Detail Information

Basic Information:


  VIRBase ID:  

HHID00038518

  Virus:  

Human alphaherpesvirus 1 (HSV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.8589

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-373-3p:           SMOC1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-373-3p SMOC1
miRBase
Accession/Entrez ID		 MIMAT0000726 64093
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - OAS

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-373-3p
rs1216332469 chr19:53788767    G/A
rs1256684930 chr19:53788768    T/G
rs1295588996 chr19:53788763    TG/T
rs1306405430 chr19:53788766    G/T
rs1376453582 chr19:53788758    G/A
rs182623921 chr19:53788762    T/A
rs182623921 chr19:53788762    T/C
rs769766517 chr19:53788757    C/T
rs909973005 chr19:53788756    T/A
rs749244544 chr19:53788750    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SMOC1
chr14:70431933(+) A-I      intronic
chr14:70431908(+) A-I      intronic
chr14:70431839(+) A-I      intronic
chr14:70421106(+) A-I      intronic
chr14:70431893(+) A-I      intronic
chr14:70437839(+) A-I      intronic
chr14:70451480(+) A-I      intronic
chr14:70437784(+) A-I      intronic
chr14:70437786(+) A-I      intronic
chr14:70446372(+) A-I      intronic
chr14:70441940(+) A-I      intronic
chr14:70441939(+) A-I      intronic
chr14:70428175(+) A-I      intronic
chr14:70431301(+) A-I      intronic
chr14:70428328(+) A-I      intronic
chr14:70441851(+) A-I      intronic
chr14:70428335(+) A-I      intronic
chr14:70421154(+) A-I      intronic
chr14:70421160(+) A-I      intronic
chr14:70446358(+) A-I      intronic
chr14:70431306(+) A-I      intronic
chr14:70428265(+) A-I      intronic
chr14:70452927(+) A-I      intronic
chr14:70441832(+) A-I      intronic
chr14:70451305(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SMOC1
chr14:70352471(+) A-I intron -    22327324
chr14:70446358(+) A-I intron -    21960545

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SMOC1
chr14:70330881-70330882(+) m6A exon       24981863
chr14:70330889-70330890(+) m6A exon       24981863
chr14:70330900-70330901(+) m6A exon       24981863
chr14:70330919-70330920(+) m6A exon       24284625//24981863
chr14:70330926-70330927(+) m6A exon       24284625//24981863
chr14:70346274-70346275(+) m6A 5'UTR//intron       24284625//24209618//24981863//22575960
chr14:70346357-70346358(+) m6A 5'UTR//intron       24209618//22575960
chr14:70362384-70362385(+) Gm intron       -
chr14:70418902-70418903(+) m6A CDS//exon       22575960
chr14:70418913-70418914(+) m6A CDS//exon       22575960
chr14:70418981-70418982(+) m6A CDS//exon       22575960
chr14:70442515-70442516(+) m6A CDS//exon       22575960
chr14:70445240-70445241(+) Gm intron       -
chr14:70447402-70447403(+) Cm intron       -
chr14:70467904-70467905(+) Tm intron       -
chr14:70477629-70477630(+) m6A CDS//exon       22575960
chr14:70477652-70477653(+) m6A CDS//exon       22575960
chr14:70478241-70478242(+) m6A CDS//exon       22575960
chr14:70478269-70478270(+) m6A CDS//exon       22575960
chr14:70489933-70489934(+) m6A CDS       24284625//22575960
chr14:70489987-70489988(+) m6A CDS       24284625//22575960
chr14:70490104-70490105(+) m6A CDS       24284625//22575960
chr14:70490110-70490111(+) m6A CDS       24284625//22575960
chr14:70491419-70491420(+) Cm intron       -
chr14:70496985-70496986(+) m6A 3'UTR       24284625//22575960
chr14:70497031-70497032(+) m6A 3'UTR       24284625//22575960
chr14:70497152-70497153(+) m6A 3'UTR       24284625//24981863//22575960//22608085
chr14:70497197-70497198(+) m6A 3'UTR       24284625//24981863//22608085
chr14:70497883-70497884(+) Am 3'UTR       -
chr14:70498838-70498839(+) m6A 3'UTR       24284625//25456834//24981863
chr14:70498874-70498875(+) m6A 3'UTR       24284625//25456834//24981863
chr14:70498934-70498935(+) Y 3'UTR       26075521

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-373-3p
Exosome Cell lines (MCF10A|MCF-7|MDA-MB-231)     25446899
Exosome Primary ovarian tumor cells|Serum     18589210
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Serum     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
SMOC1
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Membrane HCC cell line (HepG2)     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-373-3p
10-Hydroxycamptothecin 97226 Drug interaction    RC00004164
Gemcitabine 60750 Drug interaction    RC00004163
Vorinostat 5311 Drug interaction    RC00004160
Eloxatine 5310940 Drug interaction    RC00004168
Diethylstilbestrol 448537 Drug interaction    RC00004167
Trichostatin A 444732 Drug interaction    RC00004166
Cyclopamine 442972 Drug interaction    RC00004165
Paclitaxel 36314 Drug interaction    RC00004162
5-Fluorouracil 3385 Drug interaction    RC00004159
Emodin 3220 Drug interaction    RC00004158
Doxorubicin 31703 Drug interaction    RC00004161
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00004157
Verapamil 2520 Drug interaction    RC00004156
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-373-3p
Gemcitabine 60750       30021382

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-373-3p
Interactor2: SMOC1

Evidence Support:


Strong-Evidence RT-PCR
Weak-Evidence MiRNA microarray
Support Database ViRBase

References:


PMID 29156530 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line HeLa cells Interactor2 expression Downregulation
Description MiR-373 negatively regulate IFN-I production and ISG expression.

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