Detail Information

Basic Information:


  VIRBase ID:  

HHID00046787

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-103a-3p:           MFSD5:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-103a-3p MFSD5
miRBase
Accession/Entrez ID		 MIMAT0000101 84975
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - hsMOT2//SLC61A1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-103a-3p
rs572980521 chr5:168560917    C/G
rs748411363 chr5:168560918    A/G
rs748411363 chr5:168560918    A/T
rs769854452 chr5:168560926    T/C
rs1222085747 chr20:3917554    A/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MFSD5
chr12:53645114-53645115(+) m6A exon       24981863
chr12:53645496-53645497(+) m6A 5'UTR//exon       22608085
chr12:53645547-53645548(+) m6A CDS//exon       -
chr12:53645556-53645557(+) m6A CDS//exon       -
chr12:53645960-53645961(+) m6A 5'UTR//intron       24284625//25456834//24981863
chr12:53646039-53646040(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863
chr12:53646678-53646679(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr12:53646699-53646700(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr12:53646749-53646750(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr12:53646813-53646814(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr12:53646984-53646985(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr12:53646995-53646996(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22608085
chr12:53647151-53647152(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr12:53647280-53647281(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr12:53647292-53647293(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr12:53647321-53647322(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr12:53647355-53647356(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr12:53647429-53647430(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr12:53647442-53647443(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr12:53647732-53647733(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22608085
chr12:53647825-53647826(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr12:53647893-53647894(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr12:53647984-53647985(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr12:53647998-53647999(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr12:53648101-53648102(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr12:53648119-53648120(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr12:53648173-53648174(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-103a-3p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Neural progenitor cells     21363885
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Human cervical cancer cell line (HeLa)     25760330
Exosome Pooled sera     27278097
Exosome Serum     18589210
Exosome Peripheral blood mononuclear cells     19002258
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Human mast cell line (HMC-1)     24009880
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Microvesicle Plasma     19002258
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Myotube|Osteosarcoma cell line (143B)     27396686
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Colon adenocarcinoma cells     20864815
MFSD5
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-103a-3p
Morpholine-N-dithiocarbamate 72675 Drug sensitive
Mevastatin 64715 Drug resistant
Irinotecan 60838 Drug resistant
Aspiculamycin hcl 54600418 Drug resistant
Simvastatin 54454 Drug resistant
Reumycin 5351216 Drug resistant
Lovastatin 53232 Drug resistant
Pyrimethamine 4993 Drug resistant
Chelocardin dodecyl sulfate 415844 Drug resistant
Rogiolol 402519 Drug sensitive
Thiosangivamycin 3580213 Drug sensitive
5-Cinnamylidene-1,3-thiazolidine-2,4-dione 315044 Drug resistant
Salarin C 24867082 Drug resistant
Antineoplastic-633273 15954131 Drug sensitive
Inosine dialdehyde 135400916 Drug sensitive
[(8Ar)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2-methylbutanoate 134694047 Drug resistant
Pepleo 122804 Drug resistant
Cladospirone bisepoxide 10316810 Drug sensitive
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 5-methoxy- - Drug resistant
protein: pa30-14 - Drug resistant
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
antineoplastic-625543 - Drug sensitive
antineoplastic-641297 - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-103a-3p
Curcumin 969516 Drug interaction    RC00001161
Formaldehyde 712 Drug interaction    RC00001151
Oxaliplatine 6857599 Drug interaction    RC00001165
Estradiol 5757 Drug interaction    RC00001155
Eloxatine 5310940 Drug interaction    RC00001164
Imatinib 5291 Drug interaction    RC00001154
Morphine 5288826 Drug interaction    RC00001163
Decitabine 451668 Drug interaction    RC00001160
Trichostatin A 444732 Drug interaction    RC00001159
Etoposide 36462 Drug interaction    RC00001158
5-Fluorouracil 3385 Drug interaction    RC00001153
Doxorubicin 31703 Drug interaction    RC00001157
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001152
Tamoxifen 2733526 Drug interaction    RC00001162
Camptothecin 24360 Drug interaction    RC00001156
Olaparib 23725625 Drug interaction    RC00001166
Leucovorin 135403648 Drug interaction    RC00001167
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001168
Marine fungal metabolite 1386A - Drug interaction    RC00001169

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-103a-3p
Interactor2: MFSD5

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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