Basic Information:

  VIRBase ID:  

HHID00044167

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-26b-5p:  MIMAT0000083          NUDT19:  NM_001105570     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-26b-5p	NUDT19
miRBase Accession/Entrez ID	MIMAT0000083	390916
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	RP2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-26b-5p	rs1173404354 chr2:218402668    C/T rs1381090830 chr2:218402673    T/C rs1417663771 chr2:218402671    G/A rs1417663771 chr2:218402671    G/C rs1434330126 chr2:218402675    G/A rs766205860 chr2:218402672    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NUDT19	chr19:33193446(+) A-I      intronic chr19:33191582(+) A-I      intronic chr19:33191617(+) A-I      intronic chr19:33193442(+) A-I      intronic chr19:33192366(+) A-I      intronic chr19:33192824(+) A-I      intronic chr19:33192873(+) A-I      intronic chr19:33204131(+) A-I      3'UTR chr19:33195902(+) A-I      intronic chr19:33192808(+) A-I      intronic chr19:33196166(+) A-I      intronic chr19:33196162(+) A-I      intronic chr19:33196128(+) A-I      intronic chr19:33195925(+) A-I      intronic chr19:33193463(+) A-I      intronic chr19:33191843(+) A-I      intronic chr19:33195886(+) A-I      intronic chr19:33195882(+) A-I      intronic chr19:33195866(+) A-I      intronic chr19:33193469(+) A-I      intronic chr19:33203004(+) A-I      3'UTR chr19:33193464(+) A-I      intronic chr19:33193459(+) A-I      intronic chr19:33195893(+) A-I      intronic chr19:33184410(+) A-I      intronic chr19:33196674(+) A-I      intronic chr19:33195780(+) A-I      intronic chr19:33195853(+) A-I      intronic chr19:33192163(+) A-I      intronic chr19:33192176(+) A-I      intronic chr19:33192192(+) A-I      intronic chr19:33192809(+) A-I      intronic chr19:33193426(+) A-I      intronic chr19:33193439(+) A-I      intronic chr19:33201679(+) A-I      intronic chr19:33201620(+) A-I      intronic chr19:33193452(+) A-I      intronic chr19:33196117(+) A-I      intronic chr19:33194388(+) A-I      intronic chr19:33194518(+) A-I      intronic chr19:33200650(+) A-I      intronic chr19:33196215(+) A-I      intronic chr19:33186189(+) A-I      intronic chr19:33186296(+) A-I      intronic chr19:33196125(+) A-I      intronic chr19:33196073(+) A-I      intronic chr19:33201391(+) A-I      intronic chr19:33201355(+) A-I      intronic chr19:33201018(+) A-I      intronic chr19:33201017(+) A-I      intronic chr19:33200660(+) A-I      intronic chr19:33200657(+) A-I      intronic chr19:33195857(+) A-I      intronic chr19:33197514(+) A-I      intronic chr19:33195854(+) A-I      intronic chr19:33196752(+) A-I      intronic chr19:33197459(+) A-I      intronic chr19:33196656(+) A-I      intronic chr19:33197342(+) A-I      intronic chr19:33186221(+) A-I      intronic chr19:33204166(+) A-I      3'UTR chr19:33204196(+) A-I      3'UTR chr19:33204086(+) A-I      3'UTR chr19:33204123(+) A-I      3'UTR chr19:33204136(+) A-I      3'UTR chr19:33204160(+) A-I      3'UTR chr19:33195957(+) A-I      intronic chr19:33201057(+) A-I      intronic chr19:33191714(+) A-I      intronic chr19:33191481(+) A-I      intronic chr19:33196126(+) A-I      intronic chr19:33196753(+) A-I      intronic chr19:33196771(+) A-I      intronic chr19:33191620(+) A-I      intronic chr19:33191733(+) A-I      intronic chr19:33192857(+) A-I      intronic chr19:33191766(+) A-I      intronic chr19:33192802(+) A-I      intronic chr19:33191598(+) A-I      intronic chr19:33191807(+) A-I      intronic chr19:33196767(+) A-I      intronic chr19:33192796(+) A-I      intronic chr19:33195751(+) A-I      intronic chr19:33192803(+) A-I      intronic chr19:33196207(+) A-I      intronic chr19:33191438(+) A-I      intronic chr19:33200821(+) A-I      intronic chr19:33196608(+) A-I      intronic chr19:33197478(+) A-I      intronic chr19:33196112(+) A-I      intronic chr19:33195919(+) A-I      intronic chr19:33191839(+) A-I      intronic chr19:33191453(+) A-I      intronic