Basic Information:

  VIRBase ID:  

HHID00044888

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30a-3p:  MIMAT0000088          MGLL:  NM_001388313     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30a-3p	MGLL
miRBase Accession/Entrez ID	MIMAT0000088	11343
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HU-K5//HUK5//MAGL//MGL

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30a-3p	rs149150037 chr6:71403567    G/A rs149150037 chr6:71403567    G/C rs370184894 chr6:71403566    C/A rs370184894 chr6:71403566    C/T rs552541514 chr6:71403558    C/G rs745605208 chr6:71403563    ATCCG/A rs746505574 chr6:71403557    G/A rs746505574 chr6:71403557    G/T rs746965145 chr6:71403554    GCT/G rs750918072 chr6:71403564    T/C rs765735953 chr6:71403560    A/T rs770865356 chr6:71403559    A/AC rs776574456 chr6:71403560    A/AAGCTGGAGT rs368070339 chr6:71403571    G/A rs769702885 chr6:71403570    TG/T rs775921090 chr6:71403574    AGCC/A rs781617967 chr6:71403573    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MGLL	chr3:127490392(-) A-I      intronic chr3:127512936(-) A-I      intronic chr3:127414298(-) A-I      intronic chr3:127456048(-) A-I      intronic chr3:127414311(-) A-I      intronic chr3:127415395(-) A-I      intronic chr3:127414323(-) A-I      intronic chr3:127414324(-) A-I      intronic chr3:127415394(-) A-I      intronic chr3:127513053(-) A-I      intronic chr3:127415385(-) A-I      intronic chr3:127415325(-) A-I      intronic chr3:127415304(-) A-I      intronic chr3:127513188(-) A-I      intronic chr3:127461755(-) A-I      intronic chr3:127511380(-) A-I      intronic chr3:127511302(-) A-I      intronic chr3:127511296(-) A-I      intronic chr3:127511294(-) A-I      intronic chr3:127511287(-) A-I      intronic chr3:127508459(-) A-I      intronic chr3:127508458(-) A-I      intronic chr3:127498224(-) A-I      intronic chr3:127497983(-) A-I      intronic chr3:127461885(-) A-I      intronic chr3:127497961(-) A-I      intronic chr3:127497841(-) A-I      intronic chr3:127489115(-) A-I      intronic chr3:127489137(-) A-I      intronic chr3:127512632(-) A-I      intronic chr3:127485813(-) A-I      intronic chr3:127489138(-) A-I      intronic chr3:127490268(-) A-I      intronic chr3:127490284(-) A-I      intronic chr3:127490288(-) A-I      intronic chr3:127490472(-) A-I      intronic chr3:127497739(-) A-I      intronic chr3:127485795(-) A-I      intronic chr3:127485696(-) A-I      intronic chr3:127485657(-) A-I      intronic chr3:127497830(-) A-I      intronic chr3:127461939(-) A-I      intronic chr3:127461931(-) A-I      intronic chr3:127525625(-) A-I      intronic chr3:127489047(-) A-I      intronic chr3:127488973(-) A-I      intronic chr3:127461429(-) A-I      intronic chr3:127525648(-) A-I      intronic chr3:127488192(-) A-I      intronic chr3:127488111(-) A-I      intronic chr3:127547404(-) A-I      intronic chr3:127547510(-) A-I      intronic chr3:127461228(-) A-I      intronic chr3:127511489(-) A-I      intronic chr3:127488108(-) A-I      intronic chr3:127488107(-) A-I      intronic chr3:127512516(-) A-I      intronic chr3:127512569(-) A-I      intronic chr3:127457061(-) A-I      intronic chr3:127456899(-) A-I      intronic chr3:127456662(-) A-I      intronic chr3:127456620(-) A-I      intronic chr3:127456584(-) A-I      intronic chr3:127457098(-) A-I      intronic chr3:127457097(-) A-I      intronic chr3:127450118(-) A-I      intronic chr3:127488082(-) A-I      intronic chr3:127446387(-) A-I      intronic chr3:127446372(-) A-I      intronic chr3:127444882(-) A-I      intronic chr3:127415372(-) A-I      intronic chr3:127414492(-) A-I      intronic chr3:127414293(-) A-I      intronic chr3:127512598(-) A-I      intronic chr3:127512623(-) A-I      intronic chr3:127490289(-) A-I      intronic chr3:127512651(-) A-I      intronic chr3:127485827(-) A-I      intronic chr3:127512655(-) A-I      intronic chr3:127512656(-) A-I      intronic chr3:127513067(-) A-I      intronic