Detail Information

Basic Information:


  VIRBase ID:  

HHID00044873

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30a-3p:           S1PR1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30a-3p S1PR1
miRBase
Accession/Entrez ID		 MIMAT0000088 1901
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CD363//CHEDG1//D1S3362//ECGF1//EDG-1//EDG1//S1P1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30a-3p
rs149150037 chr6:71403567    G/A
rs149150037 chr6:71403567    G/C
rs370184894 chr6:71403566    C/A
rs370184894 chr6:71403566    C/T
rs552541514 chr6:71403558    C/G
rs745605208 chr6:71403563    ATCCG/A
rs746505574 chr6:71403557    G/A
rs746505574 chr6:71403557    G/T
rs746965145 chr6:71403554    GCT/G
rs750918072 chr6:71403564    T/C
rs765735953 chr6:71403560    A/T
rs770865356 chr6:71403559    A/AC
rs776574456 chr6:71403560    A/AAGCTGGAGT
rs368070339 chr6:71403571    G/A
rs769702885 chr6:71403570    TG/T
rs775921090 chr6:71403574    AGCC/A
rs781617967 chr6:71403573    A/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase S1PR1
chr1:101702480-101702481(+) m6A 5'UTR       -
chr1:101702499-101702500(+) m6A 5'UTR//exon       -
chr1:101702535-101702536(+) m6A 5'UTR//exon       -
chr1:101704658-101704659(+) m6A CDS//exon       22608085
chr1:101704667-101704668(+) m6A CDS//exon       24981863//22608085
chr1:101704677-101704678(+) m6A CDS//exon       24981863//22608085
chr1:101704727-101704728(+) m6A CDS//exon       24981863//22608085
chr1:101704756-101704757(+) m6A CDS//exon       24981863//22608085
chr1:101704811-101704812(+) m6A CDS//exon       24981863//22608085
chr1:101704989-101704990(+) m6A CDS//exon       24981863//22608085
chr1:101705087-101705088(+) m6A CDS       24981863//22608085
chr1:101705227-101705228(+) m6A CDS       24981863
chr1:101705258-101705259(+) m6A CDS       24981863
chr1:101705308-101705309(+) m6A CDS       -
chr1:101705395-101705396(+) m6A CDS       -
chr1:101705543-101705544(+) m6A CDS       25456834//24981863//22575960//22608085
chr1:101705606-101705607(+) m6A CDS       25456834//24981863//22575960//22608085
chr1:101705639-101705640(+) m6A CDS       25456834//24981863//22575960//22608085
chr1:101705650-101705651(+) m6A CDS       25456834//24981863//22608085
chr1:101705690-101705691(+) m6A 3'UTR       25456834//24981863//22608085
chr1:101705828-101705829(+) m6A 3'UTR       25456834//24981863//22608085
chr1:101705875-101705876(+) m6A 3'UTR       25456834//24981863//22608085
chr1:101706012-101706013(+) m6A 3'UTR       24981863
chr1:101706085-101706086(+) m6A 3'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30a-3p
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Endothelial cells|Epithelial cells|Tongue tissue     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Serum     24797360
Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
S1PR1
Cytosol HeLa-S3 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30a-3p
Sorafenib 216239 Drug interaction    RC00000903
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-30a-3p
Imatinib 5291       25349971

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30a-3p
Interactor2: S1PR1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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