chr19:33196141(+) A-I      intronic chr19:33196691(+) A-I      intronic chr19:33191719(+) A-I      intronic chr19:33203425(+) A-I      3'UTR chr19:33192251(+) A-I      intronic chr19:33195915(+) A-I      intronic chr19:33195860(+) A-I      intronic chr19:33191780(+) A-I      intronic chr19:33196096(+) A-I      intronic chr19:33193509(+) A-I      intronic chr19:33198539(+) A-I      intronic chr19:33191488(+) A-I      intronic chr19:33195914(+) A-I      intronic chr19:33203438(+) A-I      3'UTR chr19:33196169(+) A-I      intronic chr19:33196590(+) A-I      intronic chr19:33191736(+) A-I      intronic chr19:33196109(+) A-I      intronic chr19:33196219(+) A-I      intronic chr19:33192212(+) A-I      intronic chr19:33191465(+) A-I      intronic chr19:33196150(+) A-I      intronic chr19:33196632(+) A-I      intronic chr19:33191848(+) A-I      intronic chr19:33196165(+) A-I      intronic chr19:33196765(+) A-I      intronic chr19:33191887(+) A-I      intronic chr19:33196168(+) A-I      intronic chr19:33204167(+) A-I      3'UTR chr19:33201614(+) A-I      intronic chr19:33195456(+) A-I      intronic chr19:33195788(+) A-I      intronic chr19:33186215(+) A-I      intronic chr19:33191898(+) A-I      intronic chr19:33191687(+) A-I      intronic chr19:33204120(+) A-I      3'UTR chr19:33196601(+) A-I      intronic chr19:33195757(+) A-I      intronic chr19:33194145(+) A-I      intronic chr19:33192875(+) A-I      intronic chr19:33192292(+) A-I      intronic chr19:33196287(+) A-I      intronic chr19:33192229(+) A-I      intronic chr19:33196239(+) A-I      intronic chr19:33196242(+) A-I      intronic chr19:33192186(+) A-I      intronic chr19:33197336(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NUDT19	chr19:33191835(+) A-G intron -    22484847 chr19:33192186(+) A-G intron -    22484847 chr19:33192191(+) A-G intron -    22484847 chr19:33192796(+) A-G intron -    22484847 chr19:33192800(+) A-G intron -    22484847 chr19:33192803(+) A-G intron -    22484847 chr19:33195915(+) A-G intron -    22484847 chr19:33196636(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NUDT19	chr19:33183089-33183090(+) m6A CDS       24209618//24981863//27773536//22575960 chr19:33183199-33183200(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr19:33183298-33183299(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr19:33183386-33183387(+) m6A CDS       24284625//24209618//24981863//22575960 chr19:33200236-33200237(+) m6A CDS       24981863 chr19:33202684-33202685(+) m6A CDS       24284625//24981863//27773535//22608085 chr19:33202719-33202720(+) m6A CDS       24284625//24981863//27773535//22608085 chr19:33202817-33202818(+) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085 chr19:33202834-33202835(+) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085 chr19:33202939-33202940(+) m6A 3'UTR       24981863 chr19:33204385-33204386(+) m6A 3'UTR       27773535 chr19:33204404-33204405(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-26b-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Renal cancer cells     21670082 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Colon adenocarcinoma cells     20864815
	NUDT19	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-26b-5p	Sensorad 99342 Drug sensitive CID 9604911 9604911 Drug resistant 4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive Edatrexate 6917908 Drug sensitive NO Data IN this field 6711510 Drug sensitive Neocuproine 65237 Drug sensitive (2R,3R,4S,5R)-2-(6-Benzylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol 6477178 Drug sensitive Ketone, methyl 2-pyridyl, 4,4-dimethyl-3-thiosemicarbazone 5843399 Drug sensitive Antineoplastic-328785 54607693 Drug sensitive Aspiculamycin hcl 54600418 Drug resistant 4-Cycloheptyl-N-(1-pyridin-2-ylethylideneamino)piperazine-1-carbothioamide 5351332 Drug sensitive Hydroxy AT 125 5351254 Drug sensitive Herbimycin 5311102 Drug sensitive 6-Bromosangivamycin 470030 Drug sensitive N'-(3-Pyridin-2-ylisoquinolin-1-yl)pyridine-2-carboximidamide 463108 