Detail Information

Basic Information:


  VIRBase ID:  

HHID00039149

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7b-5p:           ADRB2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-let-7b-5p ADRB2
miRBase
Accession/Entrez ID		 MIMAT0000063 154
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ADRB2R//ADRBR//B2AR//BAR//BETA2AR

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-let-7b-5p
rs1209727973 chr22:46113709    G/A
rs1363782548 chr22:46113707    G/A

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ADRB2
chr5:148206691-148206692(+) m6A CDS       24284625//24981863//22608085
chr5:148206721-148206722(+) m6A CDS       24284625//24981863//22608085
chr5:148206760-148206761(+) m6A CDS       24284625//24981863//22608085
chr5:148206958-148206959(+) m6A CDS       24284625//22608085
chr5:148206980-148206981(+) m6A CDS       24284625//22608085
chr5:148207124-148207125(+) m6A CDS       24284625//25456834//24981863//22608085
chr5:148207164-148207165(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr5:148207500-148207501(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207518-148207519(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207532-148207533(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207550-148207551(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207658-148207659(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr5:148207676-148207677(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148207683-148207684(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148207710-148207711(+) m6A 3'UTR       24981863//22608085
chr5:148208019-148208020(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148208043-148208044(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148208058-148208059(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148208064-148208065(+) m6A 3'UTR       24284625//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-let-7b-5p
Apoptotic body Human umbilical vein endothelial cells     19996457
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm HeLa cells     22058130
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Healthy donor seminal fluid|Ovarian carcinoma cells (2008 cell line)     25267620
Exosome Pooled sera     27278097
Exosome Saliva     19627513
Exosome Hetastatic gastric cancer cell line (AZ-P7a)     20949044
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells     21505438
Exosome Renal cancer cells     21670082
Exosome Epidermal melanocytes (HEMa-LP)     23056502
Exosome Saliva     23302638
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Urine     25135963
Exosome Human esophageal cancer cell line (EC9706)     25184951
Exosome Blood|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Mast cells|Saliva|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Glioma cell line (U251)     23807490
Microvesicle Plasma     19002258
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Hepatoma cells     23771658
Microvesicle Blood|Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion HEK-293 cells|HeLa cells|Myotube     27396686
Mitochondrion HEK-293 cells|HeLa cells|Skeletal muscle cells     27563705
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Colon adenocarcinoma cells     20864815
Nucleus HeLa cells     22058130
ADRB2
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-let-7b-5p
Iodine Green 9956454 Drug resistant
Kahalalide F 9898671 Drug sensitive
Actinomycin X4357G methoxime 9573583 Drug resistant
Dichlorodipropylstannane 93562 Drug resistant
Ambrosin 92119 Drug resistant
Terreic acid 91437 Drug resistant
