Basic Information:

  VIRBase ID:  

HHID00026680

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7a-3p:  MIMAT0004481          HMGA2:  NM_003483     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7a-3p	HMGA2
miRBase Accession/Entrez ID	MIMAT0004481	8091
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BABL//HMGI-C//HMGIC//LIPO//SRS5//STQTL9

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7a-3p	rs1219969167 chr9:94176028    T/G rs1399588338 chr9:94176027    G/A rs1453867589 chr9:94176023    T/A rs770208205 chr9:94176022    C/T rs1265084977 chr22:46112817    T/C rs372596018 chr22:46112808    T/C rs1198423693 chr9:94176020    A/G rs748585376 chr9:94176015    A/G rs781681931 chr9:94176014    T/G rs972845958 chr9:94176013    CTA/C rs779353569 chr22:46112805    C/T rs970921980 chr22:46112807    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HMGA2	chr12:66237735(+) A-I      intronic chr12:66237595(+) A-I      intronic chr12:66281188(+) A-I      intronic chr12:66281189(+) A-I      intronic chr12:66281336(+) A-I      intronic chr12:66257017(+) A-I      intronic chr12:66257022(+) A-I      intronic chr12:66257636(+) A-I      intronic chr12:66280336(+) A-I      intronic chr12:66257011(+) A-I      intronic chr12:66256993(+) A-I      intronic chr12:66257662(+) A-I      intronic chr12:66257674(+) A-I      intronic chr12:66257676(+) A-I      intronic chr12:66281964(+) A-I      intronic chr12:66281994(+) A-I      intronic chr12:66292413(+) A-I      intronic chr12:66282076(+) A-I      intronic chr12:66255808(+) A-I      intronic chr12:66253750(+) A-I      intronic chr12:66282603(+) A-I      intronic chr12:66282604(+) A-I      intronic chr12:66239323(+) A-I      intronic chr12:66239301(+) A-I      intronic chr12:66239271(+) A-I      intronic chr12:66239166(+) A-I      intronic chr12:66239161(+) A-I      intronic chr12:66239149(+) A-I      intronic chr12:66239296(+) A-I      intronic chr12:66280313(+) A-I      intronic chr12:66280269(+) A-I      intronic chr12:66280257(+) A-I      intronic chr12:66280240(+) A-I      intronic chr12:66280339(+) A-I      intronic chr12:66237741(+) A-I      intronic chr12:66280341(+) A-I      intronic chr12:66280239(+) A-I      intronic chr12:66280322(+) A-I      intronic chr12:66257665(+) A-I      intronic chr12:66237670(+) A-I      intronic chr12:66237708(+) A-I      intronic chr12:66282113(+) A-I      intronic chr12:66280307(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HMGA2	chr12:66218258-66218259(+) m6A 5'UTR       24209618//25456834//24981863 chr12:66218267-66218268(+) m6A 5'UTR       24209618//25456834//24981863 chr12:66218301-66218302(+) m6A 5'UTR       24209618//25456834//24981863 chr12:66218603-66218604(+) m6A 5'UTR//exon       24209618//25456834//24981863 chr12:66219100-66219101(+) m6A CDS//exon       24209618//24981863 chr12:66221782-66221783(+) m6A CDS//exon       24209618//24981863 chr12:66221809-66221810(+) m6A CDS//exon       24209618//24981863//27773535 chr12:66221821-66221822(+) m6A CDS//exon       24209618//24981863//27773535 chr12:66221838-66221839(+) m6A CDS//exon       24209618//24981863//27773535 chr12:66221985-66221986(+) m6A exon//intron       24981863 chr12:66232336-66232337(+) m6A CDS       24209618//25456834//24981863 chr12:66275573-66275574(+) m6A 3'UTR//intron       24981863 chr12:66275605-66275606(+) m6A 3'UTR//intron       24981863 chr12:66275623-66275624(+) m6A 3'UTR//intron       24981863 chr12:66275871-66275872(+) m6A 3'UTR//intron       24981863 chr12:66357249-66357250(+) m6A 3'UTR       26404942 chr12:66357303-66357304(+) m6A 3'UTR       24981863//26404942 chr12:66357313-66357314(+) m6A 3'UTR       24981863//26404942 chr12:66357322-66357323(+) m6A 3'UTR       26404942 chr12:66357708-66357709(+) m6A 3'UTR       27773535 chr12:66357752-66357753(+) m6A 3'UTR       27773535 chr12:66358247-66358248(+) Y 3'UTR       26075521 chr12:66358282-66358283(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular vesicle Colon cancer cell line (LIM1863)     25330373 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	HMGA2	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7a-3p
Interactor2: HMGA2

Evidence Support:

Strong-Evidence	Luciferase reporter assay//RT-PCR
Support Database	VIRmiRNA

References:

PMID	21565290	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	B-lymphocyte cells	Interactor2 expression	None
Description	We listed the cellular functions of these relevant miRNAs in liver disease and their biological properties associated with HBV or HBV-related HCC in Table 1. We also summarized the known changes of miRNAs involved in multiple steps of chronic hepatitis B, from hepatitis to cirrhosis and finally to HCC (Fig. 3).