Detail Information

Basic Information:


  VIRBase ID:  

HHID00043686

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-24-3p:           PAQR3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-24-3p PAQR3
miRBase
Accession/Entrez ID		 MIMAT0000080 152559
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - RKTG

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-24-3p
rs1175827694 chr19:13836288    CCT/C
rs1296736495 chr19:13836310    A/G
rs1401187484 chr19:13836295    C/T
rs768693029 chr9:95086069    C/T
rs1449243881 chr19:13836308    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PAQR3
chr4:79839157(-) A-I      3'UTR
chr4:79839152(-) A-I      3'UTR
chr4:79839151(-) A-I      3'UTR
chr4:79839144(-) A-I      3'UTR
chr4:79839143(-) A-I      3'UTR
chr4:79839194(-) A-I      3'UTR
chr4:79839198(-) A-I      3'UTR
chr4:79839158(-) A-I      3'UTR
chr4:79839131(-) A-I      3'UTR
chr4:79814994(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PAQR3
chr4:79832156-79832157(-) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085
chr4:79832263-79832264(-) m6A 3'UTR//intron       24284625//24209618//24981863//22608085
chr4:79832282-79832283(-) m6A 3'UTR//intron       24284625//24209618//24981863//22608085
chr4:79832353-79832354(-) m6A 3'UTR//intron       24284625//24981863//22608085
chr4:79832635-79832636(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085
chr4:79832668-79832669(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085
chr4:79832873-79832874(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr4:79832993-79832994(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr4:79833121-79833122(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr4:79833130-79833131(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr4:79833220-79833221(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085
chr4:79833240-79833241(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085
chr4:79860422-79860423(-) m6A 5'UTR       24209618//27371828//27773536
chr4:79860492-79860493(-) m6A 5'UTR       24209618//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-24-3p
Apoptotic body Human umbilical vein endothelial cells     19996457
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Sera     24978137
Exosome Pooled sera     27278097
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Ovarian follicular fluid     22116803
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Blood|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Seminal fluid|Tongue tissue     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Hepatoma cells     23771658
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Myotube     27396686
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
PAQR3
Chromatin K562 cells     -
Cytosol K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-24-3p
2-(2,4-Difluorophenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione 9905583 Drug resistant
3-Piperidino-2-phenylpropiophenone 89341 Drug resistant
Acid Green 27 80837 Drug resistant
Arjunolic acid 73641 Drug resistant
Phosphotrienin 6913994 Drug resistant
Adenosine, 2-bromo-2'-deoxy- 55914 Drug resistant
3-Deazauridine 54684286 Drug resistant
Heliangolide 5384466 Drug resistant
Ovatifolin acetate 5358419 Drug resistant
Crassin, acetate 5355441 Drug resistant
1,4-Benzoquinone 4650 Drug resistant
10-Hydroxy-5-methoxy-1-(2-methyloxiran-2-yl)-1,2-dihydrofuro[2,3-c]xanthen-6-one 429905 Drug resistant
Mechlorethamine 4033 Drug resistant
2,5-Bis(aziridin-1-yl)-3-(hydroxymethyl)-6-methylcyclohexa-2,5-diene-1,4-dione 394347 Drug resistant
Antineoplastic-690271 391308 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug resistant
4-Nitro-6-(trifluoromethyl)-2,1,3-benzoselenadiazole 362897 Drug resistant
2-Isopropenyl-4,6-diphenoxy-1,3,5-triazine 340916 Drug resistant
Pyrazoloacridine 339455 Drug resistant
4-Ethyl-6-methoxy-7-(oxiran-2-ylmethoxy)quinazoline 333565 Drug resistant
Dmask 32465 Drug resistant
Tartrolon b 23685389 Drug sensitive
2,4,6-Trichloro-5-methylpyrimidine 232789 Drug resistant
4-Chloro-5-phenoxy-3H-1,2-dithiole-3-thione 16766044 Drug resistant
Arypurine derivatives 16220246 Drug resistant
Jolkinolide B 161954 Drug resistant
Methyl ester prodigiosene 136040158 Drug resistant
6-[4-(1-Cyclohexenyl)-1,3-butadiyn-1-yl]-2(2H)-pyranone 10263039 Drug resistant
Erigerol 101318126 Drug resistant
4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug resistant
4-quinazolone, 7-amino-3-(4-methoxyphenyl)-, hydrate - Drug resistant
9,10-anthracenedione, 1-[(oxiranylmethyl)amino]- - Drug resistant
acetamide, n-(2-mercaptoethyl)-, benzoate (6ci, 7ci) - Drug resistant
b676297k277 3',4'-deoxypsorospermin 3',4'-chlorohydrin - Drug resistant
ethyl, methoxy, prodigisine - Drug resistant
phenol, 4,4'-(5,5'-biisoxazole-3,3'-diyl)bis- - Drug resistant
propan-1-one, 2,3-dichloro-1,3-bis(4-methylphenyl)- - Drug resistant
pyrimidine, 2,4,5-trichloro-6-ethyl- - Drug resistant
pyrimidine, 2,4,5-trichloro-6-isopropyl- - Drug resistant
Tetraplatin - Drug resistant
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-24-3p
Curcumin 969516 Drug interaction    RC00000723
Formaldehyde 712 Drug interaction    RC00000709
Ethanol 702 Drug interaction    RC00000708
Irinotecan 60838 Drug interaction    RC00000718
Gemcitabine 60750 Drug interaction    RC00000717
Topotecan 60700 Drug interaction    RC00000716
Floxuridine 5790 Drug interaction    RC00000713
Temozolomide 5394 Drug interaction    RC00000712
Eloxatine 5310940 Drug interaction    RC00000727
Morphine 5288826 Drug interaction    RC00000726
Cyclosporin A 5284373 Drug interaction    RC00000725
Decitabine 451668 Drug interaction    RC00000722
Trichostatin A 444732 Drug interaction    RC00000721
Etoposide 36462 Drug interaction    RC00000715
5-Fluorouracil 3385 Drug interaction    RC00000711
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000710
Tamoxifen 2733526 Drug interaction    RC00000724
Arsenic trioxide 14888 Drug interaction    RC00000714
Docetaxel 148124 Drug interaction    RC00000720
Methotrexate 126941 Drug interaction    RC00000719
platinum-based doublet chemotherapy - Drug interaction    RC00000728
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00000729
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00000730
Bio-Oss - Drug interaction    RC00000731
Olea europaea leaf extract - Drug interaction    RC00000732
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-24-3p
5-Fluorouracil 3385       27513190

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-24-3p
Interactor2: PAQR3

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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