[(1R,2Z,4R,8R,9R,11R,12S)-1,12-Dihydroxy-2-(hydroxymethyl)-11-methyl-7-methylidene-6-oxo-5,14-dioxatricyclo[9.2.1.04,8]tetradec-2-en-9-yl] (Z)-2-methylbut-2-enoate 90475906 Drug resistant
[(1R,2S,6R,7R,9S,12S,13S)-13-(Acetyloxymethyl)-12-hydroxy-9-methyl-5-methylidene-4-oxo-3,14-dioxatricyclo[7.4.1.02,6]tetradecan-7-yl] (Z)-2-(acetyloxymethyl)but-2-enoate 90473692 Drug resistant
3-Piperidino-2-phenylpropiophenone 89341 Drug resistant
Acid Green 27 80837 Drug resistant
4,7-Diphenyl-1,10-phenanthroline 72812 Drug resistant
Piperidinium pentamethylenedithiocarbamate 72508 Drug resistant
2-Butenoic acid, 2-methyl-, 2,3,3a,4,5,8,9,11a-octahydro-8-hydroxy-6-(hydroxymethyl)-10-methyl-3-methylene-2-oxocyclodeca(b)furan-4-yl ester, (3aR-(3aR*,4R*(Z),6Z,8S*,10E,11aR*))- 71586750 Drug resistant
1,3,5-Triacryloylhexahydro-1,3,5-triazine 70397 Drug resistant
Laurolinium acetate 67354 Drug resistant
Acnistin F 6712173 Drug resistant
4'-Chloro-3-hydroxy-2'-methyl-2-naphthanilide 66718 Drug resistant
Reactive Blue 2 656725 Drug resistant
Jatrophon 6325446 Drug resistant
Piriqualone 6015423 Drug resistant
[(2Z)-12-Hydroxy-2,11-dimethyl-7-methylidene-6-oxo-5,14-dioxatricyclo[9.2.1.04,8]tetradec-2-en-9-yl] (E)-2-methylbut-2-enoate 5477565 Drug resistant
Caracemide 54747 Drug resistant
(Z)-4-Bromo-4-iodo-3-phenylbut-3-en-2-one 5467656 Drug resistant
Incomptina B 54612584 Drug resistant
Varacin trifluoroacetate salt 54611558 Drug resistant
9-alpha-Acetoxyparthenolide 54611286 Drug resistant
Selendale 54601159 Drug sensitive
(1S,2R,4R,7E,9R)-9-Hydroxy-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one 54600951 Drug resistant
Stereoisomer of 672120 (MW=262) 5459262 Drug resistant
Trunculin A 5459125 Drug resistant
Heliangolide 5384466 Drug resistant
Ovatifolin acetate 5358419 Drug resistant
Crassin, acetate 5355441 Drug resistant
Dihydro-5-azacytidine 5351280 Drug resistant
Cyclosporin A 5284373 Drug resistant
Plumericin 5281545 Drug resistant
Eupachlorin 5281446 Drug resistant
2-Hydroxy-2-phenyl-3-(p-tolylsulfanyl)butanamide 495813 Drug resistant
Patulin 4696 Drug resistant
Fastigilin B 442241 Drug resistant
Elephantopin 442206 Drug resistant
Elephantin 442205 Drug resistant
Oridonin (thiol adduct OF) 432952 Drug resistant
10-Hydroxy-5-methoxy-1-(2-methyloxiran-2-yl)-1,2-dihydrofuro[2,3-c]xanthen-6-one 429905 Drug resistant
S-(Diethylarsino)-3-mercapto-1,2-propanediol 406476 Drug resistant
Mechlorethamine 4033 Drug resistant
Artelastin 399488 Drug resistant
2,5-Bis(aziridin-1-yl)-3-(hydroxymethyl)-6-methylcyclohexa-2,5-diene-1,4-dione 394347 Drug resistant
5,8-Quinolinedione, 2-methyl- 388305 Drug resistant
Adaphostin 387042 Drug resistant
4-Azido-2-chloro-3-cyanoquinoline 381915 Drug resistant
N,N-Bis(2-chloropropyl)-N-methylammonium chloride 381678 Drug resistant
2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant
1H-Benz[g]indol-5-ol, 2-phenyl 371327 Drug resistant
Tetrakis(8-chinolineolato)titanium(IV)-tetrahydrochloride 368279 Drug resistant
Benzoxazole, 2-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]- 364608 Drug resistant
4-Nitro-6-(trifluoromethyl)-2,1,3-benzoselenadiazole 362897 Drug resistant
Discorhabdin C-nitrodienone . TFA 362394 Drug resistant
Discorhabdin C . TFA 362393 Drug resistant
5-(4-Azido-3-chlorophenyl)-6-ethylpyrimidine-2,4-diamine 353605 Drug resistant
2-Isopropenyl-4,6-diphenoxy-1,3,5-triazine 340916 Drug resistant
4-Ethyl-6-methoxy-7-(oxiran-2-ylmethoxy)quinazoline 333565 Drug resistant
Helenin 327378 Drug resistant
Dmask 32465 Drug resistant
