Basic Information:

  VIRBase ID:  

HHID00046487

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-98-5p:  MIMAT0000096          INTS6L:  NM_001351606     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-98-5p	INTS6L
miRBase Accession/Entrez ID	MIMAT0000096	203522
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DDX26B

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-98-5p	rs1357591935 chrX:53556304    T/C rs1556934729 chrX:53556307    A/G rs1556934737 chrX:53556311    T/G rs1556934741 chrX:53556316    C/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	INTS6L	chrX:134692797(+) A-I      intronic chrX:134694530(+) A-I      intronic chrX:134694534(+) A-I      intronic chrX:134694589(+) A-I      intronic chrX:134694512(+) A-I      intronic chrX:134694619(+) A-I      intronic chrX:134694942(+) A-I      intronic chrX:134694978(+) A-I      intronic chrX:134694988(+) A-I      intronic chrX:134695075(+) A-I      intronic chrX:134695093(+) A-I      intronic chrX:134698396(+) A-I      intronic chrX:134694513(+) A-I      intronic chrX:134698514(+) A-I      intronic chrX:134702575(+) A-I      intronic chrX:134694615(+) A-I      intronic chrX:134674857(+) A-I      intronic chrX:134698423(+) A-I      intronic chrX:134674839(+) A-I      intronic chrX:134674721(+) A-I      intronic chrX:134676280(+) A-I      intronic chrX:134698578(+) A-I      intronic chrX:134676151(+) A-I      intronic chrX:134689799(+) A-I      intronic chrX:134702693(+) A-I      intronic chrX:134692891(+) A-I      intronic chrX:134694772(+) A-I      intronic chrX:134666855(+) A-I      intronic chrX:134698443(+) A-I      intronic chrX:134688956(+) A-I      intronic chrX:134694758(+) A-I      intronic chrX:134710105(+) A-I      intronic chrX:134695043(+) A-I      intronic chrX:134657175(+) A-I      intronic chrX:134702514(+) A-I      intronic chrX:134657046(+) A-I      intronic chrX:134695088(+) A-I      intronic chrX:134676181(+) A-I      intronic chrX:134692910(+) A-I      intronic chrX:134694947(+) A-I      intronic chrX:134698510(+) A-I      intronic chrX:134676167(+) A-I      intronic chrX:134694613(+) A-I      intronic chrX:134710173(+) A-I      intronic chrX:134674942(+) A-I      intronic chrX:134695112(+) A-I      intronic chrX:134694638(+) A-I      intronic chrX:134698577(+) A-I      intronic chrX:134692930(+) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-98-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Human cervical cancer cell line (HeLa)     25760330 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome B lymphoblastoid cells|Endothelial cells|Epithelial cells|Mast cells|Tongue tissue     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)     25330373 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	INTS6L	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-98-5p	Thapsia villosa compd 5477211 Drug sensitive Rogiolol 402519 Drug sensitive N-Hydroxy-N-methylpropanethioamide 371713 Drug sensitive 2-(naphthalen-2-yl)-1-(3,4,5-trimethoxyphenyl)-1h-imidazole - Drug sensitive aquatris(1,3-diphenylpropane-1,3-dionato)neodymium(iii) - Drug sensitive ellipticine, 6-(3-aminopropyl)-, dihydrochloride - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-98-5p	10-Hydroxycamptothecin 97226 Drug interaction    RC00001036 Curcumin 969516 Drug interaction    RC00001040 Formaldehyde 712 Drug interaction    RC00001027 Gemcitabine 60750 Drug interaction    RC00001034 Estradiol 5757 Drug interaction    RC00001031 Calcitriol 5280453 Drug interaction    RC00001041 5-Fluorouracil 3385 Drug interaction    RC00001030 Doxorubicin 31703 Drug interaction    RC00001033 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001029 Celecoxib 2662 Drug interaction    RC00001028 Lenalidomide 216326 Drug interaction    RC00001039 Arsenic trioxide 14888 Drug interaction    RC00001032 Docetaxel 148124 Drug interaction    RC00001038 Ginsenoside Rh2 119307 Drug interaction    RC00001037 Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00001043 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001042 Trastuzumab - Drug interaction    RC00001045 LPS - Drug interaction    RC00001044

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-98-5p	Cisplatin 5702198       27270317

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-98-5p
Interactor2: INTS6L

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.