6A exon//intron       26404942
chr10:98336453-98336454(-) m6A CDS//exon       26404942//27773535
chr10:98336519-98336520(-) m6A CDS//exon       24209618//26404942//27773535
chr10:98337276-98337277(-) m6A exon//intron       24209618
chr10:98346496-98346497(-) m6A CDS//exon//intron       24209618//27371828//27773536
chr10:98346516-98346517(-) m6A CDS//intron       24209618//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-197-3p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pooled sera     27278097
Exosome Primary ovarian tumor cells|Serum     18589210
Exosome Peripheral blood mononuclear cells     19002258
Exosome B cell line (Raji)|Jurkat-derived T cell line (J77cl20)     21505438
Exosome Ovarian follicular fluid     22116803
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome B lymphoblastoid cells|Endothelial cells     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Myotube     27396686
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Neural progenitor cells     21363885
TM9SF3
Chromatin K562 cells     -
Cytosol K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-197-3p
Kahalalide F 9898671 Drug resistant
Midostaurin 9829523 Drug resistant
8-Aminoadenosine 96851 Drug resistant
2,5-Dimethyl-1,4-benzoquinone 8718 Drug sensitive
1,9-Pyrazoloanthrone 8515 Drug resistant
Kikubasaponin 6712587 Drug resistant
(2E)-2-Benzoyl-3-(2-phenyl-1H-indol-3-yl)acrylonitrile 5986877 Drug resistant
Caracemide 54747 Drug sensitive
Herveline O 5459269 Drug sensitive
Indanthren Corinth RK 5351878 Drug sensitive
Alvocidib 5287969 Drug resistant
Plumericin 5281545 Drug sensitive
Spiperone 5265 Drug resistant
Pyrimethamine 4993 Drug resistant
Di-n-octyl-secalonsaure A 430141 Drug sensitive
4-Quinazolinamine, 2-[2-(1-pyrrolidinylazo)phenyl]- 424332 Drug resistant
Antineoplastic-645804 371505 Drug sensitive
Girolline 362388 Drug resistant
1-Chloro-3-(3-chloropropylsulfonylsulfanyl)propane 355643 Drug sensitive
Maxima isoflavone D 343081 Drug sensitive
Bis(helenalinyl)glutarate 336831 Drug sensitive
Zonarol 332671 Drug sensitive
Pinafide 327045 Drug resistant
Rustaiyan A 324967 Drug sensitive
Cyclo-C 279062 Drug resistant
1H-Benzo[a]carbazole-1,4(11H)-dione, 11-methyl- 261066 Drug sensitive
Carmofur 2577 Drug resistant
Prumycin HCl 24197905 Drug resistant
CID 24197685 24197685 Drug sensitive
Amsacrine 2179 Drug resistant
Methyl 1,6,8,14a-tetrahydroxy-11-[(4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl)amino]-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-5,6-dihydrobenzo[a]tetracene-2-carboxylate 197261 Drug sensitive
4H-1,3,2-Benzodioxastannin-4-one, 7-amino-2,2-diphenyl- 16683127 Drug sensitive
Morsodren 16682942 Drug sensitive
(6R)-1,6,11-Trihydroxy-8-[(2S,4R,5R,6R)-4-hydroxy-5-[(2S,4R,5R,6R)-5-hydroxy-4-[(2S,5S,6S)-5-[(2S,4R,5R,6R)-4-hydroxy-5-[(2S,4R,5R,6R)-5-hydroxy-4-[(2S,5S,6S)-5-hydroxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-3-methyl-5,6-dihydrobenzo[a]anthracene-7,12-dione 15507920 Drug sensitive
Edelfosine 1392 Drug resistant
(S)-2-Amino-3-(hydroxy(nitroso)amino)propanoic acid 136096147 Drug resistant
Porfiromycin 13116 Drug resistant
(2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive
2-Chloro-3-(phenylsulfonyl)propanenitrile 121458 Drug sensitive
Melampodinin 11953936 Drug sensitive
Cyanoaminopyranopyridine derivatives 11494577 Drug resistant
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive
4-methoxy-2,6-bis[hydroxy(methyl)amino]-1,3,5-triazine - Drug resistant
anthraquinone, 1-hydroxy-4-[p-(2-hydroxyethyl)anilino]- - Drug resistant
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
Camptothecin Derivative - Drug resistant
michicarcin - Drug resistant
tunicamycin - Drug resistant
1h-benzo[a]carbazole-1,4(11h)-dione, 11-phenyl- - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
inosine, 6-thio-, 2',3',5'-tris(4-methoxybenzoate) - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
dolavaline - Drug sensitive
geldanamycin analog - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-197-3p
Curcumin 969516 Drug interaction    RC00001493
Cianidanol 9064 Drug interaction    RC00001483
Alocrest 60780 Drug interaction    RC00001489
Gemcitabine 60750 Drug interaction    RC00001488
Cholesterol 5997 Drug interaction    RC00001482
Vincristine 5978 Drug interaction    RC00001481
Ascorbic acid 54670067 Drug interaction    RC00001496
Vorinostat 5311 Drug interaction    RC00001480
Eloxatine 5310940 Drug interaction    RC00001495
Naringin 442428 Drug interaction    RC00001492
Etoposide 36462 Drug interaction    RC00001487
Paclitaxel 36314 Drug interaction    RC00001486
5-Fluorouracil 3385 Drug interaction    RC00001479
Doxorubicin 31703 Drug interaction    RC00001485
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001478
Tamoxifen 2733526 Drug interaction    RC00001494
Erlotinib 176870 Drug interaction    RC00001491
Docetaxel 148124 Drug interaction    RC00001490
Hesperidin 10621 Drug interaction    RC00001484
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001497
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-197-3p
Cisplatin 5702198       30841025
Paclitaxel 36314       30841025
Doxorubicin 31703       30841025
Gefitinib 123631       30841025

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-197-3p
Interactor2: TM9SF3

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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