Detail Information

Basic Information:


  VIRBase ID:  

HHID00038541

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.7802

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-372-3p:           MICA:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-372-3p MICA
miRBase
Accession/Entrez ID		 MIMAT0000724 100507436
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - MIC-A//PERB11.1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-372-3p
rs1217326138 chr19:53787943    C/A
rs1279555777 chr19:53787952    G/T
rs1301421613 chr19:53787952    GTCACCGGTGACGCCCATA/G
rs1354263786 chr19:53787948    G/A
rs1430584044 chr19:53787941    G/A
rs1430584044 chr19:53787941    G/C
rs373851786 chr19:53787939    G/A
rs770639959 chr19:53787950    G/A
rs771431970 chr19:53787951    C/T
rs1252830095 chr19:53787935    T/A
rs1460843992 chr19:53787913    ATTCTGATGTCCAAGTGGAAAGT/A
rs1481131237 chr19:53787932    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MICA
chr6:31376765(+) A-I      intronic
chr6:31376737(+) A-I      intronic
chr6:31376723(+) A-I      intronic
chr6:31376688(+) A-I      intronic
chr6:31376582(+) A-I      intronic
chr6:31376581(+) A-I      intronic
chr6:31383250(+) A-I      3'UTR
chr6:31383331(+) A-I      3'UTR
chr6:31383615(+) A-I      3'UTR
chr6:31383320(+) A-I      3'UTR
chr6:31383275(+) A-I      3'UTR
chr6:31383276(+) A-I      3'UTR
chr6:31369971(+) A-I      5'UTR
chr6:31383273(+) A-I      3'UTR
chr6:31383269(+) A-I      3'UTR
chr6:31383172(+) A-I      3'UTR
chr6:31369972(+) A-I      5'UTR
chr6:31383186(+) A-I      3'UTR
chr6:31383621(+) A-I      3'UTR
chr6:31369980(+) A-I      5'UTR
chr6:31383652(+) A-I      3'UTR
chr6:31383724(+) A-I      3'UTR
chr6:31369937(+) A-I      5'UTR
chr6:31369946(+) A-I      5'UTR
chr6:31383345(+) A-I      3'UTR
chr6:31383354(+) A-I      3'UTR
chr6:31383693(+) A-I      3'UTR
chr6:31383589(+) A-I      3'UTR
chr6:31383584(+) A-I      3'UTR
chr6:31383549(+) A-I      3'UTR
chr6:31383511(+) A-I      3'UTR
chr6:31383475(+) A-I      3'UTR
chr6:31383471(+) A-I      3'UTR
chr6:31383455(+) A-I      3'UTR
chr6:31383535(+) A-I      3'UTR
chr6:31375196(+) A-I      intronic
chr6:31375034(+) A-I      intronic
chr6:31383694(+) A-I      3'UTR
chr6:31383571(+) A-I      3'UTR
chr6:31383684(+) A-I      3'UTR
chr6:31383501(+) A-I      3'UTR
chr6:31383180(+) A-I      3'UTR
chr6:31383606(+) A-I      3'UTR
chr6:31383561(+) A-I      3'UTR
chr6:31383314(+) A-I      3'UTR
chr6:31383597(+) A-I      3'UTR
chr6:31383181(+) A-I      3'UTR
chr6:31383709(+) A-I      3'UTR
chr6:31383340(+) A-I      3'UTR
chr6:31383632(+) A-I      3'UTR
chr6:31383463(+) A-I      3'UTR
chr6:31383712(+) A-I      3'UTR
chr6:31383235(+) A-I      3'UTR
chr6:31383324(+) A-I      3'UTR
chr6:31383575(+) A-I      3'UTR
chr6:31383532(+) A-I      3'UTR
chr6:31383617(+) A-I      3'UTR
chr6:31383355(+) A-I      3'UTR
chr6:31383344(+) A-I      3'UTR
chr6:31383328(+) A-I      3'UTR
chr6:31383158(+) A-I      3'UTR
chr6:31383384(+) A-I      3'UTR
chr6:31383379(+) A-I      3'UTR
chr6:31383573(+) A-I      3'UTR
chr6:31383624(+) A-I      3'UTR
chr6:31383278(+) A-I      3'UTR
chr6:31383558(+) A-I      3'UTR
chr6:31376549(+) A-I      intronic
chr6:31375044(+) A-I      intronic
chr6:31376635(+) A-I      intronic
chr6:31375062(+) A-I      intronic
chr6:31376525(+) A-I      intronic
chr6:31375187(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MICA
chr6:31367643-31367644(+) m6A 5'UTR       -
chr6:31367715-31367716(+) m6A 5'UTR       -
chr6:31367895-31367896(+) m6A 5'UTR       -
chr6:31367963-31367964(+) m6A 5'UTR       -
chr6:31368032-31368033(+) m6A 5'UTR       -
chr6:31368052-31368053(+) m6A 5'UTR       -
chr6:31368114-31368115(+) m6A 5'UTR       -
chr6:31378458-31378459(+) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr6:31378489-31378490(+) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr6:31378496-31378497(+) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr6:31378504-31378505(+) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr6:31378511-31378512(+) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr6:31378532-31378533(+) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr6:31378562-31378563(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr6:31378893-31378894(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085
chr6:31378953-31378954(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085
chr6:31378961-31378962(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085
chr6:31378973-31378974(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085
chr6:31379000-31379001(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085
chr6:31379048-31379049(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085
chr6:31379054-31379055(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085
chr6:31379079-31379080(+) m6A CDS//intron       24284625//24209618//25456834//24981863
chr6:31379092-31379093(+) m6A CDS//intron       24981863
chr6:31379132-31379133(+) m6A CDS//intron       -
chr6:31382916-31382917(+) m6A 3'UTR       24284625
chr6:31383005-31383006(+) m6A 3'UTR       24284625

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-372-3p
Exosome Serum     18589210
Exosome Brain tissue     23382797
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Nucleolus Cervical adenocarcinoma cells (HeLa)     24918059
MICA
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-372-3p
Interactor2: MICA

Evidence Support:


Strong-Evidence qRT-PCR
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 18677316 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line DU145 cells//HeLa cells Interactor2 expression Downregulation
Description To determine which of the predicted 3'UTR–binding human microRNAs were able to repress MICA and MICB expression, we expressed representatives of each family (miR-20a, miR-93, miR106b, miR-302d, miR-372, miR-373 and miR-520d) in HeLa and DU145 cells, which had high expression of MICA and MICB, respectively (Fig. 3a).

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