Detail Information

Basic Information:


  VIRBase ID:  

HHID00038514

  Virus:  

Human alphaherpesvirus 1 (HSV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.9374

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-373-3p:           IFNB1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-373-3p IFNB1
miRBase
Accession/Entrez ID		 MIMAT0000726 3456
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IFB//IFF//IFN-beta//IFNB

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-373-3p
rs1216332469 chr19:53788767    G/A
rs1256684930 chr19:53788768    T/G
rs1295588996 chr19:53788763    TG/T
rs1306405430 chr19:53788766    G/T
rs1376453582 chr19:53788758    G/A
rs182623921 chr19:53788762    T/A
rs182623921 chr19:53788762    T/C
rs769766517 chr19:53788757    C/T
rs909973005 chr19:53788756    T/A
rs749244544 chr19:53788750    A/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IFNB1
chr9:21077198-21077199(-) m6A 3'UTR       27773535
chr9:21077273-21077274(-) m6A 3'UTR       27773535
chr9:21077278-21077279(-) m6A 3'UTR       27773535
chr9:21077308-21077309(-) m6A CDS       27773535
chr9:21077328-21077329(-) m6A CDS       27773535
chr9:21077347-21077348(-) m6A CDS       27773535
chr9:21077375-21077376(-) m6A CDS       27773535
chr9:21077592-21077593(-) m6A CDS       27773535
chr9:21077611-21077612(-) m6A CDS       27773535
chr9:21077695-21077696(-) m6A CDS       27773535
chr9:21077704-21077705(-) m6A CDS       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-373-3p
Exosome Cell lines (MCF10A|MCF-7|MDA-MB-231)     25446899
Exosome Primary ovarian tumor cells|Serum     18589210
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Serum     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-373-3p
10-Hydroxycamptothecin 97226 Drug interaction    RC00004164
Gemcitabine 60750 Drug interaction    RC00004163
Vorinostat 5311 Drug interaction    RC00004160
Eloxatine 5310940 Drug interaction    RC00004168
Diethylstilbestrol 448537 Drug interaction    RC00004167
Trichostatin A 444732 Drug interaction    RC00004166
Cyclopamine 442972 Drug interaction    RC00004165
Paclitaxel 36314 Drug interaction    RC00004162
5-Fluorouracil 3385 Drug interaction    RC00004159
Emodin 3220 Drug interaction    RC00004158
Doxorubicin 31703 Drug interaction    RC00004161
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00004157
Verapamil 2520 Drug interaction    RC00004156
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-373-3p
Gemcitabine 60750       30021382

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-373-3p
Interactor2: IFNB1

Evidence Support:


Strong-Evidence ELISA//RT-PCR
Weak-Evidence MiRNA microarray
Support Database ViRBase

References:


PMID 29156530 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line HeLa cells Interactor2 expression Downregulation
Description MiR-373 negatively regulate IFN-I production and ISG expression.

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