Basic Information:

  VIRBase ID:  

HHID00038687

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      MALAT1:  NR_144568          hsa-miR-185-5p:  MIMAT0000455     

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Interactor Information:

	Interactor1	Interactor2
Symbol	MALAT1	hsa-miR-185-5p
miRBase Accession/Entrez ID	378938	MIMAT0000455
Organism	Homo sapiens	Homo sapiens
Category	lncRNA	miRNA
Alias	HCN//LINC00047//NCRNA00047//NEAT2//PRO2853	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-185-5p	rs1249170072 chr22:20033164    G/A rs770235403 chr22:20033168    T/C rs775856637 chr22:20033173    G/A rs1398989482 chr22:20033154    G/A rs761385932 chr22:20033159    GAA/G

RNA Editing:

Resource	Symbol	Editing Position
Lncediting	MALAT1	chr11: 65273328     chr11: 65273630     chr11: 65269316

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MALAT1	chr11:65273328(+) A-I      ncRNA chr11:65269316(+) A-I      ncRNA chr11:65273630(+) A-I      ncRNA

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MALAT1	chr11:65268358(+) A-I intron -    22327324 chr11:65268662(+) A-I intron -    22327324 chr11:65268829(+) A-I intron -    22327324 chr11:65268863(+) A-I intron -    22327324 chr11:65269100(+) A-I intron -    22327324 chr11:65269102(+) A-I intron -    22327324 chr11:65269316(+) A-I intron -    22327324 chr11:65269321(+) A-I intron -    22327324 chr11:65269667(+) A-I intron -    22327324 chr11:65270102(+) A-I intron -    22327324 chr11:65270147(+) A-I intron -    22327324 chr11:65270472(+) A-I intron -    22327324 chr11:65271236(+) A-I intron -    22327324 chr11:65271256(+) A-I intron -    22327324 chr11:65271381(+) A-I intron -    22327324 chr11:65271563(+) A-I intron -    22327324 chr11:65271566(+) A-I intron -    22327324 chr11:65272270(+) A-I intron -    22327324 chr11:65272294(+) A-I intron -    22327324 chr11:65272297(+) A-I intron -    22327324 chr11:65272325(+) A-I intron -    22327324 chr11:65272340(+) A-I intron -    22327324 chr11:65272589(+) A-I intron -    22327324 chr11:65272859(+) A-I intron -    22327324 chr11:65273033(+) A-I intron -    22327324 chr11:65273037(+) A-I intron -    22327324 chr11:65273038(+) A-I intron -    22327324 chr11:65273039(+) A-I intron -    22327324 chr11:65273041(+) A-I intron -    22327324 chr11:65273068(+) A-I intron -    22327324 chr11:65273328(+) A-I intron -    22327324 chr11:65273630(+) A-T intron -    21725310   //22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MALAT1	chr11:65266574-65266575(+) m6A exon       24209618//24981863//26404942//27773535//22575960//22608085 chr11:65266719-65266720(+) m6A exon       24209618//24981863//27773535//22575960//22608085 chr11:65266765-65266766(+) m6A exon       24981863//27773535//22575960//22608085 chr11:65266836-65266837(+) m6A exon//intron       24981863//27773535//22575960//22608085 chr11:65266903-65266904(+) m6A exon//intron       24981863//27773535//22575960//22608085 chr11:65266976-65266977(+) m6A exon//intron       24981863//27773535//22575960//22608085 chr11:65266994-65266995(+) m6A exon//intron       24981863//27773535//22575960//22608085 chr11:65267101-65267102(+) m6A exon//intron       24981863//28052920//27773535//22575960//22608085 chr11:65267135-65267136(+) m6A exon//intron       24981863//28052920//27773535//22575960//22608085 chr11:65267143-65267144(+) m6A exon//intron       24981863//28052920//27773535//22575960//22608085 chr11:65267147-65267148(+) Am exon//intron       - chr11:65267202-65267203(+) m6A exon//intron       24981863//28052920//27773535//22575960//22608085 chr11:65267234-65267235(+) m6A exon//intron       24981863//28052920//27773535//22575960//22608085 chr11:65267264-65267265(+) m6A exon//intron       24981863//28052920//27773535//22575960//22608085 chr11:65267276-65267277(+) m6A exon//intron       24981863//28052920//27773535//22575960//22608085 chr11:65267303-65267304(+) m6A exon//intron       24981863//28052920//27773535//22575960//22608085 chr11:65267329-65267330(+) m6A exon//intron       24981863//28052920//26404942//27773535//22575960//22608085 chr11:65267380-65267381(+) m6A exon//intron       