Basic Information:

  VIRBase ID:  

HHID00026706

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7f-2-3p:  MIMAT0004487          RAB40C:  NM_021168     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7f-2-3p	RAB40C
miRBase Accession/Entrez ID	MIMAT0004487	57799
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	RARL//RASL8C

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7f-2-3p	rs1556935827 chrX:53557203    C/G rs1556935837 chrX:53557205    G/A rs782106021 chrX:53557206    T/C rs781874809 chrX:53557216    A/G rs782760005 chrX:53557211    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RAB40C	chr16:652355(+) A-I      intronic chr16:652359(+) A-I      intronic chr16:652381(+) A-I      intronic chr16:651999(+) A-I      intronic chr16:651916(+) A-I      intronic chr16:651816(+) A-I      intronic chr16:650644(+) A-I      intronic chr16:650589(+) A-I      intronic chr16:650564(+) A-I      intronic chr16:650503(+) A-I      intronic chr16:650489(+) A-I      intronic chr16:648582(+) A-I      intronic chr16:648570(+) A-I      intronic chr16:652776(+) A-I      intronic chr16:665783(+) A-I      intronic chr16:665786(+) A-I      intronic chr16:666091(+) A-I      intronic chr16:666094(+) A-I      intronic chr16:666102(+) A-I      intronic chr16:652676(+) A-I      intronic chr16:652347(+) A-I      intronic chr16:648447(+) A-I      intronic chr16:666118(+) A-I      intronic chr16:666505(+) A-I      intronic chr16:652400(+) A-I      intronic chr16:668453(+) A-I      intronic chr16:652642(+) A-I      intronic chr16:672558(+) A-I      intronic chr16:673494(+) A-I      intronic chr16:673496(+) A-I      intronic chr16:673563(+) A-I      intronic chr16:673765(+) A-I      intronic chr16:673807(+) A-I      intronic chr16:673835(+) A-I      intronic chr16:652372(+) A-I      intronic chr16:648405(+) A-I      intronic chr16:666106(+) A-I      intronic chr16:652028(+) A-I      intronic chr16:652019(+) A-I      intronic chr16:652015(+) A-I      intronic chr16:652011(+) A-I      intronic chr16:648202(+) A-I      intronic chr16:648151(+) A-I      intronic chr16:648130(+) A-I      intronic chr16:648125(+) A-I      intronic chr16:648124(+) A-I      intronic chr16:648106(+) A-I      intronic chr16:648094(+) A-I      intronic chr16:648086(+) A-I      intronic chr16:648083(+) A-I      intronic chr16:648069(+) A-I      intronic chr16:648059(+) A-I      intronic chr16:648036(+) A-I      intronic chr16:647919(+) A-I      intronic chr16:647644(+) A-I      intronic chr16:647636(+) A-I      intronic chr16:644900(+) A-I      intronic chr16:652032(+) A-I      intronic chr16:657448(+) A-I      intronic chr16:665756(+) A-I      intronic chr16:653009(+) A-I      intronic chr16:650604(+) A-I      intronic chr16:648595(+) A-I      intronic chr16:648215(+) A-I      intronic chr16:652033(+) A-I      intronic chr16:648450(+) A-I      intronic chr16:647891(+) A-I      intronic chr16:670314(+) A-I      intronic chr16:654964(+) A-I      intronic chr16:673641(+) A-I      intronic chr16:670318(+) A-I      intronic chr16:641857(+) A-I      intronic chr16:647751(+) A-I      intronic chr16:668464(+) A-I      intronic chr16:647764(+) A-I      intronic chr16:648621(+) A-I      intronic chr16:652831(+) A-I      intronic chr16:648440(+) A-I      intronic chr16:654902(+) A-I      intronic chr16:655131(+) A-I      intronic chr16:652707(+) A-I      intronic chr16:651783(+) A-I      intronic chr16:647728(+) A-I      intronic chr16:658752(+) A-I      intronic chr16:647845(+) A-I      intronic chr16:647591(+) A-I      intronic chr16:672551(+) A-I      intronic chr16:652006(+) A-I      intronic chr16:654804(+) A-I      intronic chr16:657426(+) A-I      intronic chr16:654874(+) A-I      intronic chr16:673462(+) A-I      intronic chr16:652695(+) A-I      intronic chr16:658968(+) A-I      intronic chr16:651718(+) A-I      intronic chr16:668519(+) A-I      intronic chr16:652805(+) A-I      intronic chr16:654898(+) A-I      intronic chr16:666443(+) A-I      intronic chr16:651930(+) A-I      intronic chr16:672647(+) A-I      intronic chr16:647727(+) A-I      intronic chr16:647839(+) A-I      intronic chr16:654194(+) A-I      intronic chr16:659040(+) A-I      intronic chr16:654850(+) A-I      intronic chr16:666080(+) A-I      intronic chr16:647616(+) A-I      intronic chr16:652389(+) A-I      intronic chr16:666419(+) A-I      intronic chr16:665688(+) A-I      intronic chr16:652396(+) A-I      intronic chr16:655114(+) A-I      intronic chr16:652558(+) A-I      intronic chr16:650640(+) A-I      