Basic Information:

  VIRBase ID:  

HHID00044886

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30a-3p:  MIMAT0000088          ZNF254:  NM_001278663     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30a-3p	ZNF254
miRBase Accession/Entrez ID	MIMAT0000088	9534
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BMZF-5//HD-ZNF1//ZNF539//ZNF91L

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30a-3p	rs149150037 chr6:71403567    G/A rs149150037 chr6:71403567    G/C rs370184894 chr6:71403566    C/A rs370184894 chr6:71403566    C/T rs552541514 chr6:71403558    C/G rs745605208 chr6:71403563    ATCCG/A rs746505574 chr6:71403557    G/A rs746505574 chr6:71403557    G/T rs746965145 chr6:71403554    GCT/G rs750918072 chr6:71403564    T/C rs765735953 chr6:71403560    A/T rs770865356 chr6:71403559    A/AC rs776574456 chr6:71403560    A/AAGCTGGAGT rs368070339 chr6:71403571    G/A rs769702885 chr6:71403570    TG/T rs775921090 chr6:71403574    AGCC/A rs781617967 chr6:71403573    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZNF254	chr19:24301753(+) A-I      intronic chr19:24272902(+) A-I      intronic chr19:24300985(+) A-I      intronic chr19:24272911(+) A-I      intronic chr19:24298036(+) A-I      intronic chr19:24301762(+) A-I      intronic chr19:24301766(+) A-I      intronic chr19:24298059(+) A-I      intronic chr19:24301825(+) A-I      intronic chr19:24298061(+) A-I      intronic chr19:24298070(+) A-I      intronic chr19:24301751(+) A-I      intronic chr19:24301754(+) A-I      intronic chr19:24272885(+) A-I      intronic chr19:24272896(+) A-I      intronic chr19:24273513(+) A-I      intronic chr19:24301735(+) A-I      intronic chr19:24292793(+) A-I      intronic chr19:24273460(+) A-I      intronic chr19:24274994(+) A-I      intronic chr19:24275043(+) A-I      intronic chr19:24275137(+) A-I      intronic chr19:24280394(+) A-I      intronic chr19:24280462(+) A-I      intronic chr19:24283803(+) A-I      intronic chr19:24283796(+) A-I      intronic chr19:24273917(+) A-I      intronic chr19:24302196(+) A-I      intronic chr19:24302182(+) A-I      intronic chr19:24302094(+) A-I      intronic chr19:24301834(+) A-I      intronic chr19:24283818(+) A-I      intronic chr19:24301792(+) A-I      intronic chr19:24301645(+) A-I      intronic chr19:24293101(+) A-I      intronic chr19:24275138(+) A-I      intronic chr19:24283769(+) A-I      intronic chr19:24280463(+) A-I      intronic chr19:24292740(+) A-I      intronic chr19:24271576(+) A-I      intronic chr19:24273264(+) A-I      intronic chr19:24273365(+) A-I      intronic chr19:24273380(+) A-I      intronic chr19:24273413(+) A-I      intronic chr19:24273428(+) A-I      intronic chr19:24273855(+) A-I      intronic chr19:24273916(+) A-I      intronic chr19:24273378(+) A-I      intronic chr19:24271624(+) A-I      intronic chr19:24273338(+) A-I      intronic chr19:24301728(+) A-I      intronic chr19:24280428(+) A-I      intronic chr19:24274316(+) A-I      intronic chr19:24273948(+) A-I      intronic chr19:24274021(+) A-I      intronic chr19:24270978(+) A-I      intronic chr19:24273439(+) A-I      intronic chr19:24271944(+) A-I      intronic chr19:24273356(+) A-I      intronic chr19:24273419(+) A-I      intronic chr19:24300982(+) A-I      intronic chr19:24293082(+) A-I      intronic chr19:24301794(+) A-I      intronic chr19:24280328(+) A-I      intronic chr19:24277156(+) A-I      intronic chr19:24273956(+) A-I      intronic chr19:24301659(+) A-I      intronic chr19:24273459(+) A-I      intronic chr19:24301826(+) A-I      intronic chr19:24274424(+) A-I      intronic chr19:24302483(+) A-I      intronic chr19:24300876(+) A-I      intronic chr19:24274429(+) A-I      intronic chr19:24273474(+) A-I      intronic chr19:24280359(+) A-I      intronic chr19:24301705(+) A-I      intronic chr19:24273014(+) A-I      intronic chr19:24301833(+) A-I      intronic chr19:24301036(+) A-I      intronic chr19:24272070(+) A-I      intronic chr19:24272889(+) A-I      intronic chr19:24273925(+) A-I      intronic chr19:24272869(+) A-I      intronic chr19:24302093(+) A-I      intronic chr19:24280433(+) A-I      intronic chr19:24272901(+) A-I      intronic chr19:24273319(+) A-I      intronic chr19:24272893(+) A-I      intronic chr19:24293319(+) A-I      intronic chr19:24301664(+) A-I      intronic chr19:24293302(+) A-I      intronic chr19:24301115(+) A-I      intronic chr19:24302049(+) A-I      intronic chr19:24272803(+) A-I      intronic chr19:24271558(+) A-I      intronic chr19:24302087(+) A-I      intronic chr19:24301741(+) A-I      intronic chr19:24301828(+) A-I      intronic chr19:24301793(+) A-I      intronic chr19:24271584(+) A-I      intronic chr19:24271721(+) A-I      intronic chr19:24272763(+) A-I      intronic chr19:24272879(+) A-I      intronic chr19:24273931(+) A-I      