24981863//26404942//27773535//22575960//22608085 chr11:65267390-65267391(+) m6A exon//intron       24981863//26404942//27773535//22575960//22608085 chr11:65267567-65267568(+) m6A exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr11:65267573-65267574(+) m6A exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr11:65267645-65267646(+) m6A exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr11:65267665-65267666(+) m6A exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr11:65267746-65267747(+) m6A exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:65267808-65267809(+) m6A exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:65267842-65267843(+) m6A exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr11:65267905-65267906(+) m6A exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr11:65267915-65267916(+) m6A exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr11:65267929-65267930(+) m6A exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr11:65267951-65267952(+) m6A exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr11:65267987-65267988(+) Am exon//intron       - chr11:65268041-65268042(+) m1A exon//intron       26863196 chr11:65268189-65268190(+) m6A exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:65268274-65268275(+) m6A exon//intron       24284625//24209618//24981863//26404942//27773535//22575960 chr11:65268437-65268438(+) m6A exon       24209618//24981863//26404942//27773535//22575960 chr11:65268508-65268509(+) m6A exon       24209618//26404942//27773535//22575960 chr11:65268536-65268537(+) m6A exon       24209618//26404942//27773535 chr11:65268605-65268606(+) Y exon       26075521 chr11:65268751-65268752(+) Y exon       25219674 chr11:65268794-65268795(+) m6A exon       24981863//26404942//27773535 chr11:65268823-65268824(+) m6A exon       24981863//26404942//27773535 chr11:65268850-65268851(+) m6A exon       24981863//26404942//27773535 chr11:65268944-65268945(+) m6A exon       24981863//26404942//27773535 chr11:65268969-65268970(+) m6A exon       24981863//26404942//27773535 chr11:65269084-65269085(+) m6A exon       24981863//26404942//27773535//22575960 chr11:65269126-65269127(+) m6A exon       24981863//26404942//27773535//22575960 chr11:65269138-65269139(+) m6A exon       24981863//26404942//27773535//22575960 chr11:65269234-65269235(+) m6A exon       24981863//26404942//27773535//22575960 chr11:65269410-65269411(+) m6A exon       26404942//27773535//22575960 chr11:65269424-65269425(+) m6A exon       26404942//27773535//22575960 chr11:65269653-65269654(+) m6A exon       26404942//22575960 chr11:65269781-65269782(+) m6A exon       26404942//22575960 chr11:65269793-65269794(+) m6A exon       26404942//22575960 chr11:65269944-65269945(+) m6A exon//intron       26404942 chr11:65269993-65269994(+) m6A exon//intron       26404942 chr11:65270088-65270089(+) m6A exon//intron       26404942 chr11:65270107-65270108(+) m6A exon//intron       26404942 chr11:65270175-65270176(+) m6A exon//intron       24981863//26404942//27773535//22575960//22608085 chr11:65270275-65270276(+) m6A exon//intron       24981863//26404942//27773535//22575960//22608085 chr11:65270391-65270392(+) Y exon       25219674//25192136//26075521 chr11:65270587-65270588(+) m6A exon//intron       24981863//26404942//27773535//22575960 chr11:65270641-65270642(+) m6A exon//intron       26404942 chr11:65270821-65270822(+) Y exon       25219674//25192136//26075521 chr11:65270825-65270826(+) m6A exon//intron       26404942 chr11:65271054-65271055(+) m6A exon//intron       26404942//27773535 chr11:65271079-65271080(+) m6A exon//intron       26404942//27773535 chr11:65271201-65271202(+) m6A exon//intron       26404942//27773535 chr11:65271214-65271215(+) m6A exon//intron       26404942//27773535 chr11:65271228-65271229(+) m6A exon//intron       26404942//27773535 chr11:65271279-65271280(+) m6A exon//intron       26404942//27773535//22575960 chr11:65271372-65271373(+) m6A exon//intron       26404942//27773535 chr11:65271690-65271691(+) m6A exon//intron       26404942 chr11:65271796-65271797(+) m6A exon       26404942 