intronic chr16:648287(+) A-I      intronic chr16:647626(+) A-I      intronic chr16:648217(+) A-I      intronic chr16:673547(+) A-I      intronic chr16:672706(+) A-I      intronic chr16:657641(+) A-I      intronic chr16:652005(+) A-I      intronic chr16:673447(+) A-I      intronic chr16:652630(+) A-I      intronic chr16:648298(+) A-I      intronic chr16:668469(+) A-I      intronic chr16:647507(+) A-I      intronic chr16:665841(+) A-I      intronic chr16:665752(+) A-I      intronic chr16:653001(+) A-I      intronic chr16:651742(+) A-I      intronic chr16:672703(+) A-I      intronic chr16:647770(+) A-I      intronic chr16:641869(+) A-I      intronic chr16:655104(+) A-I      intronic chr16:647586(+) A-I      intronic chr16:647503(+) A-I      intronic chr16:645658(+) A-I      intronic chr16:673829(+) A-I      intronic chr16:650740(+) A-I      intronic chr16:657277(+) A-I      intronic chr16:672667(+) A-I      intronic chr16:647679(+) A-I      intronic chr16:653064(+) A-I      intronic chr16:647741(+) A-I      intronic chr16:657247(+) A-I      intronic chr16:647671(+) A-I      intronic chr16:648231(+) A-I      intronic chr16:666600(+) A-I      intronic chr16:644949(+) A-I      intronic chr16:673705(+) A-I      intronic chr16:652616(+) A-I      intronic chr16:673425(+) A-I      intronic chr16:673560(+) A-I      intronic chr16:652753(+) A-I      intronic chr16:647548(+) A-I      intronic chr16:650575(+) A-I      intronic chr16:648239(+) A-I      intronic chr16:670338(+) A-I      intronic chr16:666560(+) A-I      intronic chr16:655075(+) A-I      intronic chr16:647724(+) A-I      intronic chr16:647660(+) A-I      intronic chr16:655110(+) A-I      intronic chr16:666105(+) A-I      intronic chr16:651873(+) A-I      intronic chr16:650586(+) A-I      intronic chr16:648662(+) A-I      intronic chr16:666537(+) A-I      intronic chr16:666599(+) A-I      intronic chr16:672641(+) A-I      intronic chr16:668490(+) A-I      intronic chr16:647846(+) A-I      intronic chr16:673581(+) A-I      intronic chr16:672532(+) A-I      intronic chr16:648257(+) A-I      intronic chr16:651979(+) A-I      intronic chr16:647587(+) A-I      intronic chr16:654912(+) A-I      intronic chr16:654904(+) A-I      intronic chr16:652832(+) A-I      intronic chr16:652494(+) A-I      intronic chr16:665771(+) A-I      intronic chr16:647564(+) A-I      intronic chr16:645720(+) A-I      intronic chr16:647545(+) A-I      intronic chr16:652456(+) A-I      intronic chr16:652568(+) A-I      intronic chr16:673507(+) A-I      intronic chr16:648221(+) A-I      intronic chr16:658994(+) A-I      intronic chr16:653050(+) A-I      intronic chr16:648434(+) A-I      intronic chr16:666103(+) A-I      intronic chr16:666104(+) A-I      intronic chr16:645041(+) A-I      intronic chr16:647488(+) A-I      intronic chr16:652513(+) A-I      intronic chr16:666612(+) A-I      intronic chr16:654123(+) A-I      intronic chr16:652750(+) A-I      intronic chr16:666100(+) A-I      intronic chr16:672787(+) A-I      intronic chr16:670286(+) A-I      intronic chr16:648216(+) A-I      intronic chr16:652574(+) A-I      intronic chr16:654899(+) A-I      intronic chr16:673386(+) A-I      intronic chr16:647495(+) A-I      intronic chr16:645039(+) A-I      intronic chr16:654835(+) A-I      intronic chr16:645000(+) A-I      intronic chr16:648652(+) A-I      intronic chr16:648657(+) A-I      intronic chr16:652388(+) A-I      intronic chr16:645878(+) A-I      intronic chr16:666432(+) A-I      intronic chr16:647632(+) A-I      intronic chr16:648359(+) A-I      intronic chr16:654128(+) A-I      intronic chr16:647750(+) A-I      intronic chr16:647628(+) A-I      intronic chr16:672637(+) A-I      intronic chr16:658669(+) A-I      intronic chr16:657415(+) A-I      intronic chr16:666561(+) A-I      intronic chr16:651939(+) A-I      intronic chr16:665700(+) A-I      intronic chr16:655013(+) A-I      intronic chr16:652694(+) A-I      intronic chr16:654907(+) A-I      intronic chr16:652618(+) A-I      intronic chr16:673574(+) A-I      intronic chr16:665842(+) A-I      intronic chr16:648085(+) A-I      intronic chr16:645786(+) A-I      intronic chr16:650601(+) A-I      intronic chr16:665707(+) A-I      intronic chr16:668421(+) A-I      intronic chr16:668413(+) A-I      intronic chr16:648218(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RAB40C	chr16:646421(+) A-I intron -    15342557 chr16:646571(+) A-I intron -    15342557 chr16:647750(+) A-I intron -    15342557   //15258596 chr16:647751(+) A-I intron -    