Basic Information:

  VIRBase ID:  

HHID00026632

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7i-5p:  MIMAT0000415          HMGA2:  NM_003483     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7i-5p	HMGA2
miRBase Accession/Entrez ID	MIMAT0000415	8091
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BABL//HMGI-C//HMGIC//LIPO//SRS5//STQTL9

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7i-5p	rs1207803327 chr12:62603708    C/T rs1265187764 chr12:62603700    A/G rs1273095827 chr12:62603710    G/C rs1343283980 chr12:62603701    GT/G rs750854486 chr12:62603712    TG/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HMGA2	chr12:66237735(+) A-I      intronic chr12:66237595(+) A-I      intronic chr12:66281188(+) A-I      intronic chr12:66281189(+) A-I      intronic chr12:66281336(+) A-I      intronic chr12:66257017(+) A-I      intronic chr12:66257022(+) A-I      intronic chr12:66257636(+) A-I      intronic chr12:66280336(+) A-I      intronic chr12:66257011(+) A-I      intronic chr12:66256993(+) A-I      intronic chr12:66257662(+) A-I      intronic chr12:66257674(+) A-I      intronic chr12:66257676(+) A-I      intronic chr12:66281964(+) A-I      intronic chr12:66281994(+) A-I      intronic chr12:66292413(+) A-I      intronic chr12:66282076(+) A-I      intronic chr12:66255808(+) A-I      intronic chr12:66253750(+) A-I      intronic chr12:66282603(+) A-I      intronic chr12:66282604(+) A-I      intronic chr12:66239323(+) A-I      intronic chr12:66239301(+) A-I      intronic chr12:66239271(+) A-I      intronic chr12:66239166(+) A-I      intronic chr12:66239161(+) A-I      intronic chr12:66239149(+) A-I      intronic chr12:66239296(+) A-I      intronic chr12:66280313(+) A-I      intronic chr12:66280269(+) A-I      intronic chr12:66280257(+) A-I      intronic chr12:66280240(+) A-I      intronic chr12:66280339(+) A-I      intronic chr12:66237741(+) A-I      intronic chr12:66280341(+) A-I      intronic chr12:66280239(+) A-I      intronic chr12:66280322(+) A-I      intronic chr12:66257665(+) A-I      intronic chr12:66237670(+) A-I      intronic chr12:66237708(+) A-I      intronic chr12:66282113(+) A-I      intronic chr12:66280307(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HMGA2	chr12:66218258-66218259(+) m6A 5'UTR       24209618//25456834//24981863 chr12:66218267-66218268(+) m6A 5'UTR       24209618//25456834//24981863 chr12:66218301-66218302(+) m6A 5'UTR       24209618//25456834//24981863 chr12:66218603-66218604(+) m6A 5'UTR//exon       24209618//25456834//24981863 chr12:66219100-66219101(+) m6A CDS//exon       24209618//24981863 chr12:66221782-66221783(+) m6A CDS//exon       24209618//24981863 chr12:66221809-66221810(+) m6A CDS//exon       24209618//24981863//27773535 chr12:66221821-66221822(+) m6A CDS//exon       24209618//24981863//27773535 chr12:66221838-66221839(+) m6A CDS//exon       24209618//24981863//27773535 chr12:66221985-66221986(+) m6A exon//intron       24981863 chr12:66232336-66232337(+) m6A CDS       24209618//25456834//24981863 chr12:66275573-66275574(+) m6A 3'UTR//intron       24981863 chr12:66275605-66275606(+) m6A 3'UTR//intron       24981863 chr12:66275623-66275624(+) m6A 3'UTR//intron       24981863 chr12:66275871-66275872(+) m6A 3'UTR//intron       24981863 chr12:66357249-66357250(+) m6A 3'UTR       26404942 chr12:66357303-66357304(+) m6A 3'UTR       24981863//26404942 chr12:66357313-66357314(+) m6A 3'UTR       24981863//26404942 chr12:66357322-66357323(+) m6A 3'UTR       26404942 chr12:66357708-66357709(+) m6A 3'UTR       27773535 chr12:66357752-66357753(+) m6A 3'UTR       27773535 chr12:66358247-66358248(+) Y 3'UTR       26075521 chr12:66358282-66358283(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7i-5p	Apoptotic body Human umbilical vein endothelial cells     19996457 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm HeLa cells     22058130 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Hetastatic gastric cancer cell line (AZ-P7a)     20949044 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Human esophageal cancer cell line (EC9706)     25184951 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Hepatoma cells     23771658 Microvesicle Blood|Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HeLa cells     22058130
	HMGA2	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-let-7i-5p	Formaldehyde 712 Drug interaction    RC00002392 Oxaliplatine 6857599 Drug interaction    RC00002408 Bisphenol A 6623 Drug interaction    RC00002399 Gemcitabine 60750 Drug interaction    RC00002403 Estradiol 5757 Drug interaction    RC00002398 Eloxatine 5310940 Drug interaction    RC00002407 Imatinib 5291 Drug interaction    RC00002397 Decitabine 451668 Drug interaction    RC00002405 Etoposide 36462 Drug interaction    RC00002402 Paclitaxel 36314 Drug interaction    RC00002401 5-Fluorouracil 3385 Drug interaction    RC00002396 Enoxacin 3229 Drug interaction    RC00002395 Doxorubicin 31703 Drug interaction    RC00002400 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002394 Tamoxifen 2733526 Drug interaction    RC00002406 Verapamil 2520 Drug interaction    RC00002393 Leucovorin 135403648 Drug interaction    RC00002409 Ginsenoside Rh2 119307 Drug interaction    RC00002404 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00002410 Marine fungal metabolite 1386A - Drug interaction    RC00002411 Mistletoe lectin-I - Drug interaction    RC00002412 Chemotherapy - Drug interaction    RC00008840

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-let-7i-5p	Platinum 23939       25872328

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7i-5p
Interactor2: HMGA2

Evidence Support:

Strong-Evidence	Luciferase reporter assay//RT-PCR
Support Database	VIRmiRNA

References:

PMID	21565290	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	B-lymphocyte cells	Interactor2 expression	None
Description	We listed the cellular functions of these relevant miRNAs in liver disease and their biological properties associated with HBV or HBV-related HCC in Table 1. We also summarized the known changes of miRNAs involved in multiple steps of chronic hepatitis B, from hepatitis to cirrhosis and finally to HCC (Fig. 3).