Drug sensitive 4-[1-(4-Aminomethyl-phenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamine 44397453 Drug resistant Trichopolyn 431962 Drug sensitive Rogiolol 402519 Drug sensitive 2-Diphenylphosphanylethyl(dipyridin-2-yl)phosphane 400499 Drug sensitive Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive 2-(5-Amino-1-methyl-4,7-dioxoindol-3-yl)-4-methylthiazole 392620 Drug sensitive 1H-Purine, 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)seleno]- 3879067 Drug resistant 4-Phenacyloxychromen-2-one 386272 Drug resistant Stereoisomer of NSC 674066-O 384359 Drug sensitive N-Hydroxy-N-methylpropanethioamide 371713 Drug sensitive Sanguilutine pseudobase 371258 Drug sensitive 3-Nitro-5-formylisoxazole 362479 Drug sensitive Thiosangivamycin 3580213 Drug sensitive Nicomol 34081 Drug sensitive Stannane, trimethyl[(4-morpholinylthioxomethyl)thio]- 300936 Drug sensitive 4,6-Diamino-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile 300567 Drug sensitive 2-Hydroxy-4-((2,4,6-triamino-5-pyrimidinyl)diazenyl)phenylarsonic acid 272658 Drug sensitive Ancitabine hydrochloride 25050 Drug sensitive [(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug sensitive Antibiotic U 29135 24196291 Drug sensitive 7-Fluoro-2-benzoyl-3-trifluoromethylquioxaline 1,4-dioxide 23635154 Drug sensitive 8-Hydroxyquinoline 1923 Drug sensitive Antineoplastic-633273 15954131 Drug sensitive Methyl (7E,9Z,11S,12R,13S,14R,15R,17R,18S,19S,20E)-2,16-diacetyloxy-11,12,14,18,19,31-hexahydroxy-3,7,11,13,17,19,21,27-octamethyl-6,28-dioxo-23,25-dioxa-5-azatetracyclo[20.7.1.14,29.026,30]hentriaconta-1,3,7,9,20,22(30),26,29(31)-octaene-15-carboxylate 138319233 Drug sensitive Inosine dialdehyde 135400916 Drug sensitive Methyl (1S,10R,11S,12S)-11-acetyloxy-12-ethyl-4-[(13R,15R,17R)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 133126830 Drug sensitive 43-Dioxypectenotoxin 131751434 Drug resistant Litmomycin 12310334 Drug sensitive Capri Blue 102162 Drug sensitive 15,16-Dihydrocuracin A 101683509 Drug sensitive (3S,6S)-1,4-Dimethyl-3,6-bis[(2R)-3,3,3-trichloro-2-methylpropyl]piperazine-2,5-dione 101425118 Drug sensitive 4',8-Dinitroflavone 10041189 Drug resistant (1R,6S,11aS,13S,14aR)-1,13-dihydroxy-6-vinyl-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one - Drug resistant 1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant (-)-furodysinin - Drug resistant (Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive 21h,23h-porphine, pyridinium deriv., silver complex - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive antineoplastic-625543 - Drug sensitive antineoplastic-625577 - Drug sensitive antineoplastic-641296 - Drug sensitive antineoplastic-641297 - Drug sensitive antineoplastic-654379 - Drug sensitive ERB-38 Immunotoxin - Drug sensitive leucinostatine d - Drug sensitive n-acetyl-4-s-cystaminyl phenol - Drug sensitive streptorubrin - Drug sensitive viridomycin - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-26b-5p	Formaldehyde 712 Drug interaction    RC00000786 Oxaliplatine 6857599 Drug interaction    RC00000799 Bisphenol A 6623 Drug interaction    RC00000792 Vincristine 5978 Drug interaction    RC00000791 Mitomycin 5746 Drug interaction    RC00000790 Eloxatine 5310940 Drug interaction    RC00000798 Morphine 5288826 Drug interaction    RC00000797 Carboplatinum 38904 Drug interaction    RC00000795 Etoposide 36462 Drug interaction    RC00000794 5-Fluorouracil 3385 Drug interaction    RC00000789 Doxorubicin 31703 Drug interaction    RC00000793 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000788 Celecoxib 2662 Drug interaction    RC00000787 Docetaxel 148124 Drug interaction    RC00000796 Leucovorin 135403648 Drug interaction    RC00000800 Trastuzumab - Drug interaction    RC00000802 Interferon-alpha - Drug interaction    RC00000801 Chemotherapy - Drug interaction    RC00008822

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-26b-5p
Interactor2: NUDT19

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).