Detail Information

Basic Information:


  VIRBase ID:  

HHID00044880

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30a-3p:           PRKAA1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30a-3p PRKAA1
miRBase
Accession/Entrez ID		 MIMAT0000088 5562
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AMPK//AMPKa1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30a-3p
rs149150037 chr6:71403567    G/A
rs149150037 chr6:71403567    G/C
rs370184894 chr6:71403566    C/A
rs370184894 chr6:71403566    C/T
rs552541514 chr6:71403558    C/G
rs745605208 chr6:71403563    ATCCG/A
rs746505574 chr6:71403557    G/A
rs746505574 chr6:71403557    G/T
rs746965145 chr6:71403554    GCT/G
rs750918072 chr6:71403564    T/C
rs765735953 chr6:71403560    A/T
rs770865356 chr6:71403559    A/AC
rs776574456 chr6:71403560    A/AAGCTGGAGT
rs368070339 chr6:71403571    G/A
rs769702885 chr6:71403570    TG/T
rs775921090 chr6:71403574    AGCC/A
rs781617967 chr6:71403573    A/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PRKAA1
chr5:40770799(-) A-I      intronic
chr5:40777930(-) A-I      intronic
chr5:40785479(-) A-I      intronic
chr5:40785524(-) A-I      intronic
chr5:40789091(-) A-I      intronic
chr5:40789096(-) A-I      intronic
chr5:40789121(-) A-I      intronic
chr5:40789147(-) A-I      intronic
chr5:40789256(-) A-I      intronic
chr5:40789307(-) A-I      intronic
chr5:40777844(-) A-I      intronic
chr5:40770805(-) A-I      intronic
chr5:40770541(-) A-I      intronic
chr5:40770485(-) A-I      intronic
chr5:40770373(-) A-I      intronic
chr5:40789230(-) A-I      intronic
chr5:40770360(-) A-I      intronic
chr5:40789141(-) A-I      intronic
chr5:40779030(-) A-I      intronic
chr5:40762291(-) A-I      3'UTR
chr5:40762262(-) A-I      3'UTR
chr5:40762190(-) A-I      3'UTR
chr5:40762141(-) A-I      3'UTR
chr5:40762181(-) A-I      3'UTR
chr5:40789056(-) A-I      intronic
chr5:40770492(-) A-I      intronic
chr5:40777394(-) A-I      intronic
chr5:40788781(-) A-I      intronic
chr5:40785615(-) A-I      intronic
chr5:40778230(-) A-I      intronic
chr5:40771493(-) A-I      intronic
chr5:40764153(-) A-I      ncRNA
chr5:40762119(-) A-I      3'UTR
chr5:40770561(-) A-I      intronic
chr5:40770822(-) A-I      intronic
chr5:40767245(-) A-I      intronic
chr5:40772868(-) A-I      intronic
chr5:40770832(-) A-I      intronic
chr5:40772900(-) A-I      intronic
chr5:40785624(-) A-I      intronic
chr5:40777152(-) A-I      intronic
chr5:40779125(-) A-I      intronic
chr5:40786945(-) A-I      intronic
chr5:40767246(-) A-I      intronic
chr5:40770321(-) A-I      intronic
chr5:40779156(-) A-I      intronic
chr5:40772978(-) A-I      intronic
chr5:40785610(-) A-I      intronic
chr5:40770308(-) A-I      intronic
chr5:40770347(-) A-I      intronic
chr5:40766907(-) A-I      intronic
chr5:40777791(-) A-I      intronic
chr5:40779096(-) A-I      intronic
chr5:40779097(-) A-I      intronic
chr5:40766917(-) A-I      intronic
chr5:40764149(-) A-I      ncRNA
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PRKAA1
chr5:40762119(-) A-G exon 3'UTR    22484847
chr5:40770720(-) T-C intron -    22484847
chr5:40777394(-) A-G intron -    22484847
chr5:40785610(-) A-G intron -    22484847
chr5:40789299(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PRKAA1
chr5:40760600-40760601(-) m6A 3'UTR       24981863
chr5:40760879-40760880(-) m6A 3'UTR       24981863//26404942//22608085
chr5:40761318-40761319(-) m6A 3'UTR       26404942
chr5:40761998-40761999(-) m6A 3'UTR       27773535
chr5:40762037-40762038(-) m6A 3'UTR       27773535
chr5:40762871-40762872(-) m6A 3'UTR       24981863//27773535//22608085
chr5:40762878-40762879(-) m6A 3'UTR       24981863//27773535//22608085
chr5:40762945-40762946(-) m6A CDS       24284625//24981863//27773535//22608085
chr5:40763083-40763084(-) Gm CDS       -
chr5:40763097-40763098(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr5:40764582-40764583(-) m6A exon//intron       24284625//24981863//27773535
chr5:40764596-40764597(-) m6A exon//intron       24284625//24981863//26404942//27773535//22608085
chr5:40764645-40764646(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085
chr5:40764734-40764735(-) m6A CDS//exon       24284625
chr5:40764874-40764875(-) m6A CDS//exon       24284625
chr5:40764967-40764968(-) m6A CDS//exon       24284625
chr5:40765017-40765018(-) m6A CDS//exon       24284625//22608085
chr5:40777680-40777681(-) m6A CDS//exon       24981863//27371828//22575960
chr5:40798240-40798241(-) m6A CDS//exon       24284625//25456834//24981863//27371828//22575960
chr5:40798282-40798283(-) m6A CDS//exon       24284625//25456834//24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30a-3p
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Endothelial cells|Epithelial cells|Tongue tissue     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Serum     24797360
Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
PRKAA1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HeLa-S3 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30a-3p
Sorafenib 216239 Drug interaction    RC00000903
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-30a-3p
Imatinib 5291       25349971

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30a-3p
Interactor2: PRKAA1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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