Basic Information:

  VIRBase ID:  

HHID00026554

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1304-3p:  MIMAT0022720          MLKL:  NM_152649     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1304-3p	MLKL
miRBase Accession/Entrez ID	MIMAT0022720	197259
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	hMLKL

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1304-3p	rs1442154681 chr11:93733696    T/G rs201086870 chr11:93733694    G/T rs2155248 chr11:93733700    G/C rs2155248 chr11:93733700    G/T rs751129343 chr11:93733701    G/A rs752455867 chr11:93733697    C/T rs753786516 chr11:93733693    G/A rs753786516 chr11:93733693    G/T rs758093324 chr11:93733698    G/A rs760841322 chr11:93733691    G/C rs766304845 chr11:93733692    G/A rs766304845 chr11:93733692    G/C rs1249769237 chr11:93733705    C/T rs756791611 chr11:93733709    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MLKL	chr16:74715083(-) A-I      intronic chr16:74715072(-) A-I      intronic chr16:74713613(-) A-I      intronic chr16:74713540(-) A-I      intronic chr16:74713513(-) A-I      intronic chr16:74713488(-) A-I      intronic chr16:74713476(-) A-I      intronic chr16:74713589(-) A-I      intronic chr16:74712572(-) A-I      intronic chr16:74712477(-) A-I      intronic chr16:74717407(-) A-I      intronic chr16:74708147(-) A-I      intronic chr16:74711756(-) A-I      intronic chr16:74720006(-) A-I      intronic chr16:74719996(-) A-I      intronic chr16:74717418(-) A-I      intronic chr16:74717411(-) A-I      intronic chr16:74717408(-) A-I      intronic chr16:74717370(-) A-I      intronic chr16:74717124(-) A-I      intronic chr16:74717095(-) A-I      intronic chr16:74717067(-) A-I      intronic chr16:74715088(-) A-I      intronic chr16:74717974(-) A-I      intronic chr16:74717984(-) A-I      intronic chr16:74718010(-) A-I      intronic chr16:74718013(-) A-I      intronic chr16:74718022(-) A-I      intronic chr16:74718039(-) A-I      intronic chr16:74718042(-) A-I      intronic chr16:74718078(-) A-I      intronic chr16:74718092(-) A-I      intronic chr16:74718561(-) A-I      intronic chr16:74718860(-) A-I      intronic chr16:74718927(-) A-I      intronic chr16:74718932(-) A-I      intronic chr16:74718944(-) A-I      intronic chr16:74718980(-) A-I      intronic chr16:74715128(-) A-I      intronic chr16:74715048(-) A-I      intronic chr16:74715015(-) A-I      intronic chr16:74714999(-) A-I      intronic chr16:74714670(-) A-I      intronic chr16:74714569(-) A-I      intronic chr16:74714558(-) A-I      intronic chr16:74714549(-) A-I      intronic chr16:74714490(-) A-I      intronic chr16:74714477(-) A-I      intronic chr16:74713591(-) A-I      intronic chr16:74712658(-) A-I      intronic chr16:74712599(-) A-I      intronic chr16:74712594(-) A-I      intronic chr16:74712573(-) A-I      intronic chr16:74712553(-) A-I      intronic chr16:74712425(-) A-I      intronic chr16:74712419(-) A-I      intronic chr16:74711614(-) A-I      intronic chr16:74711597(-) A-I      intronic chr16:74711549(-) A-I      intronic chr16:74711472(-) A-I      intronic chr16:74711364(-) A-I      intronic chr16:74711333(-) A-I      intronic chr16:74713630(-) A-I      intronic chr16:74711099(-) A-I      intronic chr16:74711048(-) A-I      intronic chr16:74708378(-) A-I      intronic chr16:74711583(-) A-I      intronic chr16:74717276(-) A-I      intronic chr16:74717259(-) A-I      intronic chr16:74717249(-) A-I      intronic chr16:74717085(-) A-I      intronic chr16:74717069(-) A-I      intronic chr16:74717058(-) A-I      intronic chr16:74717044(-) A-I      intronic chr16:74717041(-) A-I      intronic chr16:74717027(-) A-I      intronic chr16:74717004(-) A-I      intronic chr16:74716142(-) A-I      intronic chr16:74711118(-) A-I      intronic chr16:74718014(-) A-I      intronic chr16:74716132(-) A-I      intronic chr16:74716042(-) A-I      intronic chr16:74716041(-) A-I      intronic chr16:74715909(-) A-I      intronic chr16:74715885(-) A-I      