Basic Information:

  VIRBase ID:  

HHID00026732

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9612

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-200c-5p:  MIMAT0004657          NFIA:  NM_001134673     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-200c-5p	NFIA
miRBase Accession/Entrez ID	MIMAT0004657	4774
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BRMUTD//CTF//NF-I/A//NF1-A//NFI-A//NFI-L

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-200c-5p	rs1220589670 chr12:6963703    C/T rs1277597787 chr12:6963716    A/C rs372372905 chr12:6963719    G/A rs942672545 chr12:6963713    A/G rs1318673559 chr12:6963704    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NFIA	chr1:61594124(+) A-I      intronic chr1:61594132(+) A-I      intronic chr1:61594149(+) A-I      intronic chr1:61655151(+) A-I      intronic chr1:61655159(+) A-I      intronic chr1:61655161(+) A-I      intronic chr1:61655184(+) A-I      intronic chr1:61655198(+) A-I      intronic chr1:61579106(+) A-I      intronic chr1:61592866(+) A-I      intronic chr1:61592913(+) A-I      intronic chr1:61592967(+) A-I      intronic chr1:61594215(+) A-I      intronic chr1:61595263(+) A-I      intronic chr1:61620834(+) A-I      intronic chr1:61603885(+) A-I      intronic chr1:61603893(+) A-I      intronic chr1:61603907(+) A-I      intronic chr1:61603915(+) A-I      intronic chr1:61603957(+) A-I      intronic chr1:61620017(+) A-I      intronic chr1:61620146(+) A-I      intronic chr1:61639262(+) A-I      intronic chr1:61663434(+) A-I      intronic chr1:61675463(+) A-I      intronic chr1:61675468(+) A-I      intronic chr1:61677444(+) A-I      intronic chr1:61677450(+) A-I      intronic chr1:61677495(+) A-I      intronic chr1:61816218(+) A-I      intronic chr1:61856940(+) A-I      intronic chr1:61645474(+) A-I      intronic chr1:61579103(+) A-I      intronic chr1:61579087(+) A-I      intronic chr1:61579104(+) A-I      intronic chr1:61579107(+) A-I      intronic chr1:61579112(+) A-I      intronic chr1:61592550(+) A-I      intronic chr1:61594097(+) A-I      intronic chr1:61594101(+) A-I      intronic chr1:61594105(+) A-I      intronic chr1:61594106(+) A-I      intronic chr1:61862553(+) A-I      intronic chr1:61862523(+) A-I      intronic chr1:61862521(+) A-I      intronic chr1:61862171(+) A-I      intronic chr1:61862139(+) A-I      intronic chr1:61854711(+) A-I      intronic chr1:61854706(+) A-I      intronic chr1:61854688(+) A-I      intronic chr1:61675403(+) A-I      intronic chr1:61775379(+) A-I      intronic chr1:61665390(+) A-I      intronic chr1:61665389(+) A-I      intronic chr1:61663091(+) A-I      intronic chr1:61658254(+) A-I      intronic chr1:61658149(+) A-I      intronic chr1:61775375(+) A-I      intronic chr1:61657706(+) A-I      intronic chr1:61655190(+) A-I      intronic chr1:61653759(+) A-I      intronic chr1:61621788(+) A-I      intronic chr1:61621747(+) A-I      intronic chr1:61775374(+) A-I      intronic chr1:61775371(+) A-I      intronic chr1:61722058(+) A-I      intronic chr1:61722057(+) A-I      intronic chr1:61722038(+) A-I      intronic chr1:61722001(+) A-I      intronic chr1:61721997(+) A-I      intronic chr1:61721987(+) A-I      intronic chr1:61685158(+) A-I      intronic chr1:61685145(+) A-I      intronic chr1:61677569(+) A-I      intronic chr1:61621334(+) A-I      intronic chr1:61600461(+) A-I      intronic chr1:61600460(+) A-I      intronic chr1:61600429(+) A-I      intronic chr1:61595384(+) A-I      intronic chr1:61595383(+) A-I      intronic chr1:61595357(+) A-I      intronic chr1:61595330(+) A-I      intronic chr1:61595318(+) A-I      intronic chr1:61595215(+) A-I      intronic chr1:61595196(+) A-I      intronic chr1:61594674(+) A-I      intronic chr1:61593018(+) A-I      intronic