Detail Information

Basic Information:


  VIRBase ID:  

HHID00026748

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9863

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548ah-3p:           HDAC4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-548ah-3p HDAC4
miRBase
Accession/Entrez ID		 MIMAT0020957 9759
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AHO3//BDMR//HA6116//HD4//HDAC-4//HDAC-A//HDACA

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-548ah-3p
rs1036377818 chr4:76575612    C/T
rs1486932451 chr4:76575608    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR HDAC4
chr2:240050161(-) A-I      intronic
chr2:240050142(-) A-I      intronic
chr2:240220780(-) A-I      intronic
chr2:240220794(-) A-I      intronic
chr2:240220816(-) A-I      intronic
chr2:240127977(-) A-I      intronic
chr2:240050139(-) A-I      intronic
chr2:240272305(-) A-I      intronic
chr2:240127832(-) A-I      intronic
chr2:240220806(-) A-I      intronic
chr2:240241965(-) A-I      intronic
chr2:240269370(-) A-I      intronic
chr2:240269388(-) A-I      intronic
chr2:240269404(-) A-I      intronic
chr2:240127884(-) A-I      intronic
chr2:240127779(-) A-I      intronic
chr2:240220789(-) A-I      intronic
chr2:240272398(-) A-I      intronic
chr2:239977366(-) A-I      intronic
chr2:239977369(-) A-I      intronic
chr2:239977399(-) A-I      intronic
chr2:240049964(-) A-I      intronic
chr2:240050125(-) A-I      intronic
chr2:240050138(-) A-I      intronic
chr2:240306200(-) A-I      intronic
chr2:240306190(-) A-I      intronic
chr2:240306092(-) A-I      intronic
chr2:240269377(-) A-I      intronic
chr2:240289457(-) A-I      intronic
chr2:240269483(-) A-I      intronic
chr2:240267158(-) A-I      intronic
chr2:240267052(-) A-I      intronic
chr2:240295366(-) A-I      intronic
chr2:240304426(-) A-I      intronic
chr2:240267241(-) A-I      intronic
chr2:240269348(-) A-I      intronic
chr2:240050217(-) A-I      intronic
chr2:240119665(-) A-I      intronic
chr2:240011164(-) A-I      intronic
chr2:240267163(-) A-I      intronic
chr2:240269325(-) A-I      intronic
chr2:240220702(-) A-I      intronic
chr2:240269490(-) A-I      intronic
chr2:240050113(-) A-I      intronic
chr2:240295337(-) A-I      intronic
chr2:240269389(-) A-I      intronic
chr2:240267040(-) A-I      intronic
chr2:240269374(-) A-I      intronic
chr2:240100143(-) A-I      intronic
chr2:240011161(-) A-I      intronic
chr2:240050221(-) A-I      intronic
chr2:239977165(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED HDAC4
chr2:240269321(-) A-I intron -    15342557
chr2:240269325(-) A-I intron -    15342557
chr2:240269374(-) A-I intron -    15342557
chr2:240269377(-) A-I intron -    15342557
chr2:240269638(-) A-I intron -    15342557
chr2:240269751(-) A-I intron -    15342557
chr2:240050217(-) A-G intron -    22484847
chr2:240121629(-) A-C intron -    22484847
chr2:240269377(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase HDAC4
chr2:239970875-239970876(-) m6A 3'UTR       24981863
chr2:239970884-239970885(-) m6A 3'UTR       24981863
chr2:239970932-239970933(-) m6A 3'UTR       24981863
chr2:239974022-239974023(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr2:239974044-239974045(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr2:239974062-239974063(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr2:239974185-239974186(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr2:239974191-239974192(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr2:239974196-239974197(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr2:239974201-239974202(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr2:239974214-239974215(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr2:239974222-239974223(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr2:239974264-239974265(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr2:239974337-239974338(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085
chr2:239974384-239974385(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085
chr2:239974399-239974400(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085
chr2:239974427-239974428(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr2:239974541-239974542(-) m6A 3'UTR       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr2:239974549-239974550(-) m6A 3'UTR       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr2:239974570-239974571(-) m6A 3'UTR       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr2:239974577-239974578(-) m6A 3'UTR       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr2:239974675-239974676(-) m6A 3'UTR       24284625//25456834//24981863//27371828//27773536//22575960
chr2:239974730-239974731(-) m6A 3'UTR       24284625//24981863//27371828
chr2:240016211-240016212(-) m6A intron       24284625//22575960
chr2:240033364-240033365(-) m6A CDS//exon       27371828
chr2:240036751-240036752(-) m6A CDS//exon       27371828
chr2:240036899-240036900(-) m6A CDS//exon       24981863//27371828//27773536
chr2:240048155-240048156(-) m6A CDS//exon       -
chr2:240048193-240048194(-) m6A CDS//exon       -
chr2:240048329-240048330(-) m6A CDS//exon       24284625
chr2:240056109-240056110(-) m6A CDS//exon       24284625
chr2:240056321-240056322(-) m6A CDS//exon       24284625
chr2:240061460-240061461(-) m6A CDS//exon       24284625
chr2:240098128-240098129(-) m6A CDS//exon       24981863//27371828//27773536
chr2:240098211-240098212(-) m6A CDS//exon       24284625//24981863//27371828//27773536
chr2:240108276-240108277(-) m6A exon//intron       27371828
chr2:240108284-240108285(-) m6A exon//intron       27371828
chr2:240111706-240111707(-) m6A 5'UTR//CDS//exon       27371828//27773536
chr2:240111718-240111719(-) m6A 5'UTR//CDS//exon       27371828//27773536
chr2:240259314-240259315(-) Gm intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-548ah-3p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
HDAC4
Chromatin HCC cell line (HepG2)|K562 cells     -
Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-548ah-3p
Interactor2: HDAC4

Evidence Support:


Strong-Evidence ChIP//Dual luciferase reporter assay//qPCR//Western blot
Prediction-Evidence miRanda//miRDB//Targetscan
Support Database ViRBase

References:


PMID 30615846 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line HepG2 cells//HepG2.2.15 cells//Huh-7 cells Interactor2 expression None
Description We identified three binding sites of miRNA-548ah in the HDAC4 gene sequence (Supplemental Fig. 3).

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