chr3:127516666(-) A-I      intronic chr3:127520132(-) A-I      intronic chr3:127520215(-) A-I      intronic chr3:127520216(-) A-I      intronic chr3:127520342(-) A-I      intronic chr3:127522087(-) A-I      intronic chr3:127489032(-) A-I      intronic chr3:127522095(-) A-I      intronic chr3:127489092(-) A-I      intronic chr3:127511464(-) A-I      intronic chr3:127511408(-) A-I      intronic chr3:127414465(-) A-I      intronic chr3:127526743(-) A-I      intronic chr3:127461253(-) A-I      intronic chr3:127519962(-) A-I      intronic chr3:127444856(-) A-I      intronic chr3:127498127(-) A-I      intronic chr3:127461170(-) A-I      intronic chr3:127498017(-) A-I      intronic chr3:127497877(-) A-I      intronic chr3:127455811(-) A-I      intronic chr3:127415397(-) A-I      intronic chr3:127497965(-) A-I      intronic chr3:127419840(-) A-I      intronic chr3:127424572(-) A-I      intronic chr3:127461689(-) A-I      intronic chr3:127488002(-) A-I      intronic chr3:127497865(-) A-I      intronic chr3:127513066(-) A-I      intronic chr3:127461241(-) A-I      intronic chr3:127446511(-) A-I      intronic chr3:127415368(-) A-I      intronic chr3:127497702(-) A-I      intronic chr3:127461754(-) A-I      intronic chr3:127497797(-) A-I      intronic chr3:127415377(-) A-I      intronic chr3:127457004(-) A-I      intronic chr3:127497733(-) A-I      intronic chr3:127415353(-) A-I      intronic chr3:127445355(-) A-I      intronic chr3:127444664(-) A-I      intronic chr3:127445428(-) A-I      intronic chr3:127446433(-) A-I      intronic chr3:127485802(-) A-I      intronic chr3:127456625(-) A-I      intronic chr3:127526808(-) A-I      intronic chr3:127497735(-) A-I      intronic chr3:127513179(-) A-I      intronic chr3:127445359(-) A-I      intronic chr3:127545202(-) A-I      intronic chr3:127461346(-) A-I      intronic chr3:127461854(-) A-I      intronic chr3:127445546(-) A-I      intronic chr3:127497992(-) A-I      intronic chr3:127424536(-) A-I      intronic chr3:127513029(-) A-I      intronic chr3:127421702(-) A-I      intronic chr3:127498024(-) A-I      intronic chr3:127521960(-) A-I      intronic chr3:127498184(-) A-I      intronic chr3:127415342(-) A-I      intronic chr3:127497759(-) A-I      intronic chr3:127516669(-) A-I      intronic chr3:127526875(-) A-I      intronic chr3:127461876(-) A-I      intronic chr3:127424581(-) A-I      intronic chr3:127445545(-) A-I      intronic chr3:127461853(-) A-I      intronic chr3:127512584(-) A-I      intronic chr3:127445436(-) A-I      intronic chr3:127414478(-) A-I      intronic chr3:127498207(-) A-I      intronic chr3:127513122(-) A-I      intronic chr3:127461350(-) A-I      intronic chr3:127456963(-) A-I      intronic chr3:127415532(-) A-I      intronic chr3:127498110(-) A-I      intronic chr3:127444724(-) A-I      intronic chr3:127424423(-) A-I      intronic chr3:127419801(-) A-I      intronic chr3:127497871(-) A-I      intronic chr3:127419975(-) A-I      intronic chr3:127414504(-) A-I      intronic chr3:127498147(-) A-I      intronic chr3:127526876(-) A-I      intronic chr3:127415530(-) A-I      intronic chr3:127421676(-) A-I      intronic chr3:127456626(-) A-I      intronic chr3:127424507(-) A-I      intronic chr3:127490478(-) A-I      intronic chr3:127456705(-) A-I      intronic chr3:127490377(-) A-I      intronic chr3:127457044(-) A-I      intronic chr3:127415543(-) A-I      intronic chr3:127414530(-) A-I      intronic chr3:127490426(-) A-I      intronic chr3:127461877(-) A-I      intronic chr3:127461795(-) A-I      intronic chr3:127446292(-) A-I      intronic chr3:127519957(-) A-I      intronic chr3:127489027(-) A-I      intronic chr3:127490340(-) A-I      intronic chr3:127512987(-) A-I      intronic chr3:127488038(-) A-I      intronic chr3:127512533(-) A-I      intronic chr3:127525704(-) A-I      intronic chr3:127513166(-) A-I      intronic chr3:127525626(-) A-I      intronic chr3:127512935(-) A-I      intronic chr3:127522069(-) A-I      intronic