Basic Information:

  VIRBase ID:  

HHID00026729

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-146a-3p:  MIMAT0004608          FEN1:  NM_004111     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-146a-3p	FEN1
miRBase Accession/Entrez ID	MIMAT0004608	2237
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	FEN-1//MF1//RAD2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-146a-3p	rs1323710653 chr5:160485408    C/T rs1343966428 chr5:160485421    G/C rs529455292 chr5:160485429    G/T rs772931224 chr5:160485420    A/G rs1173033188 chr5:160485411    CT/C rs1234876154 chr5:160485413    G/GA rs2910164 chr5:160485411    C/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FEN1	chr11:61561675(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FEN1	chr11:61560143-61560144(+) m6A 5'UTR       24981863 chr11:61560192-61560193(+) m6A 5'UTR       25456834//24981863 chr11:61560214-61560215(+) m6A 5'UTR       25456834//24981863 chr11:61560252-61560253(+) m6A 5'UTR       25456834//24981863 chr11:61560272-61560273(+) m6A 5'UTR       25456834 chr11:61560435-61560436(+) m6A 5'UTR       24284625//25456834//24981863//22575960 chr11:61560459-61560460(+) m6A 5'UTR       24284625//25456834//24981863//22575960 chr11:61560505-61560506(+) m6A 5'UTR//intron       24284625//25456834//24981863//22575960 chr11:61561284-61561285(+) Am intron       - chr11:61562856-61562857(+) m6A CDS       24284625//24981863 chr11:61563010-61563011(+) m6A CDS       24284625//22575960 chr11:61563258-61563259(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:61563368-61563369(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:61563374-61563375(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:61563488-61563489(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:61563495-61563496(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:61563575-61563576(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:61563583-61563584(+) Cm CDS       - chr11:61563687-61563688(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:61563701-61563702(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:61563909-61563910(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr11:61563940-61563941(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:61564051-61564052(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr11:61564198-61564199(+) m6A 3'UTR//intron       24209618//24981863//27773535//22608085 chr11:61564222-61564223(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085 chr11:61564299-61564300(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:61564363-61564364(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:61564369-61564370(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:61564450-61564451(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:61564545-61564546(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:61564551-61564552(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:61564627-61564628(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:61564640-61564641(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-146a-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	FEN1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-146a-3p
Interactor2: FEN1

Evidence Support:

Strong-Evidence	qRT-PCR//Western blot
Support Database	ViRBase

References:

PMID	32659369	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	HepG2.2.15 cells	Interactor2 expression	Upregulation
Description	MiR-146a promotes FEN1 expression//The expression of FEN1 was detected after the transfection of miR-146a mimic and inhibitor into HepG2.2.15 cells by qRT-PCR and Western blot.