Basic Information:

  VIRBase ID:  

HHID00033939

  Virus:  

Gallid alphaherpesvirus 2

  Host:  

Gallus gallus

  Confidence Score:  

0.9945

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      gga-miR-21-5p:  MIMAT0003774          PDCD4:  NM_204304     

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Interactor Information:

	Interactor1	Interactor2
Symbol	gga-miR-21-5p	PDCD4
miRBase Accession/Entrez ID	MIMAT0003774	374191
Organism	Gallus gallus	Gallus gallus
Category	miRNA	mRNA
Alias	-	-

Interaction Network (The top 100 interactions):

Interactor1: gga-miR-21-5p
Interactor2: PDCD4

Evidence Support:

Strong-Evidence	5'-RACE//Luciferase reporter assay//qRT-PCR//RT-PCR//Western blot
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	23055556	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	DT-40 cells//JBJ-1 cells//MSB-1 cells//PA9 cells	Interactor2 expression	Downregulation
Description	GaHV-2 encodes a basic leucine zipper (bZIP) protein of the AP-1 family, Meq. We show here that the viral oncoprotein Meq binds to this promoter, thereby transactivating gga-miR-21 expression. We confirmed that this miRNA targets chicken programmed death cell 4(PDCD4) and promotes tumor cell growth and apoptosis escape.