chr1:61593006(+) A-I      intronic chr1:61593002(+) A-I      intronic chr1:61592674(+) A-I      intronic chr1:61592593(+) A-I      intronic chr1:61592574(+) A-I      intronic chr1:61592564(+) A-I      intronic chr1:61583718(+) A-I      intronic chr1:61583660(+) A-I      intronic chr1:61583655(+) A-I      intronic chr1:61580019(+) A-I      intronic chr1:61566839(+) A-I      intronic chr1:61566469(+) A-I      intronic chr1:61561947(+) A-I      intronic chr1:61850858(+) A-I      intronic chr1:61658096(+) A-I      intronic chr1:61603821(+) A-I      intronic chr1:61621091(+) A-I      intronic chr1:61594620(+) A-I      intronic chr1:61658210(+) A-I      intronic chr1:61621761(+) A-I      intronic chr1:61604284(+) A-I      intronic chr1:61657837(+) A-I      intronic chr1:61592598(+) A-I      intronic chr1:61850918(+) A-I      intronic chr1:61753221(+) A-I      intronic chr1:61663120(+) A-I      intronic chr1:61594793(+) A-I      intronic chr1:61663040(+) A-I      intronic chr1:61594734(+) A-I      intronic chr1:61621645(+) A-I      intronic chr1:61675377(+) A-I      intronic chr1:61816124(+) A-I      intronic chr1:61592645(+) A-I      intronic chr1:61655272(+) A-I      intronic chr1:61657701(+) A-I      intronic chr1:61663399(+) A-I      intronic chr1:61677498(+) A-I      intronic chr1:61566377(+) A-I      intronic chr1:61663011(+) A-I      intronic chr1:61754592(+) A-I      intronic chr1:61724525(+) A-I      intronic chr1:61491703(+) A-I      intronic chr1:61594801(+) A-I      intronic chr1:61663542(+) A-I      intronic chr1:61778459(+) A-I      intronic chr1:61580753(+) A-I      intronic chr1:61604489(+) A-I      intronic chr1:61451843(+) A-I      intronic chr1:61566456(+) A-I      intronic chr1:61619841(+) A-I      intronic chr1:61723114(+) A-I      intronic chr1:61594675(+) A-I      intronic chr1:61663503(+) A-I      intronic chr1:61594068(+) A-I      intronic chr1:61592586(+) A-I      intronic chr1:61861935(+) A-I      intronic chr1:61639324(+) A-I      intronic chr1:61583600(+) A-I      intronic chr1:61566988(+) A-I      intronic chr1:61566515(+) A-I      intronic chr1:61640956(+) A-I      intronic chr1:61595226(+) A-I      intronic chr1:61592630(+) A-I      intronic chr1:61463625(+) A-I      intronic chr1:61640953(+) A-I      intronic chr1:61675385(+) A-I      intronic chr1:61640837(+) A-I      intronic chr1:61816263(+) A-I      intronic chr1:61489039(+) A-I      intronic chr1:61566891(+) A-I      intronic chr1:61723139(+) A-I      intronic chr1:61451840(+) A-I      intronic chr1:61566320(+) A-I      intronic chr1:61595374(+) A-I      intronic chr1:61658211(+) A-I      intronic chr1:61594760(+) A-I      intronic chr1:61754704(+) A-I      intronic chr1:61621663(+) A-I      intronic chr1:61700880(+) A-I      intronic chr1:61594699(+) A-I      intronic chr1:61600422(+) A-I      intronic chr1:61726459(+) A-I      intronic chr1:61594854(+) A-I      intronic chr1:61682486(+) A-I      intronic chr1:61663186(+) A-I      intronic chr1:61616902(+) A-I      intronic chr1:61489115(+) A-I      intronic chr1:61593136(+) A-I      intronic chr1:61490562(+) A-I      intronic chr1:61594776(+) A-I      intronic chr1:61594196(+) A-I      intronic chr1:61658185(+) A-I      intronic chr1:61726513(+) A-I      intronic chr1:61594736(+) A-I      intronic chr1:61580868(+) A-I      intronic chr1:61451859(+) A-I      intronic chr1:61859949(+) A-I      intronic chr1:61580752(+) A-I      intronic chr1:61344648(+) A-I      intronic chr1:61592782(+) A-I      intronic chr1:61343930(+) A-I      intronic chr1:61723293(+) A-I      intronic chr1:61488943(+) A-I      intronic chr1:61776806(+) A-I      intronic chr1:61580781(+) A-I      intronic chr1:61594856(+) A-I      intronic chr1:61580148(+) A-I      intronic chr1:61594868(+) A-I      intronic