Basic Information:

  VIRBase ID:  

HHID00046257

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-96-5p:  MIMAT0000095          PDCD4:  NM_145341     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-96-5p	PDCD4
miRBase Accession/Entrez ID	MIMAT0000095	27250
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	H731

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-96-5p	rs1333938704 chr7:129774745    A/G rs1483018024 chr7:129774750    G/A rs772409471 chr7:129774748    G/A rs776335197 chr7:129774752    T/C rs957232317 chr7:129774742    A/T rs587776522 chr7:129774757    C/T rs587776523 chr7:129774756    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PDCD4	chr10:112650922(+) A-I      intronic chr10:112636041(+) A-I      intronic chr10:112639276(+) A-I      intronic chr10:112650998(+) A-I      intronic chr10:112639286(+) A-I      intronic chr10:112635876(+) A-I      intronic chr10:112635992(+) A-I      intronic chr10:112635991(+) A-I      intronic chr10:112635900(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PDCD4	chr10:112639276(+) A-G intron -    22484847 chr10:112639286(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PDCD4	chr10:112631658-112631659(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr10:112631664-112631665(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr10:112631689-112631690(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr10:112631711-112631712(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr10:112631745-112631746(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr10:112635819-112635820(+) m6A 5'UTR//CDS//exon//intron       24209618//24981863 chr10:112641043-112641044(+) m6A CDS//exon       22608085 chr10:112641143-112641144(+) m6A CDS//exon       24981863//22575960//22608085 chr10:112641155-112641156(+) m6A CDS//exon       24981863//22575960//22608085 chr10:112641279-112641280(+) m6A CDS//exon       24981863//22575960//22608085 chr10:112642797-112642798(+) m6A CDS//exon       24981863//27773535//22575960 chr10:112645028-112645029(+) m6A CDS//exon       22575960 chr10:112645067-112645068(+) m6A CDS//exon       22575960 chr10:112657830-112657831(+) m6A CDS//exon       26404942 chr10:112657854-112657855(+) m6A 3'UTR//exon       26404942 chr10:112658366-112658367(+) m6A 3'UTR//exon       27773535 chr10:112658388-112658389(+) m6A 3'UTR//exon       27773535 chr10:112658393-112658394(+) m6A 3'UTR//exon       27773535 chr10:112658417-112658418(+) m6A 3'UTR//exon       27773535 chr10:112658436-112658437(+) m6A 3'UTR//exon       27773535 chr10:112658449-112658450(+) m6A 3'UTR//exon       27773535 chr10:112658482-112658483(+) m6A 3'UTR       27773535 chr10:112658537-112658538(+) m6A 3'UTR       27773535 chr10:112658587-112658588(+) m6A 3'UTR       27773535 chr10:112658621-112658622(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-96-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Peripheral blood mononuclear cells     19002258 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Seminal fluid|Tongue tissue     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	PDCD4	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-96-5p	(10S,13S,16S,19S)-16-Butan-2-yl-10,11,14-trimethyl-3-(oxiran-2-ylmethyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 152771884 Drug resistant

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-96-5p	Gemcitabine 60750 Drug interaction    RC00001021 Clopidogrel 60606 Drug interaction    RC00001020 Cholesterol 5997 Drug interaction    RC00001016 D-Glucose 5793 Drug interaction    RC00001015 Vorinostat 5311 Drug interaction    RC00001014 Imatinib 5291 Drug interaction    RC00001013 Paclitaxel 36314 Drug interaction    RC00001019 5-Fluorouracil 3385 Drug interaction    RC00001012 Enoxacin 3229 Drug interaction    RC00001011 Doxorubicin 31703 Drug interaction    RC00001018 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001010 Tamoxifen 2733526 Drug interaction    RC00001023 Verapamil 2520 Drug interaction    RC00001009 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001025 Olaparib 23725625 Drug interaction    RC00001024 Arsenic trioxide 14888 Drug interaction    RC00001017 Docetaxel 148124 Drug interaction    RC00001022 Chemotherapy - Drug interaction    RC00008826 TRAIL therapy - Drug interaction    RC00001026

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-96-5p	Oxaliplatin 9887053       31089750 Paclitaxel 36314       26323677 5-Fluorouracil 3385       31089750 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124 Platinum 23939       25872328

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-96-5p
Interactor2: PDCD4

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.