Detail Information

Basic Information:


  VIRBase ID:  

HHID00026745

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3613-3p:           IFNB1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-3613-3p IFNB1
miRBase
Accession/Entrez ID		 MIMAT0017991 3456
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IFB//IFF//IFN-beta//IFNB

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-3613-3p
rs1183223132 chr13:49996436    G/C
rs1250356253 chr13:49996429    G/A
rs1335741479 chr13:49996439    T/A
rs1388012182 chr13:49996426    G/C
rs1461704999 chr13:49996430    G/T
rs546312437 chr13:49996433    T/C
rs745846959 chr13:49996432    T/A
rs745846959 chr13:49996432    T/C
rs770351330 chr13:49996437    CTTTT/C
rs770351330 chr13:49996437    CTTTT/CTTT
rs770351330 chr13:49996437    CTTTT/CTTTTT
rs932187323 chr13:49996431    G/A
rs932187323 chr13:49996431    G/C
rs1288676820 chr13:49996444    T/C
rs1488871943 chr13:49996448    G/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IFNB1
chr9:21077198-21077199(-) m6A 3'UTR       27773535
chr9:21077273-21077274(-) m6A 3'UTR       27773535
chr9:21077278-21077279(-) m6A 3'UTR       27773535
chr9:21077308-21077309(-) m6A CDS       27773535
chr9:21077328-21077329(-) m6A CDS       27773535
chr9:21077347-21077348(-) m6A CDS       27773535
chr9:21077375-21077376(-) m6A CDS       27773535
chr9:21077592-21077593(-) m6A CDS       27773535
chr9:21077611-21077612(-) m6A CDS       27773535
chr9:21077695-21077696(-) m6A CDS       27773535
chr9:21077704-21077705(-) m6A CDS       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-3613-3p
Exosome Pooled sera     27278097
Exosome Plasma     23663360
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-3613-3p
Interactor2: IFNB1

Evidence Support:


Strong-Evidence ELISA//qPCR
Support Database ViRBase

References:


PMID 31201869 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line Huh-7 cells Interactor2 expression None
Description Inhibition of miR-3613-3p decreased relative expressions of IFN-alpha and IFN-beta, HBV DNA copies, and increased the hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) levels, whereas miR-3613-3p overexpression reversed these changes in vitro and in vivo.

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