intronic chr16:74715543(-) A-I      intronic chr16:74719035(-) A-I      intronic chr16:74719041(-) A-I      intronic chr16:74720299(-) A-I      intronic chr16:74720322(-) A-I      intronic chr16:74720369(-) A-I      intronic chr16:74727217(-) A-I      intronic chr16:74720373(-) A-I      intronic chr16:74715473(-) A-I      intronic chr16:74715191(-) A-I      intronic chr16:74721951(-) A-I      intronic chr16:74728613(-) A-I      intronic chr16:74728608(-) A-I      intronic chr16:74728592(-) A-I      intronic chr16:74728491(-) A-I      intronic chr16:74728428(-) A-I      intronic chr16:74727773(-) A-I      intronic chr16:74727676(-) A-I      intronic chr16:74727666(-) A-I      intronic chr16:74727231(-) A-I      intronic chr16:74727218(-) A-I      intronic chr16:74721101(-) A-I      intronic chr16:74721130(-) A-I      intronic chr16:74721862(-) A-I      intronic chr16:74721903(-) A-I      intronic chr16:74721904(-) A-I      intronic chr16:74717289(-) A-I      intronic chr16:74722076(-) A-I      intronic chr16:74722114(-) A-I      intronic chr16:74722154(-) A-I      intronic chr16:74722432(-) A-I      intronic chr16:74722500(-) A-I      intronic chr16:74722525(-) A-I      intronic chr16:74723019(-) A-I      intronic chr16:74723193(-) A-I      intronic chr16:74717957(-) A-I      intronic chr16:74717954(-) A-I      intronic chr16:74717914(-) A-I      intronic chr16:74717372(-) A-I      intronic chr16:74717354(-) A-I      intronic chr16:74717346(-) A-I      intronic chr16:74717290(-) A-I      intronic chr16:74720018(-) A-I      intronic chr16:74728624(-) A-I      intronic chr16:74712437(-) A-I      intronic chr16:74727266(-) A-I      intronic chr16:74714684(-) A-I      intronic chr16:74720054(-) A-I      intronic chr16:74712464(-) A-I      intronic chr16:74712498(-) A-I      intronic chr16:74711741(-) A-I      intronic chr16:74714692(-) A-I      intronic chr16:74711535(-) A-I      intronic chr16:74711349(-) A-I      intronic chr16:74718621(-) A-I      intronic chr16:74722382(-) A-I      intronic chr16:74718970(-) A-I      intronic chr16:74713480(-) A-I      intronic chr16:74714983(-) A-I      intronic chr16:74716140(-) A-I      intronic chr16:74713644(-) A-I      intronic chr16:74714637(-) A-I      intronic chr16:74717250(-) A-I      intronic chr16:74713446(-) A-I      intronic chr16:74711089(-) A-I      intronic chr16:74715182(-) A-I      intronic chr16:74715432(-) A-I      intronic chr16:74723051(-) A-I      intronic chr16:74714608(-) A-I      intronic chr16:74712533(-) A-I      intronic chr16:74715524(-) A-I      intronic chr16:74714994(-) A-I      intronic chr16:74718652(-) A-I      intronic chr16:74711715(-) A-I      intronic chr16:74714526(-) A-I      intronic chr16:74712581(-) A-I      intronic chr16:74727102(-) A-I      intronic chr16:74715061(-) A-I      intronic chr16:74714678(-) A-I      intronic chr16:74715118(-) A-I      intronic chr16:74714689(-) A-I      intronic chr16:74708377(-) A-I      intronic chr16:74721820(-) A-I      intronic chr16:74711480(-) A-I      intronic chr16:74727209(-) A-I      intronic chr16:74711838(-) A-I      intronic chr16:74715101(-) A-I      intronic chr16:74722440(-) A-I      intronic chr16:74715196(-) A-I      intronic chr16:74715080(-) A-I      intronic chr16:74727096(-) A-I      intronic chr16:74711223(-) A-I      intronic chr16:74713650(-) A-I      intronic chr16:74711869(-) A-I      intronic chr16:74711751(-) A-I      intronic chr16:74714533(-) A-I      intronic chr16:74715038(-) A-I      intronic chr16:74713707(-) A-I      intronic chr16:74711361(-) A-I      intronic chr16:74716094(-) A-I      intronic chr16:74715435(-) A-I      intronic chr16:74712692(-) A-I      intronic chr16:74711079(-) A-I      intronic chr16:74711492(-) A-I      intronic chr16:74711377(-) A-I      intronic chr16:74719982(-) A-I      intronic chr16:74717020(-) A-I      intronic chr16:74718571(-) A-I      intronic chr16:74715062(-) A-I      intronic chr16:74717328(-) A-I      