Basic Information:
VIRBase ID: HHID00026726
Virus: Hepatitis B virus (HBV)
Host: Homo sapiens
Confidence Score: 0.8808
Interaction Type: Host-Host interaction
Predicted Binding:
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Interactor Information:
Interactor1
Interactor2
Symbol
hsa-miR-122-3p
TP53
miRBase Accession/Entrez ID
MIMAT0004590
7157
Organism
Homo sapiens
Homo sapiens
Category
miRNA
mRNA
Alias
-
BCC7//BMFS5//LFS1//P53//TRP53
ncRNA SNP information:
Resource
Symbol
SNP ID
SNP Position
Ref/Alt
miRNASNP-v3
hsa-miR-122-3p
RNA Editing:
Resource
Symbol
Editing Position
Lncediting
TP53
Resource
Symbol
Editing Position
Change
Genetic Region
RADAR
TP53
Resource
Symbol
Editing Position
Change
SeqReg
exReg
PMID
DARNED
TP53
RNA Modification:
Resource
Symbol
ModificationPosition
Type
Genomic Context
PMID
RMBase
TP53
RNA Localization:
Resource
Symbol
Subcellular Localization
Tissue or Cell Line
PMID
RNALocate
hsa-miR-122-3p
TP53
Interaction Network (The top 100 interactions) :
Interactor1: hsa-miR-122-3p
Interactor2: TP53
Evidence Support:
Strong-Evidence
RT-qPCR//Western blot
Support Database
ViRBase
References:
PMID
31366735
Target region
None
Source
ViRBase
Interactor1 expression
None
Tissue or cell line
Huh7 cells
Interactor2 expression
None
Description
In addition, our findings suggest that ADAR1 adopts the cyclin G1 and p53 proteins as downstream molecules of miR122 to reduce the HBV RNA levels. As expected, the ADAR1- and miR-122 mimic transfectants showed decreased cyclin G1 expression with concomitant up-regulation of the p53 protein (Fig. 6A).