chr1:61604838(+) A-I      intronic chr1:61451782(+) A-I      intronic chr1:61451794(+) A-I      intronic chr1:61775568(+) A-I      intronic chr1:61658186(+) A-I      intronic chr1:61619853(+) A-I      intronic chr1:61658228(+) A-I      intronic chr1:61490162(+) A-I      intronic chr1:61677394(+) A-I      intronic chr1:61593050(+) A-I      intronic chr1:61463588(+) A-I      intronic chr1:61594186(+) A-I      intronic chr1:61489106(+) A-I      intronic chr1:61658268(+) A-I      intronic chr1:61604488(+) A-I      intronic chr1:61566382(+) A-I      intronic chr1:61592752(+) A-I      intronic chr1:61593873(+) A-I      intronic chr1:61492241(+) A-I      intronic chr1:61580140(+) A-I      intronic chr1:61580141(+) A-I      intronic chr1:61723113(+) A-I      intronic chr1:61561966(+) A-I      intronic chr1:61566978(+) A-I      intronic chr1:61489038(+) A-I      intronic chr1:61653901(+) A-I      intronic chr1:61682487(+) A-I      intronic chr1:61721845(+) A-I      intronic chr1:61594128(+) A-I      intronic chr1:61813052(+) A-I      intronic chr1:61463596(+) A-I      intronic chr1:61604799(+) A-I      intronic chr1:61488649(+) A-I      intronic chr1:61595301(+) A-I      intronic chr1:61850896(+) A-I      intronic chr1:61604830(+) A-I      intronic chr1:61583691(+) A-I      intronic chr1:61592665(+) A-I      intronic chr1:61595222(+) A-I      intronic chr1:61488894(+) A-I      intronic chr1:61641014(+) A-I      intronic chr1:61791507(+) A-I      intronic chr1:61732306(+) A-I      intronic chr1:61580683(+) A-I      intronic chr1:61580041(+) A-I      intronic chr1:61579200(+) A-I      intronic chr1:61663152(+) A-I      intronic chr1:61594690(+) A-I      intronic chr1:61594688(+) A-I      intronic chr1:61566315(+) A-I      intronic chr1:61699985(+) A-I      intronic chr1:61640891(+) A-I      intronic chr1:61620089(+) A-I      intronic chr1:61662991(+) A-I      intronic chr1:61641088(+) A-I      intronic chr1:61658325(+) A-I      intronic chr1:61580949(+) A-I      intronic chr1:61579223(+) A-I      intronic chr1:61594770(+) A-I      intronic chr1:61677578(+) A-I      intronic chr1:61593008(+) A-I      intronic chr1:61579208(+) A-I      intronic chr1:61490110(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NFIA	chr1:61592380(+) A-I intron -    15342557 chr1:61593873(+) A-I intron -    15342557 chr1:61594620(+) A-I intron -    15342557 chr1:61594675(+) A-I intron -    15342557 chr1:61594688(+) A-I intron -    15342557 chr1:61594690(+) A-I intron -    15342557 chr1:61594699(+) A-I intron -    15342557 chr1:61594734(+) A-I intron -    15342557 chr1:61594736(+) A-I intron -    15342557 chr1:61594760(+) A-I intron -    15342557 chr1:61594770(+) A-I intron -    15342557 chr1:61594776(+) A-I intron -    15342557 chr1:61594793(+) A-I intron -    15342557 chr1:61595222(+) A-I intron -    15342557 chr1:61566315(+) A-I intron -    21960545 chr1:61566320(+) A-I intron -    21960545 chr1:61566377(+) A-I intron -    21960545 chr1:61566382(+) A-I intron -    21960545 chr1:61566476(+) A-I intron -    21960545 chr1:61580019(+) A-I intron -    21960545 chr1:61580112(+) A-I intron -    21960545 chr1:61580683(+) A-I intron -    21960545 chr1:61580752(+) A-I intron -    21960545 chr1:61580753(+) A-I intron -    21960545 chr1:61583627(+) A-I intron -    21960545 chr1:61594029(+) A-I intron -    21960545 chr1:61594196(+) A-I intron -    21960545 chr1:61600461(+) A-I intron -    21960545 chr1:61601177(+) A-I intron -    21960545 chr1:61601181(+) A-I intron -    21960545 chr1:61601202(+) A-I intron -    21960545 chr1:61601299(+) A-I intron -    21960545 chr1:61601313(+) A-I intron -    21960545 chr1:61601314(+) A-I intron -    21960545 chr1:61603821(+) A-I intron -    21960545 chr1:61603885(+) A-I intron -    21960545 chr1:61604284(+) A-I