intronic chr16:74717337(-) A-I      intronic chr16:74715971(-) A-I      intronic chr16:74711381(-) A-I      intronic chr16:74717425(-) A-I      intronic chr16:74715097(-) A-I      intronic chr16:74712452(-) A-I      intronic chr16:74711453(-) A-I      intronic chr16:74716029(-) A-I      intronic chr16:74722536(-) A-I      intronic chr16:74714952(-) A-I      intronic chr16:74716053(-) A-I      intronic chr16:74716015(-) A-I      intronic chr16:74715961(-) A-I      intronic chr16:74717394(-) A-I      intronic chr16:74718981(-) A-I      intronic chr16:74717302(-) A-I      intronic chr16:74717015(-) A-I      intronic chr16:74717059(-) A-I      intronic chr16:74711781(-) A-I      intronic chr16:74728568(-) A-I      intronic chr16:74711828(-) A-I      intronic chr16:74714575(-) A-I      intronic chr16:74707756(-) A-I      intronic chr16:74711135(-) A-I      intronic chr16:74711701(-) A-I      intronic chr16:74711851(-) A-I      intronic chr16:74711121(-) A-I      intronic chr16:74714578(-) A-I      intronic chr16:74727283(-) A-I      intronic chr16:74727149(-) A-I      intronic chr16:74711673(-) A-I      intronic chr16:74715127(-) A-I      intronic chr16:74718490(-) A-I      intronic chr16:74715031(-) A-I      intronic chr16:74712515(-) A-I      intronic chr16:74728528(-) A-I      intronic chr16:74712518(-) A-I      intronic chr16:74711390(-) A-I      intronic chr16:74713585(-) A-I      intronic chr16:74716058(-) A-I      intronic chr16:74712559(-) A-I      intronic chr16:74711152(-) A-I      intronic chr16:74722455(-) A-I      intronic chr16:74718936(-) A-I      intronic chr16:74714545(-) A-I      intronic chr16:74720139(-) A-I      intronic chr16:74724548(-) A-I      intronic chr16:74722401(-) A-I      intronic chr16:74719017(-) A-I      intronic chr16:74711169(-) A-I      intronic chr16:74712680(-) A-I      intronic chr16:74715510(-) A-I      intronic chr16:74711779(-) A-I      intronic chr16:74714573(-) A-I      intronic chr16:74728585(-) A-I      intronic chr16:74717099(-) A-I      intronic chr16:74716031(-) A-I      intronic chr16:74716096(-) A-I      intronic chr16:74707777(-) A-I      intronic chr16:74719925(-) A-I      intronic chr16:74720224(-) A-I      intronic chr16:74711043(-) A-I      intronic chr16:74712598(-) A-I      intronic chr16:74711702(-) A-I      intronic chr16:74714645(-) A-I      intronic chr16:74718573(-) A-I      intronic chr16:74714624(-) A-I      intronic chr16:74716964(-) A-I      intronic chr16:74711584(-) A-I      intronic chr16:74711125(-) A-I      intronic chr16:74707723(-) A-I      intronic chr16:74717002(-) A-I      intronic chr16:74713523(-) A-I      intronic chr16:74711342(-) A-I      intronic chr16:74718572(-) A-I      intronic chr16:74727573(-) A-I      intronic chr16:74714583(-) A-I      intronic chr16:74718626(-) A-I      intronic chr16:74712674(-) A-I      intronic chr16:74722342(-) A-I      intronic chr16:74712618(-) A-I      intronic chr16:74711628(-) A-I      intronic chr16:74713583(-) A-I      intronic chr16:74713503(-) A-I      intronic chr16:74715117(-) A-I      intronic chr16:74712605(-) A-I      intronic chr16:74715103(-) A-I      intronic chr16:74712524(-) A-I      intronic chr16:74715170(-) A-I      intronic chr16:74719990(-) A-I      intronic chr16:74711709(-) A-I      intronic chr16:74716071(-) A-I      intronic chr16:74718940(-) A-I      intronic chr16:74715502(-) A-I      intronic chr16:74728629(-) A-I      intronic chr16:74711844(-) A-I      intronic chr16:74714581(-) A-I      intronic chr16:74711810(-) A-I      intronic chr16:74730992(-) A-I      intronic chr16:74711047(-) A-I      intronic chr16:74708148(-) A-I      intronic chr16:74708395(-) A-I      intronic chr16:74714998(-) A-I      intronic chr16:74712672(-) A-I      intronic chr16:74714516(-) A-I      intronic chr16:74711391(-) A-I      intronic chr16:74721994(-) A-I      intronic chr16:74707779(-) A-I      intronic chr16:74715175(-) A-I      intronic chr16:74716217(-) A-I      