2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug resistant
Benzofurazan, 4-[(3-methoxyphenyl)thio]-7-nitro-, 3-oxide 313591 Drug resistant
1,4-Naphthalenedione, 5,8-dihydroxy-2,3-bis(hydroxymethyl)- 313371 Drug resistant
Stannane, trimethyl[(4-morpholinylthioxomethyl)thio]- 300936 Drug resistant
[(5Z)-1,7,7-Trimethyl-5-(nitromethylene)-6-oxo-norbornan-2-yl] acetate 3004516 Drug resistant
Quinoxaline, 6-chloro-2,3-bis(iodomethyl)- 286252 Drug resistant
2-Chloro-5-[4-[2-chloro-4-(4,6-diamino-2,2-dimethyl-1,3,5-triazin-1-yl)phenyl]butyl]benzenesulfonyl fluoride;ethanesulfonic acid 278692 Drug resistant
Dichloroallyl lawsone 277767 Drug resistant
3,6-Dibromophenanthrene-9,10-dione 258450 Drug resistant
(1S,2R,5Z,10R,11S,12R,16S)-2-Hydroxy-2,6,10-trimethyl-15-methylidene-13,18-dioxatricyclo[9.6.1.012,16]octadec-5-en-14-one 23425613 Drug resistant
2,4,6-Trichloro-5-methylpyrimidine 232789 Drug resistant
Scillirosidin, glycoside 222160 Drug resistant
Diethylcarbamodithioic acid, sodium salt 21192315 Drug resistant
(1S,3R,7Z,9R,12S,13R,15R)-13-Hydroxy-3,7,12-trimethyl-13-prop-1-en-2-yl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 20835084 Drug resistant
Methyl 1,6,8,14a-tetrahydroxy-11-[(4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl)amino]-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-5,6-dihydrobenzo[a]tetracene-2-carboxylate 197261 Drug resistant
8-Hydroxyquinoline 1923 Drug resistant
5-Nitroso-8-hydroxyquinoline 19103 Drug resistant
4-Chloro-5-phenoxy-3H-1,2-dithiole-3-thione 16766044 Drug resistant
Arypurine derivatives 16220246 Drug resistant
(6R,7R,9R,14As,15R)-7-cyano-4-hydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-9-((2-oxopropanamido)methyl)-6,7,9,10,13,14,14a,15-octahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinolin-1-yl 2-hydroxyacetate 154731670 Drug resistant
(2Z,9E,13Z,15E)-4',11-Dihydroxy-2,4',9-trimethylspiro[3-aza-1(2,4)-thiazolacyclohexadecaphanene-6,3'-[1,2]dithiolane]-9,13,15-triene-4,5',12-trione 2'-oxide 154730760 Drug resistant
[(1R,2R,4R,6E,9R,10S)-2,7-Dimethyl-5,8,14-trioxo-10-prop-1-en-2-yl-15-oxatricyclo[11.2.1.02,4]hexadeca-6,13(16)-dien-9-yl] acetate 15384977 Drug resistant
[(1S,2R,3R,4R,6S,8S,9R,10S,11S,13R)-2,8-Diacetyloxy-3,6-dihydroxy-5,5,9-trimethyl-14-methylidene-15-oxo-11-tetracyclo[11.2.1.01,10.04,9]hexadecanyl] acetate 153274253 Drug resistant
Bis(triethylphosphine)gold(I) chloride 149280 Drug resistant
Dibromsalan 14839 Drug resistant
N-[3-[(3-Amino-3-oxoprop-1-en-2-yl)amino]-3-oxoprop-1-en-2-yl]-2-[(1S)-18-[(2S)-2,3-dihydroxybutan-2-yl]-11-ethylidene-59-hydroxy-8,31-bis(1-hydroxyethyl)-26,46-dimethyl-40,43-dimethylidene-6,9,16,23,28,38,41,44,47-nonaoxo-37-propan-2-yl-27-oxa-3,13,20,56-tetrathia-7,10,17,24,36,39,42,45,48,52,58,61,62,63,64-pentadecazanonacyclo[23.23.9.329,35.12,5.112,15.119,22.154,57.01,53.032,60]tetrahexaconta-2(64),4,12(63),19(62),21,29(61),30,32(60),33,51,54,57-dodecaen-51-yl]-1,3-thiazole-4-carboxamide 146156820 Drug resistant
N-Cyano-N'-methacryloylguanidine 135429904 Drug resistant
(1R,2S,5S,8S,9S,17R,18R,21S,24R,26S,27S)-14-Chloro-5,15-dihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacos-11-ene-4,10,22,29-tetrone 134715214 Drug resistant
(1S,3R,7Z,9R,12S,13R,15S)-13-Butan-2-yl-13-hydroxy-3,7,12-trimethyl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 11972510 Drug resistant
Melampodinin 11953936 Drug resistant
6-(Hydroxymethyl)-1,4-anthracenedione 11402158 Drug resistant
p-Toluquinone 11122 Drug resistant
Marcellomycin 107861 Drug resistant
15,16-Dihydrocuracin A 101683509 Drug resistant
