Basic Information:

  VIRBase ID:  

HHID00041822

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-17-3p:  MIMAT0000071          USP14:  NM_005151     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-17-3p	USP14
miRBase Accession/Entrez ID	MIMAT0000071	9097
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	TGT

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-17-3p	rs1223935699 chr13:91350673    G/C rs748812871 chr13:91350670    C/CTT rs762895935 chr13:91350674    T/A rs762895935 chr13:91350674    T/C rs775361397 chr13:91350666    G/T rs780824699 chr13:91350659    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	USP14	chr18:207520(+) A-I      intronic chr18:207521(+) A-I      intronic chr18:207503(+) A-I      intronic chr18:208846(+) A-I      intronic chr18:204924(+) A-I      intronic chr18:207483(+) A-I      intronic chr18:208845(+) A-I      intronic chr18:170094(+) A-I      intronic chr18:170099(+) A-I      intronic chr18:170100(+) A-I      intronic chr18:170105(+) A-I      intronic chr18:170123(+) A-I      intronic chr18:207480(+) A-I      intronic chr18:206807(+) A-I      intronic chr18:206739(+) A-I      intronic chr18:206738(+) A-I      intronic chr18:170124(+) A-I      intronic chr18:207493(+) A-I      intronic chr18:170125(+) A-I      intronic chr18:205628(+) A-I      intronic chr18:167605(+) A-I      intronic chr18:160478(+) A-I      intronic chr18:167606(+) A-I      intronic chr18:168002(+) A-I      intronic chr18:168037(+) A-I      intronic chr18:168081(+) A-I      intronic chr18:168109(+) A-I      intronic chr18:168160(+) A-I      intronic chr18:168578(+) A-I      intronic chr18:168584(+) A-I      intronic chr18:168946(+) A-I      intronic chr18:168997(+) A-I      intronic chr18:172136(+) A-I      intronic chr18:174915(+) A-I      intronic chr18:184688(+) A-I      intronic chr18:185300(+) A-I      intronic chr18:185429(+) A-I      intronic chr18:185839(+) A-I      intronic chr18:186302(+) A-I      intronic chr18:186314(+) A-I      intronic chr18:186577(+) A-I      intronic chr18:186597(+) A-I      intronic chr18:207572(+) A-I      intronic chr18:207523(+) A-I      intronic chr18:206881(+) A-I      intronic chr18:206813(+) A-I      intronic chr18:206781(+) A-I      intronic chr18:206778(+) A-I      intronic chr18:205622(+) A-I      intronic chr18:205765(+) A-I      intronic chr18:186594(+) A-I      intronic chr18:205629(+) A-I      intronic chr18:186712(+) A-I      intronic chr18:186709(+) A-I      intronic chr18:186684(+) A-I      intronic chr18:186638(+) A-I      intronic chr18:186606(+) A-I      intronic chr18:186602(+) A-I      intronic chr18:205677(+) A-I      intronic chr18:167609(+) A-I      intronic chr18:167698(+) A-I      intronic chr18:167960(+) A-I      intronic chr18:167986(+) A-I      intronic chr18:205554(+) A-I      intronic chr18:207594(+) A-I      intronic chr18:205000(+) A-I      intronic chr18:168087(+) A-I      intronic chr18:186591(+) A-I      intronic chr18:168601(+) A-I      intronic chr18:205524(+) A-I      intronic chr18:205620(+) A-I      intronic chr18:186503(+) A-I      intronic chr18:160256(+) A-I      intronic chr18:208849(+) A-I      intronic chr18:160288(+) A-I      intronic chr18:205090(+) A-I      intronic chr18:168635(+) A-I      intronic chr18:205621(+) A-I      intronic chr18:168919(+) A-I      intronic chr18:168036(+) A-I      intronic chr18:204976(+) A-I      intronic chr18:184747(+) A-I      intronic chr18:205519(+) A-I      intronic chr18:205587(+) A-I      intronic chr18:207580(+) A-I      intronic chr18:168930(+) A-I      intronic chr18:167232(+) A-I      intronic chr18:194810(+) A-I      intronic chr18:161148(+) A-I      intronic chr18:185967(+) A-I      intronic chr18:160394(+) A-I      intronic chr18:205624(+) A-I      intronic chr18:161028(+) A-I      intronic chr18:178100(+) A-I      intronic chr18:206744(+) A-I      intronic chr18:172111(+) A-I      intronic chr18:194675(+) A-I      intronic chr18:178071(+) A-I      intronic chr18:206822(+) A-I      intronic chr18:167128(+) A-I      intronic chr18:168886(+) A-I      intronic chr18:205619(+) A-I      intronic chr18:204975(+) A-I      intronic chr18:185407(+) A-I      intronic chr18:178234(+) A-I      intronic chr18:206704(+) A-I      intronic chr18:185963(+) A-I      intronic chr18:184498(+) A-I      intronic chr18:205660(+) A-I      intronic chr18:196240(+) A-I      intronic chr18:168600(+) A-I      intronic chr18:184649(+) A-I      