chr11:65272104-65272105(+) m6A exon//intron       26404942//22575960 chr11:65272155-65272156(+) m6A exon//intron       26404942 chr11:65272164-65272165(+) m6A exon//intron       26404942 chr11:65272190-65272191(+) m6A exon//intron       26404942 chr11:65272212-65272213(+) m6A exon//intron       26404942 chr11:65272292-65272293(+) m6A exon       26404942//27773535 chr11:65272303-65272304(+) m6A exon       26404942//27773535 chr11:65272334-65272335(+) m6A exon       26404942 chr11:65272371-65272372(+) m6A exon       26404942 chr11:65272376-65272377(+) m6A exon       26404942 chr11:65272405-65272406(+) m6A exon       26404942 chr11:65272436-65272437(+) m6A exon       26404942//27773535 chr11:65272472-65272473(+) m6A exon       26404942//27773535 chr11:65272486-65272487(+) m6A exon       26404942//27773535 chr11:65272494-65272495(+) m6A exon//intron       26404942//27773535 chr11:65272539-65272540(+) m6A exon//intron       26404942//27773535 chr11:65272594-65272595(+) m6A exon//intron       26404942 chr11:65272694-65272695(+) m6A exon//intron       26404942 chr11:65272725-65272726(+) m6A exon//intron       26404942 chr11:65272794-65272795(+) m6A exon//intron       26404942 chr11:65273061-65273062(+) m6A exon//intron       26404942//22575960 chr11:65273166-65273167(+) m6A exon//intron       26404942//27773535//22575960 chr11:65273223-65273224(+) m6A exon//intron       26404942//27773535//22575960 chr11:65273268-65273269(+) m6A exon//intron       26404942//27773535//22575960 chr11:65273278-65273279(+) m6A exon//intron       26404942//27773535//22575960 chr11:65273309-65273310(+) m6A exon//intron       26404942//27773535//22575960 chr11:65273328-65273329(+) m6A exon//intron       26404942//27773535//22575960 chr11:65273343-65273344(+) m6A exon//intron       26404942//27773535//22575960 chr11:65273361-65273362(+) Tm exon//intron       - chr11:65273412-65273413(+) m6A exon//intron       26404942//22575960 chr11:65273426-65273427(+) m6A exon//intron       26404942//22575960 chr11:65273435-65273436(+) m6A exon//intron       26404942//22575960 chr11:65273518-65273519(+) m6A exon//intron       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MALAT1	Chromatin Breast cancer cell line (SKBR3)     28652379 Chromatin HeLa-S3 cells|K562 cells     - Cytoplasm HEK-293T cells|Mammary epithelium cell line (HC11)     31863590 Cytoplasm Lung cancer cell lines (A549|H1299)     34012919 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Thyroid papillary carcinoma cell line (TPC-1)     29967342 Exosome HeLa cells     24205503 Exosome Serum     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)|K562 cells     - Mitochondrion HCC cell line (HepG2)     31218107 Nuclear speckle Breast cancer cell line (MCF-7)     28652379 Nuclear speckle Retinal microvascular endothelial cells     30815547 Nuclear speckle U2OS cells     31085639 Nuclear speckle HEK-293T cells|Mammary epithelium cell line (HC11)     31863590 Nuclear speckle HeLa-TO cells     22355166 Nucleolus K562 cells     - Nucleoplasm WI-38 cells     29133588 Nucleoplasm K562 cells     - Nucleus Human osteosarcoma cell line (U2OS)     28423669 Nucleus HeLa cells     28663102 Nucleus WI-38 cells     29133588 Nucleus Human brain microvascular endothelial cells     30419554 Nucleus Human cervical cancer cell line (HeLa)     28216671 Nucleus U2OS cells     28538188 Nucleus Breast cancer cell lines (MDA-MB-468|SKBR3)     28652379 Nucleus HeLa cells     29335281 Nucleus Lung cancer cell line (A549)     30548064 Nucleus Vascular smooth muscle cells     31696492 Nucleus Fibroblasts|Lymphoblasts     17270048 Nucleus Cell line (HeLa)     19041754 Nucleus HeLa cells     20797886 Nucleus Motor neurons     22070123 Nucleus Human cervical cancer cell line (HeLa)     22078878 Nucleus HeLa cells     22855529 Nucleus HeLa cells     23073843 Nucleus Cell line (HeLa)     23152763 Nucleus Colon cancer cells     24393600 Nucleus HeLa cells     25630241 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Speckle periphery HeLa cells|WI-38 cells     29133588
