Basic Information:

  VIRBase ID:  

HHID00047375

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-107:  MIMAT0000104          NHLRC2:  NM_198514     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-107	NHLRC2
miRBase Accession/Entrez ID	MIMAT0000104	374354
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	FINCA

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-107	rs1169479440 chr10:89592763    C/T rs1367154851 chr10:89592757    G/A rs1424344741 chr10:89592761    G/A rs748277679 chr10:89592768    A/G rs769058331 chr10:89592764    C/T rs776766492 chr10:89592767    T/A rs901180005 chr10:89592777    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NHLRC2	chr10:115675649(+) A-I      3'UTR chr10:115675599(+) A-I      3'UTR chr10:115675642(+) A-I      3'UTR chr10:115627361(+) A-I      intronic chr10:115675657(+) A-I      3'UTR chr10:115675663(+) A-I      3'UTR chr10:115675665(+) A-I      3'UTR chr10:115624907(+) A-I      intronic chr10:115624765(+) A-I      intronic chr10:115624225(+) A-I      intronic chr10:115624336(+) A-I      intronic chr10:115624248(+) A-I      intronic chr10:115624915(+) A-I      intronic chr10:115624301(+) A-I      intronic chr10:115624270(+) A-I      intronic chr10:115624838(+) A-I      intronic chr10:115624850(+) A-I      intronic chr10:115648807(+) A-I      intronic chr10:115624809(+) A-I      intronic chr10:115624303(+) A-I      intronic chr10:115624397(+) A-I      intronic chr10:115624388(+) A-I      intronic chr10:115624821(+) A-I      intronic chr10:115647731(+) A-I      intronic chr10:115621736(+) A-I      intronic chr10:115624281(+) A-I      intronic chr10:115624295(+) A-I      intronic chr10:115624363(+) A-I      intronic chr10:115621735(+) A-I      intronic chr10:115624848(+) A-I      intronic chr10:115624732(+) A-I      intronic chr10:115624201(+) A-I      intronic chr10:115624335(+) A-I      intronic chr10:115622644(+) A-I      intronic chr10:115624271(+) A-I      intronic chr10:115666584(+) A-I      intronic chr10:115647807(+) A-I      intronic chr10:115666560(+) A-I      intronic chr10:115675443(+) A-I      3'UTR chr10:115628720(+) A-I      intronic chr10:115631057(+) A-I      intronic chr10:115628722(+) A-I      intronic chr10:115628689(+) A-I      intronic chr10:115675666(+) A-I      3'UTR chr10:115670145(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NHLRC2	chr10:115628689(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NHLRC2	chr10:115614440-115614441(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr10:115614455-115614456(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr10:115614470-115614471(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr10:115614549-115614550(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr10:115614557-115614558(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr10:115614586-115614587(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//22608085 chr10:115614629-115614630(+) m6A 5'UTR//exon       24209618//25456834//22608085 chr10:115614685-115614686(+) m6A CDS//exon       24209618 chr10:115614734-115614735(+) m6A CDS//exon       - chr10:115614782-115614783(+) m6A CDS//exon       24284625 chr10:115618301-115618302(+) m6A CDS//exon       24284625 chr10:115618311-115618312(+) m6A CDS//exon       24284625 chr10:115618468-115618469(+) m6A exon//intron       24981863 chr10:115636415-115636416(+) m6A CDS       24284625//24981863//22575960//22608085 chr10:115636454-115636455(+) m6A CDS       24284625//24981863//22575960//22608085 chr10:115636465-115636466(+) m6A CDS       24284625//24981863//22575960//22608085 chr10:115636493-115636494(+) m6A CDS       24284625//24981863//22575960//22608085 chr10:115636546-115636547(+) m6A CDS       24284625//24209618//24981863//22608085 chr10:115636583-115636584(+) m6A CDS       24284625//24981863//22608085 chr10:115636642-115636643(+) m6A CDS       24284625//24981863//22608085 chr10:115636672-115636673(+) m6A CDS       24284625//24981863//22608085 chr10:115636679-115636680(+) m6A CDS       24284625//24981863//22608085 chr10:115636712-115636713(+) m6A CDS       24981863//22608085 chr10:115644132-115644133(+) m6A CDS       24981863 chr10:115664631-115664632(+) m6A CDS       24284625//24981863 chr10:115664638-115664639(+) m6A CDS       24284625//24981863 chr10:115664649-115664650(+) m6A CDS       24284625//24981863//22608085 chr10:115664707-115664708(+) m6A CDS       24284625//24209618//24981863//22608085 chr10:115664721-115664722(+) m6A CDS       