Detail Information

Basic Information:


  VIRBase ID:  

HHID00044435

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-28-5p:           IER3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-28-5p IER3
miRBase
Accession/Entrez ID		 MIMAT0000085 8870
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DIF-2//DIF2//GLY96//IEX-1//IEX-1L//IEX1//PRG1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-28-5p
rs1211406812 chr3:188688805    A/T
rs1315387654 chr3:188688811    T/G
rs1333243027 chr3:188688802    C/A
rs1350747725 chr3:188688807    T/C
rs1380324091 chr3:188688806    G/A
rs1380847802 chr3:188688813    G/GGGAA
rs564264103 chr3:188688810    A/G
rs1466099417 chr3:188688800    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IER3
chr6:30711003-30711004(-) m6A 3'UTR       24284625//27773535
chr6:30711027-30711028(-) Gm 3'UTR       -
chr6:30711135-30711136(-) m6A 3'UTR       24284625//24209618//27773535
chr6:30711145-30711146(-) m6A 3'UTR       24284625//24209618//27773535
chr6:30711255-30711256(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr6:30711287-30711288(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr6:30711296-30711297(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr6:30711311-30711312(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085
chr6:30711525-30711526(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr6:30711541-30711542(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:30711557-30711558(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:30711595-30711596(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:30711602-30711603(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:30711620-30711621(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:30711663-30711664(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:30711674-30711675(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:30711752-30711753(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:30711764-30711765(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:30711941-30711942(-) m6A CDS       24284625//24209618//27773535//22575960
chr6:30711946-30711947(-) m6A CDS       24284625//24209618//27773535//22575960
chr6:30712217-30712218(-) m6A CDS       24284625//25456834//24981863//27371828//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-28-5p
Cytoplasm Neural progenitor cells     21363885
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Seminal fluid     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
IER3
Cytosol HCC cell line (HepG2)     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-28-5p
Kinetin riboside 20345 Drug resistant
michicarcin - Drug resistant
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-28-5p
Formaldehyde 712 Drug interaction    RC00000838
Gemcitabine 60750 Drug interaction    RC00000844
Morphine 5288826 Drug interaction    RC00000848
Cholecalciferol 5280795 Drug interaction    RC00000847
Decitabine 451668 Drug interaction    RC00000846
Epirubicin 41867 Drug interaction    RC00000843
Paclitaxel 36314 Drug interaction    RC00000842
Doxorubicin 31703 Drug interaction    RC00000841
Verapamil 2520 Drug interaction    RC00000839
Ginsenoside Rh2 119307 Drug interaction    RC00000845
Methamphetamine 10836 Drug interaction    RC00000840
Trastuzumab - Drug interaction    RC00000849
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-28-5p
Imatinib 5291       30249101
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-28-5p
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Paclitaxel       36314
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-28-5p
Interactor2: IER3

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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