intronic chr18:205004(+) A-I      intronic chr18:172057(+) A-I      intronic chr18:160928(+) A-I      intronic chr18:212516(+) A-I      3'UTR chr18:185325(+) A-I      intronic chr18:186349(+) A-I      intronic chr18:205654(+) A-I      intronic chr18:196333(+) A-I      intronic chr18:185954(+) A-I      intronic chr18:184525(+) A-I      intronic chr18:204987(+) A-I      intronic chr18:205059(+) A-I      intronic chr18:185339(+) A-I      intronic chr18:205559(+) A-I      intronic chr18:207536(+) A-I      intronic chr18:185276(+) A-I      intronic chr18:185262(+) A-I      intronic chr18:205588(+) A-I      intronic chr18:168894(+) A-I      intronic chr18:185360(+) A-I      intronic chr18:167102(+) A-I      intronic chr18:208929(+) A-I      intronic chr18:185229(+) A-I      intronic chr18:168065(+) A-I      intronic chr18:168454(+) A-I      intronic chr18:172059(+) A-I      intronic chr18:205169(+) A-I      intronic chr18:160254(+) A-I      intronic chr18:168574(+) A-I      intronic chr18:205713(+) A-I      intronic chr18:196193(+) A-I      intronic chr18:205630(+) A-I      intronic chr18:205518(+) A-I      intronic chr18:168956(+) A-I      intronic chr18:167645(+) A-I      intronic chr18:160438(+) A-I      intronic chr18:196204(+) A-I      intronic chr18:172187(+) A-I      intronic chr18:161111(+) A-I      intronic chr18:205036(+) A-I      intronic chr18:189672(+) A-I      intronic chr18:186352(+) A-I      intronic chr18:161108(+) A-I      intronic chr18:184499(+) A-I      intronic chr18:205098(+) A-I      intronic chr18:205545(+) A-I      intronic chr18:208887(+) A-I      intronic chr18:172177(+) A-I      intronic chr18:208803(+) A-I      intronic chr18:186345(+) A-I      intronic chr18:160127(+) A-I      intronic chr18:169127(+) A-I      intronic chr18:167129(+) A-I      intronic chr18:178203(+) A-I      intronic chr18:196426(+) A-I      intronic chr18:178090(+) A-I      intronic chr18:186497(+) A-I      intronic chr18:185191(+) A-I      intronic chr18:186674(+) A-I      intronic chr18:205714(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	USP14	chr18:204975(+) A-I intron -    15258596 chr18:204987(+) A-I intron -    15258596 chr18:205000(+) A-I intron -    15258596 chr18:205001(+) A-I intron -    15258596 chr18:205014(+) A-I intron -    15258596 chr18:205016(+) A-I intron -    15258596 chr18:205030(+) A-I intron -    15258596 chr18:205036(+) A-I intron -    15258596 chr18:205050(+) A-I intron -    15258596 chr18:205059(+) A-I intron -    15258596 chr18:205660(+) A-I intron -    22327324 chr18:168454(+) A-G intron -    22484847 chr18:205630(+) A-G intron -    22484847 chr18:205660(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	USP14	chr18:158563-158564(+) m6A 5'UTR//exon       24209618//25456834//24981863 chr18:163362-163363(+) m6A 5'UTR//CDS//exon       24209618//24981863 chr18:163419-163420(+) m6A CDS//exon       24981863 chr18:166802-166803(+) m6A CDS//exon//intron       24981863 chr18:178928-178929(+) m6A CDS//intron       24981863 chr18:204598-204599(+) m6A CDS//exon       27773535 chr18:204613-204614(+) m6A CDS//exon       27773535 chr18:210011-210012(+) m6A CDS//exon       27773535 chr18:210488-210489(+) m6A CDS//exon       27773535//22575960 chr18:211210-211211(+) m6A CDS//exon       27773535//22575960 chr18:211366-211367(+) m6A 3'UTR//exon       24981863//22608085 chr18:211401-211402(+) m6A 3'UTR//exon       24981863//22608085 chr18:211411-211412(+) m6A 3'UTR//exon       24981863//22608085 chr18:211421-211422(+) m6A 3'UTR//exon       24981863//22608085 chr18:211506-211507(+) m6A 3'UTR//exon       24981863//26404942//22608085 chr18:211667-211668(+) Y 3'UTR//exon       25219674 chr18:212014-212015(+) m6A 3'UTR//exon       27773535 chr18:214458-214459(+) m6A 3'UTR       27773535 chr18:214549-214550(+) m6A 3'UTR       27773535 chr18:214557-214558(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-17-3p	Exosome Plasma     19289371 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Liver resident stem cells     20668554 Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	USP14	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-17-3p	Formaldehyde 712 Drug interaction    RC00000431 Vorinostat 5311 Drug interaction    RC00000432

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-17-3p	5-Fluorouracil 3385       25356050

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-17-3p
Interactor2: USP14

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.