Basic Information:

  VIRBase ID:  

HHID00026767

  Virus:  

Swine hepatitis E virus

  Host:  

Sus scrofa

  Confidence Score:  

0.9810

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      ssc-miR-221-3p:  MIMAT0007762          CDKN1B:  NM_214316     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ssc-miR-221-3p	CDKN1B
miRBase Accession/Entrez ID	MIMAT0007762	397584
Organism	Sus scrofa	Sus scrofa
Category	miRNA	mRNA
Alias	-	-

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ssc-miR-221-3p	Exosome Porcine milk     24499489

Interaction Network (The top 100 interactions):

Interactor1: ssc-miR-221-3p
Interactor2: CDKN1B

Evidence Support:

Strong-Evidence	Luciferase reporter assay//qRT-PCR//Western blot
Weak-Evidence	Microarray
Prediction-Evidence	miRanda//PicTar//Targetscan
Support Database	ViRBase

References:

PMID	23579640	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	This speculation is supported by our observation that after HEK293 cells were transfected with Pre-miR-221 or -222 and Anti-miR-221 or -222, SHEV ORF3-induced expression of p27kip1 mRNA and protein was blocked by Pre-miR-221 and -222, and was enhanced by Anti-miR-221 and -222, respectively (Fig.5 a, b, c).