Detail Information

Basic Information:


  VIRBase ID:  

HHID00026623

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7g-5p:           CASP3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-let-7g-5p CASP3
miRBase
Accession/Entrez ID		 MIMAT0000414 836
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CPP32//CPP32B//SCA-1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CASP3
chr4:185563395(-) A-I      intronic
chr4:185563394(-) A-I      intronic
chr4:185563384(-) A-I      intronic
chr4:185563373(-) A-I      intronic
chr4:185563404(-) A-I      intronic
chr4:185563238(-) A-I      intronic
chr4:185563248(-) A-I      intronic
chr4:185563256(-) A-I      intronic
chr4:185563258(-) A-I      intronic
chr4:185563263(-) A-I      intronic
chr4:185563366(-) A-I      intronic
chr4:185563267(-) A-I      intronic
chr4:185563281(-) A-I      intronic
chr4:185563282(-) A-I      intronic
chr4:185563287(-) A-I      intronic
chr4:185558634(-) A-I      intronic
chr4:185558588(-) A-I      intronic
chr4:185558356(-) A-I      intronic
chr4:185564752(-) A-I      intronic
chr4:185564777(-) A-I      intronic
chr4:185564768(-) A-I      intronic
chr4:185564626(-) A-I      intronic
chr4:185563358(-) A-I      intronic
chr4:185557396(-) A-I      intronic
chr4:185563253(-) A-I      intronic
chr4:185557349(-) A-I      intronic
chr4:185558689(-) A-I      intronic
chr4:185558232(-) A-I      intronic
chr4:185558615(-) A-I      intronic
chr4:185551739(-) A-I      intronic
chr4:185558568(-) A-I      intronic
chr4:185563319(-) A-I      intronic
chr4:185566909(-) A-I      intronic
chr4:185566948(-) A-I      intronic
chr4:185558311(-) A-I      intronic
chr4:185558258(-) A-I      intronic
chr4:185558672(-) A-I      intronic
chr4:185560238(-) A-I      intronic
chr4:185560360(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CASP3
chr4:185570553(-) A-I exon 5'UTR    19478186
chr4:185558311(-) A-G intron -    22484847
chr4:185558672(-) A-G intron -    22484847
chr4:185563358(-) A-G intron -    22484847
chr4:185566794(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CASP3
chr4:185549472-185549473(-) m6A 3'UTR       24981863
chr4:185556524-185556525(-) m6A CDS       -
chr4:185556542-185556543(-) m6A CDS       -
chr4:185559556-185559557(-) m6A CDS       24981863
chr4:185559590-185559591(-) m6A CDS       24981863//27773535
chr4:185559599-185559600(-) m6A CDS       24981863//27773535
chr4:185565779-185565780(-) m6A 5'UTR//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-let-7g-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm HeLa cells     22058130
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Human cervical cancer cell line (HeLa)     25760330
Exosome Hetastatic gastric cancer cell line (AZ-P7a)     20949044
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Renal cancer cells     21670082
Exosome Breast milk     22211110
Exosome Epidermal melanocytes (HEMa-LP)|Malignant melanoma cell line (A375)     23056502
Exosome Saliva     23302638
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human esophageal cancer cell line (EC9706)     25184951
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Plasma     19002258
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Hepatoma cells     23771658
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion HEK-293 cells|HeLa cells|Myotube     27396686
Mitochondrion HEK-293 cells|HeLa cells|Skeletal muscle cells     27563705
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa cells     22058130
CASP3
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-let-7g-5p
1H-Indole-3-methanol, 1-[(4-chlorophenyl)methyl]- 11821732 Drug resistant
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-let-7g-5p
10-Hydroxycamptothecin 97226 Drug interaction    RC00002386
Formaldehyde 712 Drug interaction    RC00002374
Oxaliplatine 6857599 Drug interaction    RC00002388
Bisphenol A 6623 Drug interaction    RC00002379
Estradiol 5757 Drug interaction    RC00002378
Decitabine 451668 Drug interaction    RC00002387
Carboplatinum 38904 Drug interaction    RC00002385
Etoposide 36462 Drug interaction    RC00002384
Paclitaxel 36314 Drug interaction    RC00002383
5-Fluorouracil 3385 Drug interaction    RC00002377
Doxorubicin 31703 Drug interaction    RC00002382
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002376
Verapamil 2520 Drug interaction    RC00002375
Arsenic trioxide 14888 Drug interaction    RC00002381
Leucovorin 135403648 Drug interaction    RC00002389
Vinblastine 13342 Drug interaction    RC00002380
modified ALLIC BFM 2002 protocol - Drug interaction    RC00002390
Marine fungal metabolite 1386A - Drug interaction    RC00002391
Chemotherapy - Drug interaction    RC00008839
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-let-7g-5p
Paclitaxel 36314       26323677
Platinum 23939       25872328

Interaction Network (The top 100 interactions):


Interactor1: hsa-let-7g-5p
Interactor2: CASP3

Evidence Support:


Strong-Evidence Luciferase reporter assay//RT-PCR
Support Database VIRmiRNA

References:


PMID 21565290 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line B-lymphocyte cells Interactor2 expression None
Description We listed the cellular functions of these relevant miRNAs in liver disease and their biological properties associated with HBV or HBV-related HCC in Table 1. We also summarized the known changes of miRNAs involved in multiple steps of chronic hepatitis B, from hepatitis to cirrhosis and finally to HCC (Fig. 3).

Starting a new search, please wait ...