Detail Information

Basic Information:


  VIRBase ID:  

HHID00044866

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30a-3p:           CCND2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30a-3p CCND2
miRBase
Accession/Entrez ID		 MIMAT0000088 894
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - KIAK0002//MPPH3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30a-3p
rs149150037 chr6:71403567    G/A
rs149150037 chr6:71403567    G/C
rs370184894 chr6:71403566    C/A
rs370184894 chr6:71403566    C/T
rs552541514 chr6:71403558    C/G
rs745605208 chr6:71403563    ATCCG/A
rs746505574 chr6:71403557    G/A
rs746505574 chr6:71403557    G/T
rs746965145 chr6:71403554    GCT/G
rs750918072 chr6:71403564    T/C
rs765735953 chr6:71403560    A/T
rs770865356 chr6:71403559    A/AC
rs776574456 chr6:71403560    A/AAGCTGGAGT
rs368070339 chr6:71403571    G/A
rs769702885 chr6:71403570    TG/T
rs775921090 chr6:71403574    AGCC/A
rs781617967 chr6:71403573    A/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CCND2
chr12:4407683(+) A-I      intronic
chr12:4406504(+) A-I      intronic
chr12:4408273(+) A-I      intronic
chr12:4408319(+) A-I      intronic
chr12:4407661(+) A-I      intronic
chr12:4408272(+) A-I      intronic
chr12:4406535(+) A-I      intronic
chr12:4408325(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CCND2
chr12:4406341(+) A-T intron -    22484847
chr12:4406592(+) C-T intron -    22484847
chr12:4406734(+) C-T intron -    22484847
chr12:4406735(+) T-C intron -    22484847
chr12:4406736(+) C-A intron -    22484847
chr12:4407661(+) A-G intron -    22484847
chr12:4404682(+) T-C intron -    22484847
chr12:4408272(+) A-G intron -    22484847
chr12:4408273(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CCND2
chr12:4382959-4382960(+) m6A 5'UTR       25456834//24981863
chr12:4382977-4382978(+) m6A 5'UTR       25456834//24981863
chr12:4383080-4383081(+) m6A 5'UTR       25456834//24981863
chr12:4383140-4383141(+) m6A 5'UTR       24981863
chr12:4383146-4383147(+) m6A 5'UTR       -
chr12:4383154-4383155(+) m6A 5'UTR       -
chr12:4409504-4409505(+) m6A 3'UTR       22608085
chr12:4409518-4409519(+) m6A 3'UTR       24981863//22608085
chr12:4409578-4409579(+) m6A 3'UTR       24209618//24981863//22608085
chr12:4409622-4409623(+) m6A 3'UTR       24209618//24981863//22608085
chr12:4409650-4409651(+) m6A 3'UTR       24209618//24981863//22608085
chr12:4409673-4409674(+) m6A 3'UTR       24209618//24981863//22608085
chr12:4409694-4409695(+) m6A 3'UTR       24209618//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30a-3p
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Endothelial cells|Epithelial cells|Tongue tissue     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Serum     24797360
Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
CCND2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30a-3p
Sorafenib 216239 Drug interaction    RC00000903
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-30a-3p
Imatinib 5291       25349971

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30a-3p
Interactor2: CCND2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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