intron -    21960545 chr1:61640837(+) A-I intron -    21960545 chr1:61640845(+) A-I intron -    21960545 chr1:61640953(+) A-I intron -    21960545 chr1:61640956(+) A-I intron -    21960545 chr1:61644493(+) A-I intron -    21960545 chr1:61645569(+) A-I intron -    21960545 chr1:61677444(+) A-I intron -    21960545 chr1:61778387(+) A-I intron -    21960545 chr1:61854639(+) A-I intron -    21960545 chr1:61726459(+) A-G intron -    22484847 chr1:61726486(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NFIA	chr1:61548223-61548224(+) m6A 5'UTR//intron       24981863 chr1:61548419-61548420(+) m6A 5'UTR//intron       24284625//24981863 chr1:61553921-61553922(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863//22608085 chr1:61553984-61553985(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr1:61554089-61554090(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr1:61554118-61554119(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr1:61554181-61554182(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr1:61554314-61554315(+) m6A CDS//intron       24284625//24981863//22575960//22608085 chr1:61606869-61606870(+) Am intron       - chr1:61638914-61638915(+) Cm intron       - chr1:61848976-61848977(+) m6A CDS//exon//intron       - chr1:61849029-61849030(+) m6A CDS//exon//intron       - chr1:61869935-61869936(+) m6A CDS//exon       24284625 chr1:61872342-61872343(+) m6A CDS//exon       24284625 chr1:61892166-61892167(+) m6A CDS//intron       24284625 chr1:61892185-61892186(+) m6A CDS//intron       24284625 chr1:61892222-61892223(+) m6A CDS//intron       24284625 chr1:61905154-61905155(+) m6A CDS//intron       24284625 chr1:61905180-61905181(+) m6A CDS//intron       24284625//22608085 chr1:61921019-61921020(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr1:61921111-61921112(+) m6A 3'UTR       24284625//24981863//22608085 chr1:61921139-61921140(+) m6A 3'UTR       24284625//24981863//22608085 chr1:61921159-61921160(+) m6A 3'UTR       24284625//24981863//22608085 chr1:61921212-61921213(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr1:61921313-61921314(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr1:61921440-61921441(+) m6A 3'UTR       24284625//24981863 chr1:61921483-61921484(+) m6A 3'UTR       24284625//24981863 chr1:61922370-61922371(+) m6A 3'UTR       24981863 chr1:61922476-61922477(+) m6A 3'UTR       24981863//27773535 chr1:61922483-61922484(+) m6A 3'UTR       24981863//27773535 chr1:61922489-61922490(+) m6A 3'UTR       24981863//27773535 chr1:61922500-61922501(+) m6A 3'UTR       24981863//27773535 chr1:61922509-61922510(+) m6A 3'UTR       24981863 chr1:61922518-61922519(+) m6A 3'UTR       24981863 chr1:61922524-61922525(+) m6A 3'UTR       24981863 chr1:61922556-61922557(+) m6A 3'UTR       24981863 chr1:61926789-61926790(+) m6A 3'UTR       24284625//24981863//22608085 chr1:61926803-61926804(+) m6A 3'UTR       24284625//24981863//22608085 chr1:61926814-61926815(+) m6A 3'UTR       24284625//24981863//22608085 chr1:61926867-61926868(+) m6A 3'UTR       24284625//24981863//22608085 chr1:61926888-61926889(+) m6A 3'UTR       24981863//22608085 chr1:61926934-61926935(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-200c-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	NFIA	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm HCC cell line (HepG2)|K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-200c-5p
Interactor2: NFIA

Evidence Support:

Strong-Evidence	Dual luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	29710475	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	293T cells//HepG2.2.15 cells//Huh-7 cells	Interactor2 expression	Upregulation
Description	The result showed that there were some presumptive miR-200c binding sites in 3'UTR of NFIA mRNA.