Detail Information

Basic Information:


  VIRBase ID:  

HHID00046238

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-96-5p:           CCR7:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-96-5p CCR7
miRBase
Accession/Entrez ID		 MIMAT0000095 1236
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BLR2//CC-CKR-7//CCR-7//CD197//CDw197//CMKBR7//EBI1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-96-5p
rs1333938704 chr7:129774745    A/G
rs1483018024 chr7:129774750    G/A
rs772409471 chr7:129774748    G/A
rs776335197 chr7:129774752    T/C
rs957232317 chr7:129774742    A/T
rs587776522 chr7:129774757    C/T
rs587776523 chr7:129774756    G/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CCR7
chr17:38713987(-) A-I      intronic
chr17:38713981(-) A-I      intronic
chr17:38713982(-) A-I      intronic
chr17:38714005(-) A-I      intronic
chr17:38713986(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CCR7
chr17:38710149-38710150(-) m6A 3'UTR       24981863//28052920//27371828
chr17:38710156-38710157(-) m6A 3'UTR       24981863//28052920//27371828
chr17:38710237-38710238(-) m6A 3'UTR       27371828
chr17:38710482-38710483(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710495-38710496(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710510-38710511(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710537-38710538(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710555-38710556(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710574-38710575(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710590-38710591(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710604-38710605(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710623-38710624(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710706-38710707(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710727-38710728(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710734-38710735(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710755-38710756(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710772-38710773(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710796-38710797(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710913-38710914(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710966-38710967(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710975-38710976(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38711016-38711017(-) m6A CDS       24981863//28052920//27371828
chr17:38711102-38711103(-) m6A CDS       27371828
chr17:38711819-38711820(-) m6A CDS       28052920//26404942
chr17:38711859-38711860(-) m6A CDS       28052920//26404942
chr17:38711966-38711967(-) m6A 5'UTR//CDS       24284625//24981863//28052920//26404942//27371828
chr17:38712011-38712012(-) m6A 5'UTR//CDS       24284625//24981863//28052920//26404942//27371828
chr17:38712026-38712027(-) m6A 5'UTR//CDS       24284625//24981863//28052920//26404942//27371828
chr17:38715189-38715190(-) m6A 5'UTR//CDS//intron       28052920//27371828
chr17:38716998-38716999(-) m6A 5'UTR//intron       27371828
chr17:38717003-38717004(-) m6A 5'UTR//intron       27371828
chr17:38717013-38717014(-) m6A 5'UTR//intron       27371828
chr17:38717070-38717071(-) m6A 5'UTR//intron       -
chr17:38717106-38717107(-) m6A 5'UTR//intron       -
chr17:38717189-38717190(-) m6A 5'UTR//intron       -
chr17:38717195-38717196(-) m6A 5'UTR//intron       -
chr17:38717227-38717228(-) m6A 5'UTR//intron       -
chr17:38721656-38721657(-) m6A 5'UTR//CDS       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-96-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Peripheral blood mononuclear cells     19002258
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Seminal fluid|Tongue tissue     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
CCR7
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-96-5p
(10S,13S,16S,19S)-16-Butan-2-yl-10,11,14-trimethyl-3-(oxiran-2-ylmethyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 152771884 Drug resistant
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-96-5p
Gemcitabine 60750 Drug interaction    RC00001021
Clopidogrel 60606 Drug interaction    RC00001020
Cholesterol 5997 Drug interaction    RC00001016
D-Glucose 5793 Drug interaction    RC00001015
Vorinostat 5311 Drug interaction    RC00001014
Imatinib 5291 Drug interaction    RC00001013
Paclitaxel 36314 Drug interaction    RC00001019
5-Fluorouracil 3385 Drug interaction    RC00001012
Enoxacin 3229 Drug interaction    RC00001011
Doxorubicin 31703 Drug interaction    RC00001018
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001010
Tamoxifen 2733526 Drug interaction    RC00001023
Verapamil 2520 Drug interaction    RC00001009
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001025
Olaparib 23725625 Drug interaction    RC00001024
Arsenic trioxide 14888 Drug interaction    RC00001017
Docetaxel 148124 Drug interaction    RC00001022
Chemotherapy - Drug interaction    RC00008826
TRAIL therapy - Drug interaction    RC00001026
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-96-5p
Oxaliplatin 9887053       31089750
Paclitaxel 36314       26323677
5-Fluorouracil 3385       31089750
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124
Platinum 23939       25872328

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-96-5p
Interactor2: CCR7

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

Starting a new search, please wait ...