Basic Information:

  VIRBase ID:  

HHID00044871

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30a-3p:  MIMAT0000088          DDX3X:  NR_126094     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30a-3p	DDX3X
miRBase Accession/Entrez ID	MIMAT0000088	1654
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CAP-Rf//DBX//DDX14//DDX3//HLP2//MRX102//MRXSSB

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30a-3p	rs149150037 chr6:71403567    G/A rs149150037 chr6:71403567    G/C rs370184894 chr6:71403566    C/A rs370184894 chr6:71403566    C/T rs552541514 chr6:71403558    C/G rs745605208 chr6:71403563    ATCCG/A rs746505574 chr6:71403557    G/A rs746505574 chr6:71403557    G/T rs746965145 chr6:71403554    GCT/G rs750918072 chr6:71403564    T/C rs765735953 chr6:71403560    A/T rs770865356 chr6:71403559    A/AC rs776574456 chr6:71403560    A/AAGCTGGAGT rs368070339 chr6:71403571    G/A rs769702885 chr6:71403570    TG/T rs775921090 chr6:71403574    AGCC/A rs781617967 chr6:71403573    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DDX3X	chrX:41200368(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DDX3X	chrX:41192893-41192894(+) m6A 5'UTR//exon       24981863 chrX:41192928-41192929(+) m6A 5'UTR//exon       24981863//27773535 chrX:41192942-41192943(+) m1A 5'UTR//exon       26863196 chrX:41192973-41192974(+) m6A 5'UTR//exon//intron       24981863//27773535 chrX:41192979-41192980(+) m6A 5'UTR//exon//intron       24981863//27773535 chrX:41193134-41193135(+) m6A 5'UTR//intron       24284625//24209618//24981863 chrX:41193148-41193149(+) m6A 5'UTR//intron       24284625//24209618//24981863 chrX:41193191-41193192(+) m6A 5'UTR//intron       24284625//24209618//24981863 chrX:41193197-41193198(+) m6A 5'UTR//intron       24284625//24209618//24981863 chrX:41193229-41193230(+) m6A 5'UTR//intron       24284625//24981863 chrX:41193247-41193248(+) m6A 5'UTR//intron       24284625//24981863 chrX:41193274-41193275(+) m6A 5'UTR//intron       24284625//24981863 chrX:41193453-41193454(+) m6A 5'UTR//exon//intron       24284625//25456834//24981863//26404942//22575960//22608085 chrX:41193478-41193479(+) m6A 5'UTR//exon//intron       24284625//25456834//24981863//26404942//27773535//22575960//22608085 chrX:41193542-41193543(+) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//22575960//22608085 chrX:41193982-41193983(+) m6A exon//intron       24981863 chrX:41196673-41196674(+) m6A CDS//exon       24284625//24981863 chrX:41196679-41196680(+) m6A CDS//exon       24284625//24981863 chrX:41198318-41198319(+) m6A CDS//exon//intron       24981863//26404942 chrX:41200751-41200752(+) m6A CDS//exon       24981863//26404942//22575960 chrX:41201833-41201834(+) m6A CDS//exon//intron       22575960 chrX:41201876-41201877(+) m6A CDS//exon//intron       22575960 chrX:41201903-41201904(+) m6A CDS//exon//intron       22575960 chrX:41201992-41201993(+) m6A CDS//exon//intron       22575960 chrX:41202505-41202506(+) m6A CDS//exon//intron       26404942//22575960 chrX:41203308-41203309(+) m6A CDS//exon//intron       22575960 chrX:41203561-41203562(+) m6A CDS//exon//intron       22575960 chrX:41203642-41203643(+) m6A CDS//exon//intron       22575960 chrX:41204504-41204505(+) m6A CDS//exon//intron       22575960 chrX:41206226-41206227(+) m6A CDS//intron       26404942 chrX:41206596-41206597(+) m6A CDS//intron       24209618//26404942//22575960 chrX:41207001-41207002(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:41207017-41207018(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:41207037-41207038(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:41207061-41207062(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:41207144-41207145(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:41207179-41207180(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22608085 chrX:41207231-41207232(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22608085 chrX:41207296-41207297(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535 chrX:41207373-41207374(+) m6A 3'UTR//intron       26404942//27773535 chrX:41207390-41207391(+) m6A 3'UTR//intron       26404942//27773535 chrX:41207459-41207460(+) m6A 3'UTR//intron       26404942 chrX:41207512-41207513(+) m6A 3'UTR//intron       26404942//27773535 chrX:41207562-41207563(+) m6A 3'UTR//intron       26404942//27773535 chrX:41207986-41207987(+) m6A 3'UTR//intron       22575960 chrX:41208065-41208066(+) m6A 3'UTR//intron       22575960 chrX:41208946-41208947(+) m6A 3'UTR//intron       27773535 chrX:41208968-41208969(+) m6A 3'UTR//intron       27773535 chrX:41209013-41209014(+) m6A 3'UTR//intron       27773535 chrX:41209081-41209082(+) m6A 3'UTR//intron       27773535 chrX:41209091-41209092(+) m6A 3'UTR//intron       27773535 chrX:41209199-41209200(+) m6A 3'UTR//intron       27773535 chrX:41209327-41209328(+) m6A 3'UTR//intron       27773535 chrX:41209349-41209350(+) m6A 3'UTR//intron       27773535 chrX:41209451-41209452(+) m6A 3'UTR//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30a-3p	Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Endothelial cells|Epithelial cells|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Serum     24797360 Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	DDX3X	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30a-3p	Sorafenib 216239 Drug interaction    RC00000903

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30a-3p	Imatinib 5291       25349971

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30a-3p
Interactor2: DDX3X

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.