(1S,2R,4R,6S,11R,12S,15R,18S,19R,20R,21S,23R,26R)-15-Hydroxy-11,18,21-trimethyl-5,17,24,28,29-pentaoxanonacyclo[17.9.1.11,20.02,12.04,6.06,11.015,19.018,23.021,26]triacont-8-ene-10,16,25,30-tetrone 101528280 Drug resistant
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug resistant
[(1S,2S,4Z,8Z,12R,13S)-12-Hydroxy-4,8,12-trimethyl-16-methylidene-15-oxo-14-oxabicyclo[11.3.1]heptadeca-4,8-dien-2-yl] acetate 100921072 Drug resistant
Cyanocycline A 100158 Drug resistant
(1s,2e,4r,6r,7e,10r,11e)-2,7,11-cembratriene-4,6,10-triol - Drug resistant
(2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug resistant
1,3-butadiene, 1,1,2,4,4-pentachloro-3-nitro- - Drug resistant
1h-1,2,4-triazole, 3-(4-diazo-4h-imidazol-5-yl)- - Drug resistant
1h-benzo[a]carbazole-1,4(11h)-dione, 11-phenyl- - Drug resistant
2-acetyl-9-methoxy-1,2-dihydroellipticine - Drug resistant
2-bromo-5,8-dihydroxy-3-methyl-1,4-naphthoquinone - Drug resistant
2-propen-1-one, 3-(2-hydroxyphenyl)-1-phenyl- (9ci) - Drug resistant
4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug resistant
4(3h)-quinazolinone, 2,2'-thiobis[3-amino- - Drug resistant
4-quinazolone, 7-amino-3-(4-methoxyphenyl)-, hydrate - Drug resistant
4-thiomorpholinecarbodithioic acid, antimony complex - Drug resistant
9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug resistant
acetamide, n-(2-mercaptoethyl)-, benzoate (6ci, 7ci) - Drug resistant
cyclopentanone, 2,5-bis[(trimethylamino)methyl]-, iodide - Drug resistant
n,n'-bis(oxydiethylene)thiocarbamoylsulfenamide - Drug resistant
phosphonium, (3-bromopropyl)triphenyl- bromide - Drug resistant
propan-1-one, 2,3-dichloro-1,3-bis(4-methylphenyl)- - Drug resistant
pyrimidine, 2,4,5-trichloro-6-isopropyl- - Drug resistant
actinomycin pip t.beta. - Drug resistant
bisacetylacetone ethylenediimine tin - Drug resistant
Copper(II) complex with quin as a ligand - Drug resistant
Methotrexate Derivative - Drug resistant
michicarcin - Drug resistant
n-acetyl-4-s-cystaminyl phenol - Drug resistant
recombinant protein 1815 (plate 31 h4) - Drug resistant
thiadiazines - Drug resistant
pyrazino[1,2-a]benzimidazole, 1,3-diphenyl- - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-let-7b-5p
Hyaluronidase 91820602 Drug interaction    RC00000224
Formaldehyde 712 Drug interaction    RC00000207
Gemcitabine 60750 Drug interaction    RC00000219
Estradiol 5757 Drug interaction    RC00000213
Eloxatine 5310940 Drug interaction    RC00000222
Imatinib 5291 Drug interaction    RC00000212
Paroxetine 43815 Drug interaction    RC00000218
Epirubicin 41867 Drug interaction    RC00000217
Metformin 4091 Drug interaction    RC00000211
Etoposide 36462 Drug interaction    RC00000216
Paclitaxel 36314 Drug interaction    RC00000215
5-Fluorouracil 3385 Drug interaction    RC00000210
Enoxacin 3229 Drug interaction    RC00000209
Doxorubicin 31703 Drug interaction    RC00000214
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000208
Tamoxifen 2733526 Drug interaction    RC00000221
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00000223
Nandrolone phenpropionate 229455 Drug interaction    RC00000220
platinum-based doublet chemotherapy - Drug interaction    RC00000225
CDF(analogues of curcumin) - Drug interaction    RC00000226
Marine fungal metabolite 1386A - Drug interaction    RC00000227
Medpor - Drug interaction    RC00000228
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-let-7b-5p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-let-7b-5p
Interactor2: ADRB2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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