chr3:127477939(-) A-I      intronic chr3:127446498(-) A-I      intronic chr3:127461381(-) A-I      intronic chr3:127461174(-) A-I      intronic chr3:127498086(-) A-I      intronic chr3:127461176(-) A-I      intronic chr3:127490480(-) A-I      intronic chr3:127488028(-) A-I      intronic chr3:127525682(-) A-I      intronic chr3:127497952(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MGLL	chr3:127415368(-) A-I intron -    22327324 chr3:127415377(-) A-I intron -    22327324 chr3:127456081(-) A-G intron -    22484847 chr3:127456285(-) A-G intron -    22484847 chr3:127456318(-) A-G intron -    22484847 chr3:127414465(-) A-G intron -    22484847 chr3:127415368(-) A-G intron -    22484847 chr3:127415377(-) A-G intron -    22484847 chr3:127415543(-) A-G intron -    22484847 chr3:127419840(-) A-G intron -    22484847 chr3:127419975(-) A-G intron -    22484847 chr3:127420058(-) G-T intron -    22484847 chr3:127421675(-) A-G intron -    22484847 chr3:127421676(-) A-G intron -    22484847 chr3:127421717(-) A-G intron -    22484847 chr3:127424385(-) A-G intron -    22484847 chr3:127424619(-) G-T intron -    22484847 chr3:127444808(-) A-G intron -    22484847 chr3:127444816(-) A-G intron -    22484847 chr3:127444856(-) A-G intron -    22484847 chr3:127445428(-) A-G intron -    22484847 chr3:127445436(-) A-G intron -    22484847 chr3:127445545(-) A-G intron -    22484847 chr3:127445546(-) A-G intron -    22484847 chr3:127446454(-) A-G intron -    22484847 chr3:127455811(-) A-G intron -    22484847 chr3:127456625(-) A-G intron -    22484847 chr3:127456626(-) A-G intron -    22484847 chr3:127456705(-) A-G intron -    22484847 chr3:127457004(-) A-G intron -    22484847 chr3:127457022(-) A-G intron -    22484847 chr3:127457032(-) A-G intron -    22484847 chr3:127457044(-) A-G intron -    22484847 chr3:127457130(-) A-G intron -    22484847 chr3:127461241(-) A-G intron -    22484847 chr3:127461253(-) A-G intron -    22484847 chr3:127461267(-) A-G intron -    22484847 chr3:127461311(-) A-G intron -    22484847 chr3:127461350(-) A-G intron -    22484847 chr3:127461351(-) A-G intron -    22484847 chr3:127461381(-) A-G intron -    22484847 chr3:127461432(-) G-T intron -    22484847 chr3:127461754(-) A-G intron -    22484847 chr3:127461853(-) A-G intron -    22484847 chr3:127461854(-) A-G intron -    22484847 chr3:127461876(-) A-G intron -    22484847 chr3:127461877(-) A-G intron -    22484847 chr3:127485838(-) A-G intron -    22484847 chr3:127485924(-) T-G intron -    22484847 chr3:127485925(-) G-T intron -    22484847 chr3:127488028(-) A-G intron -    22484847 chr3:127488038(-) A-G intron -    22484847 chr3:127488118(-) A-G intron -    22484847 chr3:127489027(-) A-G intron -    22484847 chr3:127489030(-) A-G intron -    22484847 chr3:127489132(-) A-G intron -    22484847 chr3:127490340(-) A-G intron -    22484847 chr3:127490478(-) A-G intron -    22484847 chr3:127497638(-) A-G intron -    22484847 chr3:127497655(-) A-G intron -    22484847 chr3:127497668(-) A-G intron -    22484847 chr3:127497697(-) A-G intron -    22484847 chr3:127497702(-) A-G intron -    22484847 chr3:127497733(-) A-G intron -    22484847 chr3:127497735(-) A-G intron -    22484847 chr3:127497759(-) A-G intron -    22484847 chr3:127497797(-) A-G intron -    22484847 chr3:127497865(-) A-G intron -    22484847 chr3:127497871(-) A-G intron -    22484847 chr3:127497952(-) A-G intron -    22484847 chr3:127497965(-) A-G intron -    22484847 chr3:127497992(-) A-G intron -    22484847 chr3:127498017(-) A-G intron -    22484847 chr3:127498024(-) A-G intron -    22484847 chr3:127498086(-) A-G intron -    22484847 chr3:127498110(-) A-G intron -    22484847 chr3:127498127(-) A-G intron -    22484847 chr3:127498147(-) A-G intron -    22484847 chr3:127498148(-) A-G intron -    22484847 chr3:127498153(-) A-G intron -    22484847 chr3:127498184(-) A-G intron -    22484847 chr3:127498207(-) A-G intron -    22484847 chr3:127512582(-) A-G intron -    22484847 