	hsa-miR-185-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Plasma     29130611 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Serum     25135963 Exosome Blood|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-185-5p	7-Epi-10-deacetylbaccatin III 9872117 Drug sensitive Midostaurin 9829523 Drug resistant Tiotixene 941651 Drug sensitive Acridine Yellow G 8672 Drug resistant 1,9-Pyrazoloanthrone 8515 Drug resistant Pingyangmycin 84046 Drug resistant Tanakan 83818 Drug sensitive 2,4,6-Tris(2-pyridyl)-s-triazine 77258 Drug sensitive Secalonic acid D 73431 Drug sensitive Coptisine chloride 72321 Drug sensitive 7-Hydroxystaurosporine 72271 Drug resistant Anaxirone 71218 Drug resistant Dihydroxydiphenyl-pyridyl methane 69046 Drug resistant Mevastatin 64715 Drug resistant Everolimus 6442177 Drug resistant Primaquine phosphate 6135 Drug sensitive 1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive 8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive Thiopyrimidine-CH3 5473238 Drug sensitive Iejimalide A. 5473233 Drug sensitive 11-Cyanomethylen-11H-indolo[1,2-a]indazole 5472501 Drug resistant 6-(4-Ethylphenyl)-2-benzenesulfonamidepyridazine-3(2H)-one 54612980 Drug sensitive Bleomycin 5460769 Drug resistant Herveline O 5459269 Drug sensitive [2-[2-[(1R,2S)-2-[[6-Amino-2-[1-[(2S)-2,3-diamino-3-oxopropyl]-4-oxoazetidin-2-yl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[(2R,3S,4S)-3-hydroxy-5-[[(2S,3R)-3-hydroxy-1-[2-[4-[4-[2-(2-hydroxypropylamino)ethylcarbamoyl]-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-1-oxobutan-2-yl]amino]-4-methyl-5-oxopentan-2-yl]amino]-1-(1H-imidazol-5-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl] carbamate 5458321 Drug resistant Melampodin B acetate 5359212 Drug sensitive 5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive Lovastatin 53232 Drug resistant Cytochalasin B 5311281 Drug resistant Herbimycin 5311102 Drug sensitive 5-Fluoro-2'-deoxycytidine 515328 Drug resistant Dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498558 Drug sensitive Staurosporine, 98% 49831000 Drug resistant 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 4713 Drug sensitive Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive 3-3'-(1H-Pyrazole-3,5-diyl)bis(1-methyl-1H-indole) 44433919 Drug resistant 4-[1-(4-Aminomethyl-phenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamine 44397453 Drug resistant 1-Benzyl-3-hexadecyl-2-methylimidazolium chloride 44219704 Drug sensitive Bleomycin-BAPP 431594 Drug resistant Bleomycin A5, sulfate 422920 Drug resistant Aminopyrimidine-CH3 406278 Drug sensitive 1H-Naphth[2,3-d]imidazole, 2-[(4-chlorophenyl)methyl]- 405626 Drug resistant Purpureagitosid 401298 Drug resistant Trapoxin B 395803 Drug sensitive 3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one 387973 Drug resistant 2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive 2-(3-Chloropropyloxy)naphthazarin 378771 Drug sensitive 5,8-Dihydroxy-2-(4-(2-pyridinyl)-1-piperazinyl)naphthoquinone 376947 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant 2,3-Bis(dodecanoyloxy)propylarsonic acid 375754 Drug sensitive Naphtho[2,3-f]quinoxaline-7,12-dione, 3-hydroxy-2-methyl- 371563 Drug resistant 1-(4-Methoxy-2-methylphenyl)naphtho[1,2-c]furan-3(1H)-one 369148 Drug sensitive 3,8,13,18,23-Pentaazapentacosane 368998 Drug sensitive 2,7-Dicyanoxanthone 363841 Drug sensitive Girolline 362388 Drug resistant 1,2,4,5-Tetrazine, 3,6-bis(1-azetidinyl)- 362170 Drug sensitive 7alpha-Acetoxyroylenane 362048 Drug sensitive Thiosangivamycin 3580213 Drug sensitive Imidazole, 1-(4-chlorophenyl)-4-(4-nitrophenyl)- 355940 Drug resistant 2,3-Dimethylbenzo[g]quinoxaline-5,10-dione 353644 Drug sensitive 1,4-Diaminoanthraquinone 31420 Drug resistant Clomifene citrate 3033832 Drug sensitive SMA-491 (free base of NSC D742838) 302576 Drug resistant Gardenin A 261859 Drug resistant Hookerianamide J 25016666 Drug sensitive Hookerianamide K 25016412 Drug sensitive (2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive CID 24197685 24197685 Drug sensitive Antibiotic U 29135 24196291 Drug sensitive 4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive Kinetin riboside 20345 Drug resistant Chonemorphine 165208 Drug sensitive (6R)-1,6,11-Trihydroxy-8-[(2S,4R,5R,6R)-4-hydroxy-5-[(2S,4R,5R,6R)-5-hydroxy-4-[(2S,5S,6S)-5-[(2S,4R,5R,6R)-4-hydroxy-5-[(2S,4R,5R,6R)-5-hydroxy-4-[(2S,5S,6S)-5-hydroxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-3-methyl-5,6-dihydrobenzo[a]anthracene-7,12-dione 15507920 Drug sensitive Ellipticine analog 148569 Drug resistant (2R)-2-Hydroxy-3-[(6R)-11-hydroxy-2-[4-[(6R)-4-hydroxy-2-[1-hydroxy-3-[(6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-8-yl]-2-methylpropanoic acid 146158002 Drug sensitive Astrazon Orange R 135747272 Drug sensitive [(8Ar)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2-methylbutanoate 134694047 Drug resistant Methyl (1S,10R,11S,12S)-11-acetyloxy-12-ethyl-4-[(13R,15R,17R)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 133126830 Drug sensitive (2R,4R,6S,7S,12S)-6,7,16-Trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo[13.4.0.02,4]nonadeca-1(15),9,16,18-tetraene-8,14-dione 131676399 Drug sensitive 1,4-Bis((2-aminoethyl)amino)-5,8-dihydroxy-9,10-anthraquinone 125982 Drug resistant Pepleo 122804 Drug resistant Cyanoaminopyranopyridine derivatives 11494577 Drug resistant 1-Phenyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazole 11162021 Drug resistant Uridine, 2'-deoxy-2'-methylene- 11075548 Drug resistant Acetylenedicarboxamide 10971 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive Binimetinib 10288191 Drug sensitive (1S,3R,6R,12S,14R,15S,18R,19E,21Z,25R,26S,27R)-6,15-Dihydroxy-18-[(1R)-1-hydroxyethyl]-5,14,26-trimethylspiro[2,10,13,17,24-pentaoxapentacyclo[23.2.1.03,8.08,26.012,14]octacosa-4,19,21-triene-27,2'-oxirane]-11,23-dione 101307863 Drug sensitive Selumetinib 10127622 Drug sensitive 1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion - Drug resistant 1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant 1-naphthalenecarboxamide, n,n'-1,8-(octanediyl)bis- - Drug resistant 6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione - Drug resistant 3-peg fudr (peg floxuridine) - Drug resistant 6-aryl alkyl fluoro quinolone derivative - Drug resistant Annamycin Liposomal - Drug resistant antineoplastic-d655481 - Drug resistant Camptothecin Derivative - Drug resistant geldanamycin dimethylglycinate - Drug resistant organosulfur compound - Drug resistant tartrolon a1 - Drug resistant toxin .delta.53l - Drug resistant tp4ek - Drug resistant viridomycin - Drug resistant (z) 3,3',4,5-tetramethoxystilbene - Drug sensitive 1,2-benzo-8-(d,l-alanyl)-3-phenoxazone nitrate salt - Drug sensitive 1-piperidinecarbodithioic acid, antimony complex - Drug sensitive 2-azabicyclo[16.3.1]docosane, geldanamycin deriv. - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 5,6-dimethyl-9-oxo-9h-xanthene-4-acetic acid, sodium salt - Drug sensitive benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive iodonium, (4-methoxyphenyl)(3-methylphenyl)-, bromide - Drug sensitive (Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive 1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive 5-hydroxyamino camptothecin - Drug sensitive antineoplastic-615538 - Drug sensitive dichlorobisoxinatotitanium(iv) - Drug sensitive geldanamycin deriv - Drug sensitive tetra(isobutenyl)antimony bromide - Drug sensitive xenorhabdin 1 - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	MALAT1	Vincristine 5978 Drug interaction    RC00000036
	hsa-miR-185-5p	Formaldehyde 712 Drug interaction    RC00003208 Oxaliplatine 6857599 Drug interaction    RC00003218 Gemcitabine 60750 Drug interaction    RC00003213 Cholesterol 5997 Drug interaction    RC00003211 Eloxatine 5310940 Drug interaction    RC00003217 Decitabine 451668 Drug interaction    RC00003215 5-Fluorouracil 3385 Drug interaction    RC00003210 Doxorubicin 31703 Drug interaction    RC00003212 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003209 Tamoxifen 2733526 Drug interaction    RC00003216 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00003219 Benzene 241 Drug interaction    RC00003207 Leucovorin 135403648 Drug interaction    RC00003220

