Detail Information

Basic Information:


  VIRBase ID:  

HHID00038584

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      BCYRN1:           hsa-miR-9-5p:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol BCYRN1 hsa-miR-9-5p
miRBase
Accession/Entrez ID		 618 MIMAT0000441
Organism Homo sapiens Homo sapiens
Category lncRNA miRNA
Alias BC200//BC200a//LINC00004//NCRNA00004 -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt PMID
LincSNP 3.0 BCYRN1
rs10865224 chr2:47338656 G/T         19197363
rs17036504 chr2:47340190 A/G         19875103
rs13388259 chr2:47343700 A/C         21886157
rs10514804 chr2:47336434 A/G         21886157
rs4422207 chr2:47336895 A/G         22233810

RNA Editing:


Resource Symbol Editing Position
Lncediting BCYRN1
    chr2: 47563133
    chr2: 47565123
    chr2: 47565149
    chr2: 47565158
    chr2: 47565166
    chr2: 47565181
Resource Symbol Editing Position Change Genetic Region
RADAR BCYRN1
chrX:70604430(-) A-I      intronic
chrX:70442256(-) A-I      intronic
chrX:70674220(-) A-I      intronic
chrX:70674311(-) A-I      intronic
chrX:70688453(-) A-I      intronic
chrX:70689823(-) A-I      intronic
chrX:70689824(-) A-I      intronic
chrX:70689832(-) A-I      intronic
chrX:70697339(-) A-I      intronic
chrX:70697436(-) A-I      intronic
chrX:70701085(-) A-I      intronic
chrX:70703431(-) A-I      intronic
chrX:70709469(-) A-I      intronic
chrX:70710746(-) A-I      intronic
chrX:70747192(-) A-I      intronic
chr2:47565181(+) A-I      ncRNA
chrX:70639922(-) A-I      intronic
chrX:70639925(-) A-I      intronic
chr2:47565166(+) A-I      ncRNA
chr2:47565158(+) A-I      ncRNA
chrX:70710834(-) A-I      intronic
chr2:47565149(+) A-I      ncRNA
chr2:47565123(+) A-I      ncRNA
chrX:70442253(-) A-I      intronic
chrX:70502081(-) A-I      intronic
chrX:70710842(-) A-I      intronic
chrX:70502078(-) A-I      intronic
chrX:70507309(-) A-I      intronic
chrX:70639964(-) A-I      intronic
chrX:70639969(-) A-I      intronic
chrX:70639979(-) A-I      intronic
chrX:70640455(-) A-I      intronic
chrX:70679955(-) A-I      intronic
chrX:70640516(-) A-I      intronic
chrX:70640520(-) A-I      intronic
chrX:70860365(-) A-I      intronic
chrX:70640544(-) A-I      intronic
chrX:70857567(-) A-I      intronic
chrX:70885944(-) A-I      intronic
chrX:70885948(-) A-I      intronic
chrX:70885952(-) A-I      intronic
chrX:70857557(-) A-I      intronic
chrX:70806465(-) A-I      intronic
chrX:70885985(-) A-I      intronic
chrX:70502068(-) A-I      intronic
chrX:70508325(-) A-I      intronic
chrX:70581354(-) A-I      intronic
chrX:70581357(-) A-I      intronic
chrX:70583787(-) A-I      intronic
chrX:70885943(-) A-I      intronic
chrX:70583788(-) A-I      intronic
chrX:70860366(-) A-I      intronic
chrX:70778697(-) A-I      intronic
chrX:70773168(-) A-I      intronic
chrX:70507504(-) A-I      intronic
chrX:70507320(-) A-I      intronic
chrX:70585479(-) A-I      intronic
chrX:70585483(-) A-I      intronic
chrX:70885955(-) A-I      intronic
chrX:70640521(-) A-I      intronic
chrX:70885956(-) A-I      intronic
chrX:70640497(-) A-I      intronic
chr2:47563133(+) A-I      ncRNA
chrX:70533075(-) A-I      intronic
chrX:70502123(-) A-I      intronic
chrX:70584304(-) A-I      intronic
chrX:70552143(-) A-I      intronic
chrX:70584560(-) A-I      intronic
chrX:70491204(-) A-I      intronic
chrX:70844080(-) A-I      intronic
chrX:70482863(-) A-I      intronic
chrX:70502096(-) A-I      intronic
chrX:70446233(-) A-I      intronic
chrX:70860909(-) A-I      intronic
chrX:70548699(-) A-I      intronic
chrX:70583319(-) A-I      intronic
chrX:70583324(-) A-I      intronic
chrX:70502109(-) A-I      intronic
chrX:70584568(-) A-I      intronic
chrX:70501781(-) A-I      intronic
chrX:70582087(-) A-I      intronic
chrX:70892887(-) A-I      intronic
chrX:70495938(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED BCYRN1
chrX:70484034(-) T-C intron -    22484847