intronic chr16:74711777(-) A-I      intronic chr16:74715100(-) A-I      intronic chr16:74726968(-) A-I      intronic chr16:74711679(-) A-I      intronic chr16:74711501(-) A-I      intronic chr16:74718223(-) A-I      intronic chr16:74711132(-) A-I      intronic chr16:74714194(-) A-I      intronic chr16:74728935(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MLKL	chr16:74705961(-) A-I exon 3'UTR    15342557 chr16:74706349(-) A-I exon 3'UTR    15342557 chr16:74710254(-) A-I intron -    15342557 chr16:74710728(-) A-I intron -    15342557 chr16:74711043(-) A-I intron -    15342557 chr16:74711673(-) A-I intron -    15342557 chr16:74711701(-) A-I intron -    15342557 chr16:74711741(-) A-I intron -    15342557 chr16:74711751(-) A-I intron -    15342557 chr16:74711777(-) A-I intron -    15342557 chr16:74711779(-) A-I intron -    15342557 chr16:74711781(-) A-I intron -    15342557 chr16:74711810(-) A-I intron -    15342557 chr16:74711838(-) A-I intron -    15342557 chr16:74711964(-) A-I intron -    15342557 chr16:74715061(-) A-I intron -    22327324 chr16:74708148(-) A-G intron -    22484847 chr16:74712598(-) A-G intron -    22484847 chr16:74712674(-) A-G intron -    22484847 chr16:74714983(-) A-G intron -    22484847 chr16:74714994(-) A-G intron -    22484847 chr16:74714998(-) A-G intron -    22484847 chr16:74715061(-) A-G intron -    22484847 chr16:74715971(-) A-G intron -    22484847 chr16:74717015(-) A-G intron -    22484847 chr16:74720139(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MLKL	chr16:74705830-74705831(-) m6A 3'UTR//exon       24284625//24981863//27773535 chr16:74705839-74705840(-) m6A 3'UTR//exon       24284625//24981863//27773535 chr16:74705911-74705912(-) m6A 3'UTR//exon       24284625//24981863//27773535//27371828 chr16:74705927-74705928(-) m6A 3'UTR//exon       24284625//24981863//27773535//27371828 chr16:74705959-74705960(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//27371828 chr16:74705976-74705977(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535 chr16:74706209-74706210(-) m6A 3'UTR//exon       24284625//24981863//27773535 chr16:74706240-74706241(-) m6A 3'UTR//exon       24284625 chr16:74706341-74706342(-) m6A 3'UTR//exon       24981863 chr16:74706346-74706347(-) m6A 3'UTR//exon       24981863 chr16:74706364-74706365(-) Am 3'UTR//exon       - chr16:74726251-74726252(-) m6A CDS       24981863 chr16:74729224-74729225(-) m6A CDS       24981863//22575960 chr16:74729350-74729351(-) m6A CDS       24981863//22575960 chr16:74729374-74729375(-) m6A CDS       24981863 chr16:74729467-74729468(-) m6A CDS       24284625 chr16:74729515-74729516(-) m6A CDS       24284625 chr16:74729577-74729578(-) m6A CDS       24284625//27371828 chr16:74734383-74734384(-) Cm 5'UTR       - chr16:74734384-74734385(-) m6A 5'UTR       24284625//24981863//27371828 chr16:74734396-74734397(-) m6A 5'UTR       24284625//24981863//27371828 chr16:74734456-74734457(-) m6A 5'UTR//intron       24284625//24981863//27371828 chr16:74734481-74734482(-) m6A 5'UTR//intron       24284625//24981863//27371828 chr16:74734621-74734622(-) m6A 5'UTR       24284625//24981863//27371828//22575960 chr16:74734649-74734650(-) m6A 5'UTR       24284625//24981863//27371828 chr16:74734655-74734656(-) m6A 5'UTR       24284625//24981863//27371828 chr16:74734686-74734687(-) m6A 5'UTR       24284625//24981863//27371828 chr16:74734829-74734830(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1304-3p	Exosome Plasma     23663360 Exosome Kidney tissue     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	MLKL	Cytosol HCC cell line (HepG2)     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1304-3p
Interactor2: MLKL

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//miRTarBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32232013	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HUVEC cells	Interactor2 expression	Upregulation
Description	Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).