24284625//24209618//24981863//22608085 chr10:115664732-115664733(+) m6A CDS       24284625//24209618//24981863//22608085 chr10:115668060-115668061(+) m6A CDS       24284625//24209618//24981863//22608085 chr10:115668086-115668087(+) m6A CDS       24284625//24209618//24981863//22608085 chr10:115668188-115668189(+) m6A CDS       24284625 chr10:115668373-115668374(+) m6A 3'UTR       24981863 chr10:115668951-115668952(+) m6A 3'UTR       24981863//22608085 chr10:115668972-115668973(+) m6A 3'UTR       24981863//22608085 chr10:115668989-115668990(+) m6A 3'UTR       24981863//22608085 chr10:115669076-115669077(+) m6A 3'UTR       24981863//22608085 chr10:115669084-115669085(+) m6A 3'UTR       24981863//22608085 chr10:115674950-115674951(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-107	Cytoplasm Cell line (HeLa)     21695135 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome K562 cells     24460325 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Hepatoma cells     23771658 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion HEK-293 cells|HeLa cells|Myotube     27396686 Mitochondrion HEK-293 cells|HeLa cells|Skeletal muscle cells     27563705 Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Colon adenocarcinoma cells     20864815
	NHLRC2	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-107	CID 9604911 9604911 Drug resistant Morpholine-N-dithiocarbamate 72675 Drug sensitive Neocuproine 65237 Drug sensitive Mevastatin 64715 Drug resistant Aspiculamycin hcl 54600418 Drug resistant Simvastatin 54454 Drug resistant Lovastatin 53232 Drug resistant Dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498558 Drug sensitive Rogiolol 402519 Drug sensitive Sparfosic acid 39981 Drug resistant Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive Leflunomide 3899 Drug resistant 4-Phenacyloxychromen-2-one 386272 Drug resistant (3R,5S)-Fluvastatin(1-) 37888681 Drug resistant 2-Hydroxy discorhabdin D 362391 Drug sensitive Thiosangivamycin 3580213 Drug sensitive 5-Cinnamylidene-1,3-thiazolidine-2,4-dione 315044 Drug resistant Stannane, trimethyl[(4-morpholinylthioxomethyl)thio]- 300936 Drug sensitive Salarin C 24867082 Drug resistant 8-Hydroxyquinoline 1923 Drug sensitive Antineoplastic-633273 15954131 Drug sensitive Methyl 3,4-dichloro-5-nitro-2-furoate 147711 Drug sensitive Formycin b 135449281 Drug sensitive Inosine dialdehyde 135400916 Drug sensitive [(8Ar)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2-methylbutanoate 134694047 Drug resistant 43-Dioxypectenotoxin 131751434 Drug resistant Cladospirone bisepoxide 10316810 Drug sensitive 9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 5-methoxy- - Drug resistant antineoplastic-d665838 - Drug resistant protein: pa30-14 - Drug resistant 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive geldanamycin, n,n'-dimethyl - Drug sensitive antineoplastic-625543 - Drug sensitive antineoplastic-641296 - Drug sensitive antineoplastic-641297 - Drug sensitive antineoplastic-654379 - Drug sensitive tetra(isobutenyl)antimony bromide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-107	Formaldehyde 712 Drug interaction    RC00001194 Oxaliplatine 6857599 Drug interaction    RC00001211 Cytarabine 6253 Drug interaction    RC00001199 Estradiol 5757 Drug interaction    RC00001198 Eloxatine 5310940 Drug interaction    RC00001210 Imatinib 5291 Drug interaction    RC00001197 Morphine 5288826 Drug interaction    RC00001209 Decitabine 451668 Drug interaction    RC00001207 Tretinoin 444795 Drug interaction    RC00001206 Trichostatin A 444732 Drug interaction    RC00001205 Etoposide 36462 Drug interaction    RC00001203 Paclitaxel 36314 Drug interaction    RC00001202 5-Fluorouracil 3385 Drug interaction    RC00001196 Doxorubicin 31703 Drug interaction    RC00001201 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001195 Tamoxifen 2733526 Drug interaction    RC00001208 Camptothecin 24360 Drug interaction    RC00001200 Olaparib 23725625 Drug interaction    RC00001212 Leucovorin 135403648 Drug interaction    RC00001213 Ginsenoside Rh2 119307 Drug interaction    RC00001204 Marine fungal metabolite 1386A - Drug interaction    RC00001216 Chemotherapy - Drug interaction    RC00008828 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001214 Anthranilamide-pyrazolo[1,5-a]pyrimidine - Drug interaction    RC00001215

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-107
Interactor2: NHLRC2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.