Detail Information

Basic Information:


  VIRBase ID:  

HHID00043992

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-26a-5p:           MTPN:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-26a-5p MTPN
miRBase
Accession/Entrez ID		 MIMAT0000082 136319
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - GCDP//V-1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-26a-5p
rs1249227702 chr3:37969424    C/T
rs1348933092 chr3:37969429    T/C
rs756293180 chr3:37969431    G/A
rs1012142515 chr12:57824663    A/C
rs1315291543 chr12:57824671    T/C
rs1445643611 chr12:57824662    T/TA
rs765258989 chr12:57824659    G/A
rs1323067579 chr12:57824677    G/A

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MTPN
chr7:135614483-135614484(-) m6A 3'UTR       24284625
chr7:135614661-135614662(-) m6A 3'UTR       24284625
chr7:135662037-135662038(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536
chr7:135662069-135662070(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-26a-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Neural progenitor cells     21363885
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Human cervical cancer cell line (HeLa)     25760330
Exosome Glioblastoma cells     19011622
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Human esophageal cancer cell line (EC9706)     25184951
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Microvesicle Glioblastoma cells     19011622
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Colon adenocarcinoma cells     20864815
MTPN
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-26a-5p
Crotonoside 65085 Drug sensitive
2,7-Dicyanoxanthone 363841 Drug resistant
Formycin b 135449281 Drug sensitive
(3S,6R,10R,13Z,16S)-10-[(4-Methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[(1S)-1-[(2R,3R)-3-phenyloxiran-2-yl]ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone 101917006 Drug resistant
4',8-Dinitroflavone 10041189 Drug resistant
9-acridinamine, n-(4-ethoxyphenyl)-, monohydrochloride - Drug resistant
7-ethyl-9-methoxy-5-ethoxycamptothecin - Drug resistant
crambescidin 800 trihydrochloride - Drug resistant
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-26a-5p
Curcumin 969516 Drug interaction    RC00000773
Hyaluronidase 91820602 Drug interaction    RC00000778
Formaldehyde 712 Drug interaction    RC00000760
Gemcitabine 60750 Drug interaction    RC00000770
Temozolomide 5394 Drug interaction    RC00000767
Eloxatine 5310940 Drug interaction    RC00000777
Imatinib 5291 Drug interaction    RC00000766
Morphine 5288826 Drug interaction    RC00000776
Cholecalciferol 5280795 Drug interaction    RC00000775
Diethylstilbestrol 448537 Drug interaction    RC00000772
Metformin 4091 Drug interaction    RC00000765
Paclitaxel 36314 Drug interaction    RC00000769
5-Fluorouracil 3385 Drug interaction    RC00000764
Enoxacin 3229 Drug interaction    RC00000763
Doxorubicin 31703 Drug interaction    RC00000768
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000762
Tamoxifen 2733526 Drug interaction    RC00000774
Verapamil 2520 Drug interaction    RC00000761
Docetaxel 148124 Drug interaction    RC00000771
platinum-based doublet chemotherapy - Drug interaction    RC00000780
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00000781
CDF(analogues of curcumin) - Drug interaction    RC00000782
Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00000783
Marine fungal metabolite 1386A - Drug interaction    RC00000784
Trastuzumab - Drug interaction    RC00000785
Interferon-alpha - Drug interaction    RC00000779

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-26a-5p
Interactor2: MTPN

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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