Detail

Basic Information:

VIRBase ID:

HHID00038561

Virus:

Human betaherpesvirus 5 (HHV-5)

Host:

Homo sapiens

Confidence Score:

0.6666

Interaction Type:

Host-Host interaction

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-378c	hsa_circ_0066631
miRBase Accession/Entrez ID	MIMAT0016847	hsa_circ_0066631
Organism	Homo sapiens	Homo sapiens
Category	miRNA	circRNA
Alias	-	-

ncRNA SNP information:

Resource

Symbol

SNP ID

SNP Position

Ref/Alt

miRNASNP-v3

hsa-miR-378c

rs1031754294	chr10:130962637	C/G
rs1187159745	chr10:130962648	C/G
rs1255712575	chr10:130962658	T/TG
rs924224817	chr10:130962645	A/G
rs936928990	chr10:130962646	C/T
rs1476405711	chr10:130962652	G/GT
rs954998865	chr10:130962654	C/G

RNA Localization:

Resource

Symbol

Subcellular Localization

Tissue or Cell Line

PMID

RNALocate

hsa-miR-378c

Exosome	Plasma	23663360
Exosome	Colon cancer cell line (LIM1863)	25330373
Exosome	Breast milk\|Cell lines\|Epididymal epithelial cells\|Osteoblast\|Plasma\|Primary glioblastoma neurosphere cells\|Primary keratinocyte\|Saliva\|Serum\|Urine	-
Microvesicle	Seminal plasma	23539611
Microvesicle	Serum	24797360
Microvesicle	Colon cancer cell line (LIM1863)\|Fibroblasts\|Mesenchymal stem cells\|Urine	-
Mitochondrion	Cell line (HEK-293\|HeLa)	22984580

hsa_circ_0066631

Exosome

Blood

-

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-378c

Interactor2: hsa_circ_0066631

Evidence Support:

Weak-Evidence	Illumina sequencing//Sanger sequencing
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase

References:

PMID	30576257	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	THP1 cells	Interactor2 expression	None
Description	Similarly, the same microRNA could bind to multiple circRNAs, and these include the top 10 microRNAs differently expressed in mock-infected vs. latent-infected THP-1 cells we had detected previously (38), which are listed in Table 3.