Detail Information

Basic Information:


  VIRBase ID:  

HHID00044875

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30a-3p:           KRAS:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30a-3p KRAS
miRBase
Accession/Entrez ID		 MIMAT0000088 3845
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - 'C-K-RAS//C-K-RAS//c-Ki-ras//c-Ki-ras2//CFC2//K-Ras//K-Ras 2//K-RAS2A//K-RAS2B//K-RAS4A//K-RAS4B//KI-RAS//KRAS1//KRAS2//NS//NS3//OES//RALD//RASK2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30a-3p
rs149150037 chr6:71403567    G/A
rs149150037 chr6:71403567    G/C
rs370184894 chr6:71403566    C/A
rs370184894 chr6:71403566    C/T
rs552541514 chr6:71403558    C/G
rs745605208 chr6:71403563    ATCCG/A
rs746505574 chr6:71403557    G/A
rs746505574 chr6:71403557    G/T
rs746965145 chr6:71403554    GCT/G
rs750918072 chr6:71403564    T/C
rs765735953 chr6:71403560    A/T
rs770865356 chr6:71403559    A/AC
rs776574456 chr6:71403560    A/AAGCTGGAGT
rs368070339 chr6:71403571    G/A
rs769702885 chr6:71403570    TG/T
rs775921090 chr6:71403574    AGCC/A
rs781617967 chr6:71403573    A/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR KRAS
chr12:25364397(-) A-I      intronic
chr12:25384258(-) A-I      intronic
chr12:25384200(-) A-I      intronic
chr12:25372046(-) A-I      intronic
chr12:25384290(-) A-I      intronic
chr12:25374360(-) A-I      intronic
chr12:25384190(-) A-I      intronic
chr12:25374361(-) A-I      intronic
chr12:25384240(-) A-I      intronic
chr12:25374327(-) A-I      intronic
chr12:25372011(-) A-I      intronic
chr12:25374275(-) A-I      intronic
chr12:25384234(-) A-I      intronic
chr12:25372052(-) A-I      intronic
chr12:25372051(-) A-I      intronic
chr12:25372048(-) A-I      intronic
chr12:25372037(-) A-I      intronic
chr12:25372042(-) A-I      intronic
chr12:25372043(-) A-I      intronic
chr12:25383424(-) A-I      intronic
chr12:25383462(-) A-I      intronic
chr12:25374331(-) A-I      intronic
chr12:25383413(-) A-I      intronic
chr12:25383360(-) A-I      intronic
chr12:25382978(-) A-I      intronic
chr12:25382867(-) A-I      intronic
chr12:25382827(-) A-I      intronic
chr12:25381858(-) A-I      intronic
chr12:25374975(-) A-I      intronic
chr12:25384132(-) A-I      intronic
chr12:25401045(-) A-I      intronic
chr12:25401203(-) A-I      intronic
chr12:25365438(-) A-I      intronic
chr12:25374971(-) A-I      intronic
chr12:25383515(-) A-I      intronic
chr12:25370746(-) A-I      intronic
chr12:25381830(-) A-I      intronic
chr12:25372001(-) A-I      intronic
chr12:25374258(-) A-I      intronic
chr12:25383499(-) A-I      intronic
chr12:25374264(-) A-I      intronic
chr12:25381750(-) A-I      intronic
chr12:25382964(-) A-I      intronic
chr12:25382915(-) A-I      intronic
chr12:25374961(-) A-I      intronic
chr12:25370728(-) A-I      intronic
chr12:25383418(-) A-I      intronic
chr12:25382779(-) A-I      intronic
chr12:25383510(-) A-I      intronic
chr12:25402183(-) A-I      intronic
chr12:25369459(-) A-I      intronic
chr12:25399380(-) A-I      intronic
chr12:25374252(-) A-I      intronic
chr12:25370742(-) A-I      intronic
chr12:25365781(-) A-I      intronic
chr12:25381735(-) A-I      intronic
chr12:25371969(-) A-I      intronic
chr12:25370776(-) A-I      intronic
chr12:25374400(-) A-I      intronic
chr12:25374342(-) A-I      intronic
chr12:25383306(-) A-I      intronic
chr12:25374234(-) A-I      intronic
chr12:25383493(-) A-I      intronic
chr12:25383365(-) A-I      intronic
chr12:25369311(-) A-I      intronic
chr12:25374263(-) A-I      intronic
chr12:25384160(-) A-I      intronic
chr12:25365830(-) A-I      intronic
chr12:25369468(-) A-I      intronic
chr12:25365829(-) A-I      intronic
chr12:25374304(-) A-I      intronic
chr12:25364479(-) A-I      intronic
chr12:25374395(-) A-I      intronic
chr12:25365845(-) A-I      intronic
chr12:25365441(-) A-I      intronic
chr12:25365803(-) A-I      intronic
chr12:25365735(-) A-I      intronic
chr12:25382886(-) A-I      intronic
chr12:25384213(-) A-I      intronic
chr12:25382928(-) A-I      intronic
chr12:25384174(-) A-I      intronic
chr12:25374256(-) A-I      intronic
chr12:25374423(-) A-I      intronic
chr12:25383480(-) A-I      intronic
chr12:25384289(-) A-I      intronic
chr12:25365741(-) A-I      intronic
chr12:25381825(-) A-I      intronic
chr12:25373896(-) A-I      intronic
chr12:25374290(-) A-I      intronic
chr12:25365415(-) A-I      intronic
chr12:25365746(-) A-I      intronic
chr12:25370828(-) A-I      intronic
chr12:25382935(-) A-I      intronic
chr12:25383479(-) A-I      intronic
chr12:25374935(-) A-I      intronic
chr12:25374371(-) A-I      intronic
