Basic Information:

  VIRBase ID:  

HHID00026707

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8589

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-26a-1-3p:  MIMAT0004499          IL10:  NR_168467     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-26a-1-3p	IL10
miRBase Accession/Entrez ID	MIMAT0004499	3586
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CSIF//GVHDS//IL-10//IL10A//TGIF

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-26a-1-3p	rs182070256 chr3:37969473    G/A rs771522629 chr3:37969472    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IL10	chr1:206941331(-) A-I      3'UTR

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-26a-1-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849
	IL10	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-26a-1-3p
Interactor2: IL10

Evidence Support:

Strong-Evidence	RT-PCR
Weak-Evidence	Microarray
Support Database	VIRmiRNA

References:

PMID	19812400	Target region	None
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	Hepatocytes cells	Interactor2 expression	None
Description	To validate which genes were associated with this signaling pathway, we measured the level of the NF-kaapaB target gene, IL6 by qRT-PCR, since it was also related to hepatocellular carcinoma and the disparity in miR-26 expression levels between the sexes. Most of the patients with hepatocellular carcinoma who had reduced miR-26 expression had a concomitant elevation in interleukin-6 expression (Fig. 4 in the Supplementary Appendix).