Basic Information:

  VIRBase ID:  

HHID00027645

  Virus:  

Gallid alphaherpesvirus 2

  Host:  

Gallus gallus

  Confidence Score:  

0.9630

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      gga-miR-155:  MIMAT0001106          CEBPB:  NM_205253     

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Interactor Information:

	Interactor1	Interactor2
Symbol	gga-miR-155	CEBPB
miRBase Accession/Entrez ID	MIMAT0001106	396185
Organism	Gallus gallus	Gallus gallus
Category	miRNA	mRNA
Alias	-	NF-M

Interaction Network (The top 100 interactions):

Interactor1: gga-miR-155
Interactor2: CEBPB

Evidence Support:

Strong-Evidence	Luciferase reporter assay//Northern blot//Western blot
Prediction-Evidence	miRTarget2//Targetscan
Support Database	ViRBase

References:

[1]PMID	18945769	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	DF-1 cells	Interactor2 expression	Downregulation
Description	Thus, the reporter assays demonstrated that targets such as PU.1, CEBPE, HIVEP2, BCL2L13, and PDCD6 can be negatively regulated by both gga-miR-155 and MDV-1-miR-M4.

[2]PMID	20680360	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	DF-1 cells//MDCC-54-O cells//MDCC-MSB-1 cells	Interactor2 expression	None
Description	Using luciferase reporter assays, we showed that mdv1-miR-M4-5P and miR-155 efficiently targeted a common set of 3'untranslated regions (3'UTR) of six cellular genes (GPM6B, RREB1, c-Myb, MAP3K7IP2, PU.1[SPI1] and C/EBP).