chrX:70530525(-) T-C intron -    22484847
chrX:70530526(-) T-C intron -    22484847
chrX:70530900(-) T-C intron -    22484847
chrX:70538419(-) T-C intron -    22484847
chrX:70542792(-) T-C intron -    22484847
chrX:70574533(-) T-C intron -    22484847
chrX:70575001(-) T-C intron -    22484847
chrX:70575128(-) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BCYRN1
chr2:47562538-47562539(+) m6A exon       24981863
chr2:47562561-47562562(+) m6A exon       24981863
chr2:47562592-47562593(+) m6A exon       24981863
chr2:47562599-47562600(+) m6A exon       24981863
chr2:47563674-47563675(+) m6A exon       25456834//27773535
chr2:47563736-47563737(+) m6A exon       25456834//27773535
chr2:47563836-47563837(+) m6A exon       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate BCYRN1
Exosome Serum     -
hsa-miR-9-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome B cell line (Raji)|Jurkat-derived T cell line (J77cl20)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Blood|Chronic lymphocytic leukemia cells|Tongue tissue     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293)     22984580
Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-9-5p
Succinimide, 3-chloro-N-(p-methoxyphenyl)- 99724 Drug resistant
Iodine Green 9956454 Drug sensitive
7-Epi-10-deacetylbaccatin III 9872117 Drug sensitive
2-Methylthio-1,4-naphthoquinone 96324 Drug resistant
5-Iodo-8-quinolinol 96111 Drug sensitive
Acnistin F 6712173 Drug resistant
Pyrazolo[1,5-b]pyridazine deriv. 97 6539439 Drug resistant
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
5-Bromo-3-(2-oxo-2-phenylethylidene)-1,3-dihydroindol-2-one 5477132 Drug resistant
Kijanimicin sodium salt 54707591 Drug sensitive
Antineoplastic-643001 5466797 Drug sensitive
Di-p-tolyliodinium bromide 54601177 Drug sensitive
Simvastatin 54454 Drug sensitive
Vorinostat 5311 Drug sensitive
Eupachlorin 5281446 Drug resistant
Spiperone 5265 Drug resistant
Pipamperone 4830 Drug sensitive
Tiazofurin 457954 Drug sensitive
5-Iodo-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 45029271 Drug sensitive
Suavedol 442245 Drug sensitive
Triciribine phosphate 43860 Drug resistant
Antibiotic X-14766A 434840 Drug sensitive
Di-n-octyl-secalonsaure A 430141 Drug sensitive
11-Hydroxyusambarine Chlorhydrate 401426 Drug sensitive
2-(1-Propynyl)estradiol 388008 Drug sensitive
Stereoisomer of NSC 674066-O 384359 Drug sensitive
2-Ethylaminoestradiol 384235 Drug sensitive
Sanguilutine pseudobase 371258 Drug sensitive
7-Chloro-1-methyl-phenothiazone 369386 Drug sensitive
Diethoxybis(1,4-naphthochinone-2-olato)titanium(IV) 368297 Drug sensitive
Diisopropoxybis(1,4-naphthochinone-2-olato)titanium(IV) 368058 Drug sensitive
1,2,4,5-Tetrazine, 3,6-bis(1-azetidinyl)- 362170 Drug sensitive
Hexachlorophene 3598 Drug sensitive
2,3-Dimethylbenzo[g]quinoxaline-5,10-dione 353644 Drug sensitive
L-Cysteine, S-[bis(4-methylphenyl)phenylmethyl]- 275979 Drug sensitive
L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug sensitive
9H-Purine, 6-(benzylthio)-9-(2-chloroethyl)- 246230 Drug sensitive
1,2-Benzo-8-(L-alanyl)-3-phenoxazone nitrate salt 24202491 Drug sensitive
1-(2-(Dimethylamino)ethyl)-3-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)urea 23634407 Drug sensitive
4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-imidazol-1-yl]-cyclohexanol 22464120 Drug resistant
2,2'-Bioxirane 11254 Drug sensitive
Waol A FD-211 10354084 Drug resistant
4-piperidinone, 1-methyl-2,6-bis[(2-nitrophenyl)methylene]- - Drug resistant
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
o-linoleoyl-6-d-glucose - Drug resistant
sphinxolide f - Drug resistant
1,2-benzo-8-(d,l-alanyl)-3-phenoxazone nitrate salt - Drug sensitive
2-(4-(methylsulfonyl)phenyl)-6-p-tolyl-4,5-dihydropyridazin-3(2H)-one - Drug sensitive
2-(naphthalen-2-yl)-1-(3,4,5-trimethoxyphenyl)-1h-imidazole - Drug sensitive