intronic chr19:24273831(+) A-I      intronic chr19:24275049(+) A-I      intronic chr19:24302123(+) A-I      intronic chr19:24300995(+) A-I      intronic chr19:24302246(+) A-I      intronic chr19:24274395(+) A-I      intronic chr19:24292669(+) A-I      intronic chr19:24293156(+) A-I      intronic chr19:24286553(+) A-I      intronic chr19:24271679(+) A-I      intronic chr19:24272777(+) A-I      intronic chr19:24301658(+) A-I      intronic chr19:24301747(+) A-I      intronic chr19:24280504(+) A-I      intronic chr19:24301736(+) A-I      intronic chr19:24301056(+) A-I      intronic chr19:24301116(+) A-I      intronic chr19:24273368(+) A-I      intronic chr19:24273444(+) A-I      intronic chr19:24272880(+) A-I      intronic chr19:24280398(+) A-I      intronic chr19:24302098(+) A-I      intronic chr19:24302053(+) A-I      intronic chr19:24273880(+) A-I      intronic chr19:24280528(+) A-I      intronic chr19:24272965(+) A-I      intronic chr19:24274317(+) A-I      intronic chr19:24292653(+) A-I      intronic chr19:24292601(+) A-I      intronic chr19:24273825(+) A-I      intronic chr19:24273854(+) A-I      intronic chr19:24271687(+) A-I      intronic chr19:24301877(+) A-I      intronic chr19:24272915(+) A-I      intronic chr19:24272738(+) A-I      intronic chr19:24272781(+) A-I      intronic chr19:24272848(+) A-I      intronic chr19:24293320(+) A-I      intronic chr19:24291836(+) A-I      intronic chr19:24303681(+) A-I      intronic chr19:24273364(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZNF254	chr19:24273444(+) A-G intron -    22484847 chr19:24301650(+) A-G intron -    22484847 chr19:24301652(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF254	chr19:24216334-24216335(+) m6A 5'UTR       24981863 chr19:24216401-24216402(+) m6A 5'UTR       24981863 chr19:24248331-24248332(+) m6A intron       24981863 chr19:24248337-24248338(+) m6A intron       24981863 chr19:24290139-24290140(+) m6A 3'UTR//exon//intron       22608085 chr19:24309079-24309080(+) m6A 3'UTR//CDS       24981863//22608085 chr19:24309149-24309150(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr19:24309205-24309206(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr19:24309224-24309225(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr19:24309310-24309311(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr19:24309326-24309327(+) m6A 3'UTR//CDS       24981863//22608085 chr19:24309393-24309394(+) m6A CDS       24981863//22608085 chr19:24309453-24309454(+) m6A CDS       24981863//22608085 chr19:24309509-24309510(+) m6A CDS       24981863//22608085 chr19:24309593-24309594(+) m6A CDS       24981863//22608085 chr19:24309677-24309678(+) m6A CDS       24981863//22608085 chr19:24309761-24309762(+) m6A CDS       22608085 chr19:24309818-24309819(+) m6A CDS       24981863//22608085 chr19:24309845-24309846(+) m6A CDS       22608085 chr19:24310013-24310014(+) m6A CDS       24981863//22608085 chr19:24310097-24310098(+) m6A CDS       24981863//22608085 chr19:24310154-24310155(+) m6A CDS       24981863//22608085 chr19:24310181-24310182(+) m6A CDS       24981863//22608085 chr19:24310238-24310239(+) m6A CDS       24981863//22608085 chr19:24310265-24310266(+) m6A CDS       24981863//22608085 chr19:24310349-24310350(+) m6A CDS       24981863//22608085 chr19:24310406-24310407(+) m6A CDS       24981863//22608085 chr19:24310433-24310434(+) m6A CDS       24981863//22608085 chr19:24310517-24310518(+) m6A CDS       24981863//22608085 chr19:24310574-24310575(+) m6A CDS       24981863//22608085 chr19:24310601-24310602(+) m6A CDS       24284625//24981863//22608085 chr19:24310658-24310659(+) m6A CDS       24284625//24981863//22608085 chr19:24310805-24310806(+) m6A 3'UTR       24284625//24981863//22608085 chr19:24310850-24310851(+) m6A 3'UTR       24284625//24981863//22608085 chr19:24310857-24310858(+) m6A 3'UTR       24284625//24981863//22608085 chr19:24310895-24310896(+) m6A 3'UTR       24284625//24981863//22608085 chr19:24311006-24311007(+) m6A 3'UTR       24284625//24981863//22608085 chr19:24311019-24311020(+) m6A 3'UTR       24284625//24981863//22608085 chr19:24311251-24311252(+) m6A 3'UTR       24981863 chr19:24311330-24311331(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30a-3p	Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Endothelial cells|Epithelial cells|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Serum     24797360 Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	ZNF254	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30a-3p	Sorafenib 216239 Drug interaction    RC00000903

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30a-3p	Imatinib 5291       25349971

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30a-3p
Interactor2: ZNF254

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.