15342557   //15258596 chr16:647764(+) A-I intron -    15342557   //15258596 chr16:647770(+) A-I intron -    15342557   //15258596 chr16:647839(+) A-I intron -    15342557 chr16:647846(+) A-I intron -    15342557 chr16:653051(+) A-I intron -    15342557 chr16:654804(+) A-I intron -    15342557 chr16:654835(+) A-I intron -    15342557 chr16:654850(+) A-I intron -    15342557 chr16:654874(+) A-I intron -    15342557 chr16:654898(+) A-I intron -    15342557 chr16:654902(+) A-I intron -    15342557 chr16:654904(+) A-I intron -    15342557 chr16:655013(+) A-I intron -    15342557 chr16:656302(+) A-I intron -    15342557 chr16:671682(+) A-I intron -    15342557 chr16:672532(+) A-I intron -    15342557 chr16:672641(+) A-I intron -    15342557   //15258596 chr16:672647(+) A-I intron -    15342557   //15258596 chr16:672667(+) A-I intron -    15342557   //15258596 chr16:672703(+) A-I intron -    15342557   //15258596 chr16:672706(+) A-I intron -    15342557   //15258596 chr16:673425(+) A-I intron -    15342557 chr16:648657(+) A-I intron -    22327324 chr16:648218(+) A-G intron -    22484847 chr16:648450(+) A-G intron -    22484847 chr16:648657(+) A-G intron -    22484847 chr16:670314(+) A-G intron -    22484847 chr16:673547(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RAB40C	chr16:639437-639438(+) m6A 5'UTR       25456834 chr16:639511-639512(+) m6A 5'UTR       25456834//24981863 chr16:639520-639521(+) m6A 5'UTR       25456834//24981863 chr16:639714-639715(+) m6A 5'UTR//intron       25456834//24981863 chr16:639726-639727(+) m6A 5'UTR//intron       - chr16:667221-667222(+) m6A 3'UTR//5'UTR//CDS       - chr16:668201-668202(+) m6A 3'UTR//CDS//intron       - chr16:675700-675701(+) m6A exon//intron       24284625 chr16:675932-675933(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625 chr16:675998-675999(+) m6A 3'UTR//5'UTR//CDS//exon       24284625 chr16:677356-677357(+) m6A CDS//exon       24284625 chr16:677590-677591(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:677671-677672(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:677713-677714(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:677788-677789(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:677857-677858(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:677931-677932(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:678043-678044(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:678058-678059(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:678137-678138(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:678313-678314(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:678344-678345(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:678360-678361(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:678406-678407(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:678437-678438(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22608085 chr16:678539-678540(+) m6A 3'UTR//exon       24284625 chr16:678571-678572(+) m6A 3'UTR//exon       24284625 chr16:678863-678864(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:678870-678871(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:678884-678885(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:678943-678944(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:678992-678993(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:679012-679013(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:679047-679048(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:679129-679130(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:679142-679143(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:679151-679152(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:679202-679203(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:679230-679231(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7f-2-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	RAB40C	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7f-2-3p
Interactor2: RAB40C

Evidence Support:

Strong-Evidence	Luciferase reporter assay//RT-PCR
Support Database	VIRmiRNA

References:

PMID	21565290	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	B-lymphocyte cells	Interactor2 expression	None
Description	We listed the cellular functions of these relevant miRNAs in liver disease and their biological properties associated with HBV or HBV-related HCC in Table 1. We also summarized the known changes of miRNAs involved in multiple steps of chronic hepatitis B, from hepatitis to cirrhosis and finally to HCC (Fig. 3).