3-piperidinone, 3,5-bis[(3,4-dichlorophenyl)methylene]- - Drug sensitive
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, diacetate - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
l-cysteine, s-[(4-methylphenyl)diphenylmethyl]- (9ci) - Drug sensitive
Basic Fuchsin - Drug sensitive
Camptothecin Derivative - Drug sensitive
cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-9-5p
Rucaparib phosphate 9931953 Drug interaction    RC00003010
Formaldehyde 712 Drug interaction    RC00002988
Gemcitabine 60750 Drug interaction    RC00003004
Vincristine 5978 Drug interaction    RC00002997
D-Glucose 5793 Drug interaction    RC00002996
Estradiol 5757 Drug interaction    RC00002995
Prednisolone 5755 Drug interaction    RC00002994
Temozolomide 5394 Drug interaction    RC00002993
Sulindac sulfide 5352624 Drug interaction    RC00003009
Eloxatine 5310940 Drug interaction    RC00003008
Imatinib 5291 Drug interaction    RC00002992
Fenretinide 5288209 Drug interaction    RC00003007
Goserelinacetate 47725 Drug interaction    RC00003003
Diethylstilbestrol 448537 Drug interaction    RC00003006
Etoposide 36462 Drug interaction    RC00003002
Paclitaxel 36314 Drug interaction    RC00003001
Doxorubicin 31703 Drug interaction    RC00003000
Daunorubicin 30323 Drug interaction    RC00002999
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002991
Carmustine 2578 Drug interaction    RC00002990
[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol 25262965 Drug interaction    RC00003011
Bicalutamide 2375 Drug interaction    RC00002989
Arsenic trioxide 14888 Drug interaction    RC00002998
Docetaxel 148124 Drug interaction    RC00003005
Asparaginase Escherichia coli - Drug interaction    RC00003012
TRAIL therapy - Drug interaction    RC00003013
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003014
Iron-sulfates and Aluminum-sulfates - Drug interaction    RC00003015
Resource Symbol Drug Name PubChem ID
RNAactDrug BCYRN1
2-(((5-(4-(4-(3-Fluorobenzyloxy)-3-chlorophenylamino)quinazolin-6-yl)furan-2-yl)methyl)(2-(methylsulfonyl)ethyl)amino)acetonitrile       9873849
9H-Purine, 6-(ethylthio)-9-beta-D-ribofuranosyl-(8CI)(9CI)       95846
6-Benzylthioinosine       95263
Tiotixene       941651
Acridine Yellow G       8672
Sulfonaphtholazoresorcinol       85517
Benzethonium chloride       8478
3-Amino-7-(dimethylamino)-5-phenylphenazinium chloride       75442
Berberine iodide       72350
3-Hydroxy-3'-nitro-2-naphthanilide       67277
Hypopistephanine       6711179
Triciribine       65399
4-[2-(4-Fluorophenyl)-6-methylpyrazolo[1,5-b]pyridazin-3-yl]-N-phenylpyrimidin-2-amine       6539440
4-(N-Hydroxyacetamido)stilbene       6433723
Primaquine phosphate       6135
3-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)phenol;hydrochloride       57399804
5-[2-[4-(Aminomethyl)phenyl]-5-pyridin-4-yl-1H-imidazol-4-yl]-2-chlorophenol;hydrochloride       57399803
Phyllanthastatin 1       5477587
Austocystin D       5470400
3-{(2-Carboxy-ethyl)-[4-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-phenyl]-amino}-propionic acid       5469598
Mito-tempol       54613387
Olivomycin Transformation       54610760
Herveline O       5459269
(10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone       5459202
1-[2-[p-[alpha-(p-Methoxyphenyl)-beta-nitrostyryl]phenoxy]ethyl]pyrrolidine citrate (1:1)       5381092
Zimeldine       5365247
Rubremetinium chloride       5351504
Chlorprothixene hydrochloride       5282478
Isotretinoin       5282379
Alsterpaullone       5005498
Phenylmethylsulfonyl fluoride       4784
2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one       4713
Okadaic acid       446512
Dabrafenib       44462760
Ouabain       439501
Vemurafenib       42611257
1,6-Bis[4-(4-aminophenoxy)phenyl]diamantane       397904
Ptilomycalin A format salt       395755
9-(5-Nitropyridin-2-yl)-3H-purine-2,6-dione       389377
N, O-Diethoxyacetyl-3-demethyldeactylthiocolchicin       379556