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-185-5p	Cisplatin 5702198       27906433 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	MALAT1	6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide       9956222 6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile       9956119 Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-       9952773 5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride       9938202 Rucaparib       9931954 1,2-Ethanediamine, N-(1,8-dimethylimidazo(1,2-a)quinoxalin-4-yl)-, monohydrochloride       9926054 Tivozanib       9911830 Zibotentan       9910224 5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide       9903786 PI-103       9884685 Osi-930       9868037 5Z-7-Oxozeaenol       9863776 2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine       9858940 4-[4-(2,3-Dihydro-1,4-benzodioxin-6-YL)-3-methyl-1H-pyrazol-5-YL]-6-ethylbenzene-1,3-diol       984170 Midostaurin       9829523 N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528 8-Hydroxy-7-(6-sulfo-naphthalen-2-ylazo)-quinoline-5-sulfonic acid       92577 1,9-Pyrazoloanthrone       8515 Phenformin       8249 (E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one       78243717 2-Methoxy-N-(3-Methyl-2-Oxo-1,2,3,4-Tetrahydroquinazolin-6-Yl)benzenesulfonamide       71271629 N-(3-Methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine       704473 (S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide       6918848 Panobinostat       6918837 Belinostat       6918638 2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide       6918454 Temsirolimus       6918289 Daporinad       6914657 N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide       6852167 AICA ribonucleotide       65110 Tanespimycin       6505803 Ispinesib mesylate       6450816 Axitinib       6450551 Pelitinib       6445562 Piperlongumine       637858 Cytarabine       6253 Gemcitabine       60750 Mitomycin       5746 5-[2-[4-(Aminomethyl)phenyl]-5-pyridin-4-yl-1H-imidazol-4-yl]-2-chlorophenol;hydrochloride       57399803 1-[4-[4-Amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl]phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea;hydrochloride       57391096 (2-(Phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone)       57339144 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea       56962337 Dimethyloxalylglycine       560326 l-685,458       5479543 Austocystin D       5470400 2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid       54685215 Temozolomide       5394 1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]-       5351150 N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide       53340664 Palbociclib       5330286 Bosutinib       5328940 Vorinostat       5311 Bryostatin 1       5280757 2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one       5278396 Bis(2-hydroxy-1-naphthyl) disulfide       521106 2-{[4-(5-Ethylpyrimidin-4-Yl)piperazin-1-Yl]methyl}-5-(Trifluoromethyl)-1h-Benzimidazole       51371303 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide       5113032 Dichloroplatinum; 2-(4-methoxyphenyl)ethanamine       498558 Tubastatin A       49850262 Alectinib       49806720 2-[(4s)-6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-4h-[1,2,4]triazolo[4,3-A][1,4]benzodiazepin-4-Yl]-N-Ethylacetamide       46943432 (S)-(+)-Tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate       46907787 3-(4-(4-(2-(3-((Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea       46885626 Avagacestat       46883536 2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine       46224516 N-(6,6-Dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-methylbutanamide       46191454 Epothilone B       448013 N-(2,2,2-Trifluoroethyl)-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}benzenesulfonamide       447912 1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine       44551660 Tretinoin       444795 Dabrafenib       44462760 Refametinib       44182295 Foretinib       42642645 Benzofurazan, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide       42640 (2S)-2-[[2-(2,3-Dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]-6-purinyl]amino]-3-phenyl-1-propanol       42623900 Mercury, chloro-2-naphthalenyl-       425433 Janus Red B       407803 Benzenamine, 4-(5,6-difluoro-2-benzothiazolyl)-2-methyl-       400168 4-N-(3-Bromophenyl)pyrido[4,3-d]pyrimidine-4,7-diamine;methanesulfonic acid       382058 Arborescidine D       378619 Etoposide       36462 3,4-Dihydroxynaphthalene-2-carboxylic acid       356138 5-Fluorouracil       3385 N6-Benzyladenosine-5'-phosphate       318601 AT 116, benzylamine