chr12:25369347(-) A-I      intronic
chr12:25384184(-) A-I      intronic
chr12:25374340(-) A-I      intronic
chr12:25374895(-) A-I      intronic
chr12:25401160(-) A-I      intronic
chr12:25384248(-) A-I      intronic
chr12:25381776(-) A-I      intronic
chr12:25374372(-) A-I      intronic
chr12:25364422(-) A-I      intronic
chr12:25401321(-) A-I      intronic
chr12:25383557(-) A-I      intronic
chr12:25383559(-) A-I      intronic
chr12:25374295(-) A-I      intronic
chr12:25372145(-) A-I      intronic
chr12:25401161(-) A-I      intronic
chr12:25382940(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED KRAS
chr12:25365741(-) A-I intron -    21960545   //22327324
chr12:25365781(-) A-I intron -    21960545   //22327324
chr12:25365415(-) A-I intron -    21960545
chr12:25365416(-) A-I intron -    21960545
chr12:25365829(-) A-I intron -    21960545
chr12:25365830(-) A-I intron -    21960545
chr12:25365833(-) A-I intron -    21960545
chr12:25369307(-) A-I intron -    21960545
chr12:25369341(-) A-I intron -    21960545
chr12:25369347(-) A-I intron -    21960545
chr12:25370623(-) A-I intron -    21960545
chr12:25370728(-) A-I intron -    21960545
chr12:25370746(-) A-I intron -    21960545
chr12:25370776(-) A-I intron -    21960545
chr12:25370828(-) A-I intron -    21960545
chr12:25382901(-) A-I intron -    21960545
chr12:25383306(-) A-I intron -    21960545
chr12:25383424(-) A-I intron -    21960545
chr12:25383557(-) A-I intron -    21960545
chr12:25360448(-) G-T exon 3'UTR    22484847
chr12:25360449(-) G-T exon 3'UTR    22484847
chr12:25365741(-) A-G intron -    22484847
chr12:25365781(-) A-G intron -    22484847
chr12:25365958(-) T-C intron -    22484847
chr12:25374244(-) T-C intron -    22484847
chr12:25382928(-) A-G intron -    22484847
chr12:25382935(-) A-G intron -    22484847
chr12:25383480(-) A-G intron -    22484847
chr12:25369303(-) T-C intron -    22484847
chr12:25370828(-) A-G intron -    22484847
chr12:25372145(-) A-G intron -    22484847
chr12:25374395(-) A-G intron -    22484847
chr12:25374400(-) A-G intron -    22484847
chr12:25374423(-) A-G intron -    22484847
chr12:25374895(-) A-G intron -    22484847
chr12:25382780(-) T-C intron -    22484847
chr12:25383365(-) A-G intron -    22484847
chr12:25383479(-) A-G intron -    22484847
chr12:25383493(-) A-G intron -    22484847
chr12:25383510(-) A-G intron -    22484847
chr12:25384160(-) A-G intron -    22484847
chr12:25384184(-) A-G intron -    22484847
chr12:25401160(-) A-G intron -    22484847
chr12:25401161(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase KRAS
chr12:25362748-25362749(-) m6A 3'UTR//CDS       24981863//27773535
chr12:25362800-25362801(-) m6A 3'UTR//CDS       24981863//27773535//27371828
chr12:25368415-25368416(-) m6A CDS//intron       27773535//27371828
chr12:25378550-25378551(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378555-25378556(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378567-25378568(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378602-25378603(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378613-25378614(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378620-25378621(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378627-25378628(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378683-25378684(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378703-25378704(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25380237-25380238(-) m6A CDS//intron       24981863//26404942//27773535
chr12:25380251-25380252(-) m6A CDS//intron       24981863//26404942//27773535
chr12:25380309-25380310(-) m6A CDS//intron       24981863//26404942//27773535
chr12:25387487-25387488(-) m6A 3'UTR//intron       27773535
chr12:25387524-25387525(-) m6A 3'UTR//intron       27773535
chr12:25398303-25398304(-) m6A CDS       24209618//27371828
chr12:25403761-25403762(-) m6A 5'UTR       24209618//24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30a-3p
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Endothelial cells|Epithelial cells|Tongue tissue     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Serum     24797360
Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
KRAS
Chromatin K562 cells     -
Exosome Serum     -
Mitochondrion HDF cells     16178658
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30a-3p
Sorafenib 216239 Drug interaction    RC00000903
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-30a-3p
Imatinib 5291       25349971

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30a-3p
Interactor2: KRAS

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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