Diisopropoxybis(1,4-naphthochinone-2-olato)titanium(IV)       368058
1,2,4,5-Tetrazine, 3,6-bis(1-azetidinyl)-       362170
1,7-Diiminopyrrolo[3,4-f]isoindole-3,5-diamine       359178
3,4-Dihydroxynaphthalene-2-carboxylic acid       356138
Thymolphthalein       31316
Cytosine, 1beta-D-arabinofuranosyl-N(sup 4)-stearoyl-       304673
Clomifene citrate       3033832
AT 116, benzylamine salt       282523
(2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide       24200489
Arenaemycin E       24199350
6-Chloro-2-methoxy-9-[(5-piperidinopentyl)amino]acridine       219600
Thalicarpine       21470
Kinetin riboside       20345
Adiantifoline       167937
Mercury, (acetyloxy)(pentamethylphenyl)-       16683786
Chonemorphine       165208
Basic violet 2       14454445
N-[5-[5-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-pyridin-4-ylfuran-3-yl]-2,3-dihydroinden-1-ylidene]hydroxylamine;hydrochloride       136207967
4-[(5z)-5-(1-Nitroso-2,3-Dihydro-5h-Inden-5-Ylidene)-2-(Piperidin-4-Yl)-3,5-Dihydro-4h-Imidazol-4-Ylidene]-1,4-Dihydropyridine       136026031
Astrazon Orange R       135747272
N,N-Dimethyl-2-[4-[4-(1-nitroso-2,3-dihydroinden-5-ylidene)-5-(1H-pyridin-4-ylidene)-1H-imidazol-2-yl]phenoxy]ethanamine       135564599
Acid orange 7       135442941
Abiraterone       132971
Berberine chloride       12456
(Z)-But-2-enedioic acid;3-[4-[(3Z)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]-N-methylpropanamide       11954261
(S)-N-((S)-1-Cyclohexyl-2-oxo-2-((3aR,7aS)-6-phenethyloctahydro-1H-pyrrolo[2,3-c]pyridin-1-yl)ethyl)-2-(methylamino)propanamide       11503417
Bafetinib       11387605
Pararosaniline hydrochloride       11292
Setoglaucine       107404
[(4-Methylphenyl)methyl](triphenyl)arsanium bromide       10672721
Dequalinium chloride       10649
Saframycin A       100594
25-Dihydrosaframycin A       100180
3-pyridinecarboxamide, 6-(hydroxyazo)-, sodium salt       -
;4-fluoro-N-(3-(4-(6-(4-hydroxyphenyl)imidazo[2,1-b]thia...       -
5,6-ethylenediquino[3,2-b       -
;9-benzyl-7-benzyloxy-2-benzyl-1-methyl-9H-carbolinium b...       -
.alpha.-sarcin       -
Basic Fuchsin       -
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate       -
benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 3-methyl-       -
benzo[b]naphtho[2,3-d]furan-6,11-dione, 4-chloro-3-hydroxy       -
bis-.mu.-propionatodiaquatetrabromorhenium(ii)       -
crotoxin cd       -
Denileukin Diftitox Ontak       -
;(E)-2-methyl-10-(3,4,5-trimethoxybenzylidene)-5-(3,4,5-...       -
gamitrinib-g4       -
gramicidin       -
g-tpp       -
Hypothemycin       -
indoline, 5-chloro-1,3,3-trimethyl-2-methylene- (8ci)       -
naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)-       -
naphtho[2,1-b]quinolizinium, 5-chloro-7-methyl- perchlorate       -
naphtho[2,3-b]furan-4,9-dione, 2-bromo-       -
N-methyl-N-(4-(3-(pyrrolidin-1-yl)propoxy)benzyl)-4-(2,6...       -
pararosaniline pamoate       -
protein toxin a 23 - mw approx. 6700       -
protein toxin b 15 - mw approx 6700       -
protein toxin c 10 - mw approx. 6700       -
rhodium dimer       -
riboprine(usan)       -
tp38-279       -
tp4ek-k6       -
tp4ek       -
Tyrothricin       -

Interaction Network (The top 100 interactions):


Interactor1: BCYRN1
Interactor2: hsa-miR-9-5p

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA
Support Database ViRBase

References:


PMID 31199512 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line 293 cells//C2089 cells//C22 cells Interactor2 expression None
Description Figure 5 Target genes of the EBV-related lncRNAs. Online software program search results demonstrated that four lncRNAs target two common genes, FUS and U2AF65; three lncRNAs commonly target UPF1; and five lncRNAs target one common gene, eIF4AIII, as indicated in the red boxes. Interactions were also predicted between lncRNAs and miRNAs.

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