salt       282523 Tamoxifen       2733526 [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol       25262965 2-(4-Methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide       25257557 Ruxolitinib       25126798 Cabozantinib       25102847 Navitoclax       24978538 MK-2206       24964624 Tert-Butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate       24951314 Quizartinib       24889392 Ponatinib       24826799 Vismodegib       24776445 4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide       24772860 Cudc-101       24756910 Vincaleukoblastine       241903 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide       24180719 Bicalutamide       2375 Olaparib       23725625 (2E,5E)-2,5-Bis(thiophen-2-ylmethylene)cyclopentanone       2314623 Nutlin-3       216345 Lenalidomide       216326 Enzastaurin       176167 4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide       16747388 Gsk-690693       16725726 Fedratinib       16722836 3-[(1-Methyl-3-indolyl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one       16219401 N-(3-{[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-[2-(morpholin-4-yl)ethoxy]benzamide       16095342 1-(Tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea       1401 (Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide       135659062 (E)-5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime       135421339 Pac-1       135421197 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one       135418940 Osi-027       135398516 Dovitinib       135398510 Akt inhibitor VIII       135398501 Methotrexate       126941 Lestaurtinib       126565 Gefitinib       123631 Dactolisib       11977753 Veliparib       11960529 BAY 61-3606 dihydrochloride       11784504 N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-YL)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide       11754511 Trametinib       11707110 Motesanib       11667893 4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine       11647372 4-[2-(2-Chloro-4-fluoroanilino)-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide       11634725 Idelalisib       11625818 JNK Inhibitor VIII       11624601 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine       11617559 Benzamide, 4-((1R)-1-aminoethyl)-N-1H-pyrrolo(2,3-b)pyridin-4-yl-, hydrochloride (1:1)       11507964 5-(2-Phenylpyrazolo[1,5-A]pyridin-3-YL)-1H-pyrazolo[3,4-C]pyridazin-3-amine       11493598 Linifanib       11485656 N-(6-Fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide       11373846 4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide       11338033 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one       11327430 Pararosaniline hydrochloride       11292 Amuvatinib       11282283 (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide       11152667 7-Ethyl-10-hydroxycamptothecin       104842 5,7-Dihydroxy-2-(4-Hydroxyphenyl)-4-Oxo-4h-Chromen-3-Yl 3,4-Di-O-Acetyl-6-Deoxy-alpha-L-Mannopyranoside       10459196 VX-702       10341154 Afatinib       10184653 Selumetinib       10127622 Pazopanib       10113978 N-(3-{[5-Iodo-4-({3-[(Thiophen-2-Ylcarbonyl)amino]propyl}amino)pyrimidin-2-Yl]amino}phenyl)pyrrolidine-1-Carboxamide       10077147 Masitinib       10074640 25-Dihydrosaframycin A       100180 Basic Fuchsin       - Bleomycin (50 uM)       - Cetuximab       - Cisplatin       - Cobimetinib (isomer 1)       - [co(me2dtc)2(dee)]clo4       - copper(ii) ocetanedioate 1,10-phenanthroline perchlorate       - Genentech Cpd 10       - JQ12       - JW-7-24-1       - KIN001-236       - KIN001-244       - KIN001-260       - KIN001-266       - KIN001-270       - MPS-1-IN-1       - NPK76-II-72-1       - Nutlin-3a (-)       - QL-X-138       - QL-XI-92       - rhodium dimer       - rTRAIL       - SB52334       - THZ-2-102-1       - THZ-2-49       - TL-1-85       - TL-2-105       - Tyrothricin       - VNLG/124       - WZ3105       - XMD13-2       - XMD14-99       - XMD15-27       -

Interaction Network (The top 100 interactions):

Interactor1: MALAT1
Interactor2: hsa-miR-185-5p

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA
Support Database	ViRBase

References:

PMID	31199512	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	293 cells//C2089 cells//C22 cells	Interactor2 expression	None
Description	Figure 5 Target genes of the EBV-related lncRNAs. Online software program search results demonstrated that four lncRNAs target two common genes, FUS and U2AF65; three lncRNAs commonly target UPF1; and five lncRNAs target one common gene, eIF4AIII, as indicated in the red boxes. Interactions were also predicted between lncRNAs and miRNAs.