chr3:127512584(-) A-G intron -    22484847 chr3:127512985(-) A-G intron -    22484847 chr3:127512987(-) A-G intron -    22484847 chr3:127513166(-) A-G intron -    22484847 chr3:127513179(-) A-G intron -    22484847 chr3:127516669(-) A-G intron -    22484847 chr3:127519957(-) A-G intron -    22484847 chr3:127519962(-) A-G intron -    22484847 chr3:127519965(-) A-G intron -    22484847 chr3:127522069(-) A-G intron -    22484847 chr3:127525613(-) A-G intron -    22484847 chr3:127525682(-) A-G intron -    22484847 chr3:127525704(-) A-G intron -    22484847 chr3:127526743(-) A-G intron -    22484847 chr3:127526875(-) A-G intron -    22484847 chr3:127528407(-) A-C intron -    22484847 chr3:127449113(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MGLL	chr3:127408154-127408155(-) m6A 3'UTR       28052920 chr3:127408416-127408417(-) m6A 3'UTR       27773535 chr3:127408495-127408496(-) m6A 3'UTR       27773535 chr3:127408813-127408814(-) m6A 3'UTR       24981863//27773535 chr3:127408858-127408859(-) m6A 3'UTR       27773535 chr3:127409027-127409028(-) m6A 3'UTR       27773535 chr3:127409044-127409045(-) m6A 3'UTR       27773535 chr3:127409384-127409385(-) m6A 3'UTR       27773535 chr3:127410129-127410130(-) m6A 3'UTR       24981863 chr3:127410134-127410135(-) m6A 3'UTR       24981863 chr3:127410206-127410207(-) m6A 3'UTR       24981863//27773535 chr3:127410391-127410392(-) m6A 3'UTR       24981863 chr3:127410403-127410404(-) m6A 3'UTR       24981863 chr3:127410451-127410452(-) m6A 3'UTR       24981863 chr3:127410543-127410544(-) m6A 3'UTR       24981863//27773535 chr3:127410688-127410689(-) m6A 3'UTR       24981863//27773535 chr3:127410695-127410696(-) m6A 3'UTR       24981863//27773535 chr3:127411057-127411058(-) m6A CDS//exon       24981863 chr3:127411072-127411073(-) m6A CDS//exon       24981863 chr3:127411092-127411093(-) m6A CDS//exon       24981863 chr3:127414013-127414014(-) m6A CDS//exon//intron       27773535 chr3:127429423-127429424(-) m6A CDS//exon//intron       27773535 chr3:127429470-127429471(-) m6A CDS//exon//intron       27773535 chr3:127441312-127441313(-) m6A CDS//exon       27773535 chr3:127441398-127441399(-) m6A CDS//exon       27773535//27371828 chr3:127454562-127454563(-) m6A CDS//intron       27773535//27371828 chr3:127454614-127454615(-) m6A CDS//intron       27773535//27371828 chr3:127454729-127454730(-) m6A 5'UTR//intron       - chr3:127454759-127454760(-) m6A 5'UTR//intron       - chr3:127454824-127454825(-) m6A 5'UTR//intron       - chr3:127454849-127454850(-) m6A 5'UTR//intron       - chr3:127454906-127454907(-) m6A 5'UTR//intron       - chr3:127454927-127454928(-) m6A 5'UTR//intron       - chr3:127454944-127454945(-) m6A 5'UTR//intron       - chr3:127454952-127454953(-) m6A 5'UTR//intron       - chr3:127540553-127540554(-) m6A CDS//exon       27773535 chr3:127540580-127540581(-) m6A CDS//exon       27773535 chr3:127540608-127540609(-) m6A CDS//exon       27773535 chr3:127540633-127540634(-) m6A CDS//exon       27773535 chr3:127540671-127540672(-) m6A 5'UTR//CDS//exon       27773535 chr3:127540868-127540869(-) m6A 5'UTR//intron       - chr3:127540913-127540914(-) m6A 5'UTR//intron       - chr3:127540935-127540936(-) m6A 5'UTR//intron       - chr3:127541413-127541414(-) m6A 5'UTR//intron       24981863 chr3:127541665-127541666(-) m6A 5'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30a-3p	Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Endothelial cells|Epithelial cells|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Serum     24797360 Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	MGLL	Exosome Blood     - Nucleus HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30a-3p	Sorafenib 216239 Drug interaction    RC00000903

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30a-3p	Imatinib 5291       25349971

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30a-3p
Interactor2: MGLL

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.