Detail Information

Basic Information:


  VIRBase ID:  

HHID00026480

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1304-3p:           KLF4:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1304-3p KLF4
miRBase
Accession/Entrez ID		 MIMAT0022720 9314
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - EZF//GKLF

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1304-3p
rs1442154681 chr11:93733696    T/G
rs201086870 chr11:93733694    G/T
rs2155248 chr11:93733700    G/C
rs2155248 chr11:93733700    G/T
rs751129343 chr11:93733701    G/A
rs752455867 chr11:93733697    C/T
rs753786516 chr11:93733693    G/A
rs753786516 chr11:93733693    G/T
rs758093324 chr11:93733698    G/A
rs760841322 chr11:93733691    G/C
rs766304845 chr11:93733692    G/A
rs766304845 chr11:93733692    G/C
rs1249769237 chr11:93733705    C/T
rs756791611 chr11:93733709    G/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase KLF4
chr9:110247697-110247698(-) m6A 3'UTR//exon       24284625//24981863//27773535//22575960//22608085
chr9:110247776-110247777(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//22575960//22608085
chr9:110247841-110247842(-) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr9:110247855-110247856(-) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr9:110248023-110248024(-) m6A 3'UTR//exon       24284625//24981863//27773535//22575960//22608085
chr9:110248065-110248066(-) m6A CDS//exon       24284625//24981863//27773535//22575960//22608085
chr9:110248124-110248125(-) m6A CDS//exon       24284625//24981863//27773535//27371828//22575960//22608085
chr9:110248145-110248146(-) m6A CDS//exon       24284625//24981863//27773535//27371828//22575960//22608085
chr9:110248199-110248200(-) m6A CDS//exon       24284625//24981863//27773535//22575960//22608085
chr9:110249317-110249318(-) m6A CDS//exon       24284625//24981863//27773535//22575960//22608085
chr9:110249356-110249357(-) m6A CDS//exon       24284625//24981863//27773535//22575960
chr9:110249395-110249396(-) m6A CDS//exon       24284625//24981863//27773535
chr9:110249512-110249513(-) m6A exon//intron       24284625//24981863//27773535
chr9:110249688-110249689(-) m6A CDS//exon//intron       24284625//25456834//24981863//27773535
chr9:110249731-110249732(-) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//27773536
chr9:110249801-110249802(-) m6A CDS//exon//intron       24284625//24981863//27371828//27773536
chr9:110250048-110250049(-) m6A CDS//exon//intron       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr9:110250108-110250109(-) m6A CDS//exon//intron       24284625//25456834//24981863//27371828//27773536//22575960
chr9:110250357-110250358(-) m6A CDS//exon//intron       24284625//24981863
chr9:110250363-110250364(-) m6A CDS//exon//intron       24284625//24981863
chr9:110250388-110250389(-) m6A CDS//exon//intron       24284625//24981863
chr9:110250456-110250457(-) m6A CDS//exon//intron       24284625//24981863
chr9:110250585-110250586(-) m6A exon//intron       24284625
chr9:110251239-110251240(-) m6A CDS//exon       24284625
chr9:110251406-110251407(-) m6A 5'UTR//intron       24284625//27773535
chr9:110251473-110251474(-) m6A 5'UTR//exon       24284625//27773535
chr9:110251616-110251617(-) m6A 5'UTR//exon       24284625//24981863//27773535
chr9:110251634-110251635(-) m6A 5'UTR//exon       24284625//24981863//27773535
chr9:110251689-110251690(-) m6A 5'UTR//exon       24981863//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1304-3p
Exosome Plasma     23663360
Exosome Kidney tissue     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
KLF4
Cytoplasm NSCLC tissue     29665649
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus NSCLC tissue     29665649
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1304-3p
Interactor2: KLF4

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//miRTarBase//miRWalk//Targetscan
Support Database ViRBase

References:


PMID 32232013 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line HUVEC cells Interactor2 expression Upregulation
Description Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).

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