Detail Information

Basic Information:


  VIRBase ID:  

HHID00026629

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9853

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7i-5p:           CD59:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-let-7i-5p CD59
miRBase
Accession/Entrez ID		 MIMAT0000415 966
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - 16.3A5//1F5//EJ16//EJ30//EL32//G344//HRF-20//HRF20//MAC-IP//MACIF//MEM43//MIC11//MIN1//MIN2//MIN3//MIRL//MSK21//p18-20

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-let-7i-5p
rs1207803327 chr12:62603708    C/T
rs1265187764 chr12:62603700    A/G
rs1273095827 chr12:62603710    G/C
rs1343283980 chr12:62603701    GT/G
rs750854486 chr12:62603712    TG/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CD59
chr11:33723662(-) A-I      intronic
chr11:33723193(-) A-I      intronic
chr11:33723189(-) A-I      intronic
chr11:33733146(-) A-I      intronic
chr11:33733224(-) A-I      intronic
chr11:33732821(-) A-I      intronic
chr11:33736601(-) A-I      intronic
chr11:33732754(-) A-I      intronic
chr11:33732353(-) A-I      intronic
chr11:33737139(-) A-I      intronic
chr11:33732756(-) A-I      intronic
chr11:33736599(-) A-I      intronic
chr11:33736587(-) A-I      intronic
chr11:33732289(-) A-I      intronic
chr11:33733140(-) A-I      intronic
chr11:33733225(-) A-I      intronic
chr11:33737071(-) A-I      intronic
chr11:33732379(-) A-I      intronic
chr11:33736537(-) A-I      intronic
chr11:33733136(-) A-I      intronic
chr11:33723206(-) A-I      intronic
chr11:33733223(-) A-I      intronic
chr11:33733155(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CD59
chr11:33720019-33720020(-) m6A 3'UTR//CDS       -
chr11:33730256-33730257(-) m6A 3'UTR//intron       24284625
chr11:33730474-33730475(-) Cm 3'UTR//exon//intron       -
chr11:33731099-33731100(-) m6A 3'UTR//exon//intron       24284625//25456834//24981863//26404942//27773535//22575960//22608085
chr11:33731147-33731148(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr11:33731177-33731178(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr11:33731242-33731243(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr11:33731399-33731400(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr11:33731435-33731436(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr11:33731503-33731504(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr11:33731512-33731513(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr11:33731644-33731645(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr11:33731727-33731728(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:33731745-33731746(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:33731764-33731765(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:33731783-33731784(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:33738966-33738967(-) m6A CDS//exon       24284625//27371828//27773536//22575960
chr11:33739064-33739065(-) m6A exon//intron       24284625//27371828//27773536//22575960
chr11:33743999-33744000(-) m6A 5'UTR       24284625//25456834//24981863//22608085
chr11:33744063-33744064(-) m6A 5'UTR//intron       24284625//25456834//24981863
chr11:33752983-33752984(-) m6A 5'UTR//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-let-7i-5p
Apoptotic body Human umbilical vein endothelial cells     19996457
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm HeLa cells     22058130
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Hetastatic gastric cancer cell line (AZ-P7a)     20949044
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Human esophageal cancer cell line (EC9706)     25184951
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Hepatoma cells     23771658
Microvesicle Blood|Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa cells     22058130
CD59
Chromatin K562 cells     -
Cytosol HeLa-S3 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-let-7i-5p
Formaldehyde 712 Drug interaction    RC00002392
Oxaliplatine 6857599 Drug interaction    RC00002408
Bisphenol A 6623 Drug interaction    RC00002399
Gemcitabine 60750 Drug interaction    RC00002403
Estradiol 5757 Drug interaction    RC00002398
Eloxatine 5310940 Drug interaction    RC00002407
Imatinib 5291 Drug interaction    RC00002397
Decitabine 451668 Drug interaction    RC00002405
Etoposide 36462 Drug interaction    RC00002402
Paclitaxel 36314 Drug interaction    RC00002401
5-Fluorouracil 3385 Drug interaction    RC00002396
Enoxacin 3229 Drug interaction    RC00002395
Doxorubicin 31703 Drug interaction    RC00002400
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002394
Tamoxifen 2733526 Drug interaction    RC00002406
Verapamil 2520 Drug interaction    RC00002393
Leucovorin 135403648 Drug interaction    RC00002409
Ginsenoside Rh2 119307 Drug interaction    RC00002404
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00002410
Marine fungal metabolite 1386A - Drug interaction    RC00002411
Mistletoe lectin-I - Drug interaction    RC00002412
Chemotherapy - Drug interaction    RC00008840
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-let-7i-5p
Platinum 23939       25872328

Interaction Network (The top 100 interactions):


Interactor1: hsa-let-7i-5p
Interactor2: CD59

Evidence Support:


Strong-Evidence ELISA//Luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence Targetscan
Support Database ViRBase

References:


[1]PMID 21665888 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HepG2 cells//HepG2.2.15 cells//HepG2-P cells//HepG2-X cells Interactor2 expression Upregulation
Description However, western blot analysis revealed that the protein level of CD59 was markedly reduced by 100 nM let-7i treatment relative to let-7i Ctrl ( Figure 4C ), whereas transient transfection with 100 nM anti-let-7i was sufficient to increase the protein expression of CD59 relative to anti-let-7i Ctrl in HBx-negative cells ( Figure 4C ). Thus, we conclude that let-7i is able to down-regulate the expression of CD59 at the post-transcriptional level.
[2]PMID 22425745 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HepG2 cells//HepG2.2.15 cells//HepG2-P cells//HepG2-X cells Interactor2 expression Upregulation
Description HBx up-regulates CD59 by let-7i at the post-transcriptional level, contributing to escape of HCC cells from complement-dependent cytotoxicity.

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