Detail

Basic Information:

VIRBase ID:

HHID00038568

Virus:

Human betaherpesvirus 5 (HHV-5)

Host:

Homo sapiens

Confidence Score:

0.6666

Interaction Type:

Host-Host interaction

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4521	hsa_circ_0000894
miRBase Accession/Entrez ID	MIMAT0019058	hsa_circ_0000894
Organism	Homo sapiens	Homo sapiens
Category	miRNA	circRNA
Alias	-	-

ncRNA SNP information:

Resource

Symbol

SNP ID

SNP Position

Ref/Alt

miRNASNP-v3

hsa-miR-4521

rs1011991709	chr17:8186962	G/A
rs1011991709	chr17:8186962	G/C
rs1041768648	chr17:8186965	C/T
rs1056190393	chr17:8186959	C/A
rs1231036635	chr17:8186958	T/A
rs1231036635	chr17:8186958	T/G
rs1316923680	chr17:8186964	G/A
rs1316923680	chr17:8186964	G/C
rs1316923680	chr17:8186964	G/T
rs1365122718	chr17:8186957	G/C
rs559116584	chr17:8186963	T/C
rs559116584	chr17:8186963	T/G
rs561824123	chr17:8186969	G/A
rs768576971	chr17:8186966	T/A
rs768576971	chr17:8186966	T/C
rs776348878	chr17:8186967	C/A
rs893173803	chr17:8186960	C/G
rs893173803	chr17:8186960	C/T
rs999343007	chr17:8186968	A/G
rs1310598293	chr17:8186951	A/G
rs928871091	chr17:8186953	G/A
rs928871091	chr17:8186953	G/C
rs937623219	chr17:8186954	G/A
rs953552065	chr17:8186949	C/A
rs953552065	chr17:8186949	C/G
rs953552065	chr17:8186949	C/T
rs962385560	chr17:8186955	A/G

RNA Localization:

Resource

Symbol

Subcellular Localization

Tissue or Cell Line

PMID

RNALocate

hsa-miR-4521

Exosome	B cell lymphoma cell lines\|EBV-transformed lymphoblastoid B cells	25242326
Exosome	Breast milk\|Cell lines\|Epididymal epithelial cells\|Osteoblast\|Plasma\|Primary glioblastoma neurosphere cells\|Primary keratinocyte\|Saliva\|Serum\|Urine	-
Microvesicle	Fibroblasts\|Mesenchymal stem cells	-

hsa_circ_0000894

Exosome

Blood

-

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4521

Interactor2: hsa_circ_0000894

Evidence Support:

Weak-Evidence	Illumina sequencing//Sanger sequencing
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase

References:

PMID	30576257	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	THP1 cells	Interactor2 expression	None
Description	Similarly, the same microRNA could bind to multiple circRNAs, and these include the top 10 microRNAs differently expressed in mock-infected vs. latent-infected THP-1 cells we had detected previously (38), which are listed in Table 3.