Basic Information:

  VIRBase ID:  

HHID00026360

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1343-3p:  MIMAT0019776          BRIP1:  NM_032043     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1343-3p	BRIP1
miRBase Accession/Entrez ID	MIMAT0019776	83990
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BACH1//FANCJ//OF

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1343-3p	rs1030024806 chr11:34941897    C/T rs1228966720 chr11:34941904    T/G rs1335261302 chr11:34941900    G/A rs568333985 chr11:34941898    C/G rs748356067 chr11:34941908    G/A rs950497159 chr11:34941907    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	BRIP1	chr17:59866272(-) A-I      intronic chr17:59866204(-) A-I      intronic chr17:59766608(-) A-I      intronic chr17:59766569(-) A-I      intronic chr17:59765747(-) A-I      intronic chr17:59765742(-) A-I      intronic chr17:59868263(-) A-I      intronic chr17:59868244(-) A-I      intronic chr17:59905653(-) A-I      intronic chr17:59868215(-) A-I      intronic chr17:59868787(-) A-I      intronic chr17:59868207(-) A-I      intronic chr17:59832820(-) A-I      intronic chr17:59832686(-) A-I      intronic chr17:59831107(-) A-I      intronic chr17:59831091(-) A-I      intronic chr17:59831086(-) A-I      intronic chr17:59831041(-) A-I      intronic chr17:59805372(-) A-I      intronic chr17:59797486(-) A-I      intronic chr17:59797029(-) A-I      intronic chr17:59797023(-) A-I      intronic chr17:59796999(-) A-I      intronic chr17:59796974(-) A-I      intronic chr17:59791437(-) A-I      intronic chr17:59791110(-) A-I      intronic chr17:59790218(-) A-I      intronic chr17:59790213(-) A-I      intronic chr17:59790023(-) A-I      intronic chr17:59790022(-) A-I      intronic chr17:59790010(-) A-I      intronic chr17:59790008(-) A-I      intronic chr17:59789992(-) A-I      intronic chr17:59789778(-) A-I      intronic chr17:59789752(-) A-I      intronic chr17:59789739(-) A-I      intronic chr17:59789731(-) A-I      intronic chr17:59789642(-) A-I      intronic chr17:59769088(-) A-I      intronic chr17:59768928(-) A-I      intronic chr17:59766623(-) A-I      intronic chr17:59766583(-) A-I      intronic chr17:59766553(-) A-I      intronic chr17:59766543(-) A-I      intronic chr17:59766528(-) A-I      intronic chr17:59765828(-) A-I      intronic chr17:59927645(-) A-I      intronic chr17:59927945(-) A-I      intronic chr17:59832837(-) A-I      intronic chr17:59928107(-) A-I      intronic chr17:59928132(-) A-I      intronic chr17:59935003(-) A-I      intronic chr17:59935041(-) A-I      intronic chr17:59923999(-) A-I      intronic chr17:59832838(-) A-I      intronic chr17:59832876(-) A-I      intronic chr17:59832884(-) A-I      intronic chr17:59836125(-) A-I      intronic chr17:59861411(-) A-I      intronic chr17:59866137(-) A-I      intronic chr17:59866169(-) A-I      intronic chr17:59866289(-) A-I      intronic chr17:59867795(-) A-I      intronic chr17:59867798(-) A-I      intronic chr17:59868097(-) A-I      intronic chr17:59868206(-) A-I      intronic chr17:59868259(-) A-I      intronic chr17:59921728(-) A-I      intronic chr17:59869563(-) A-I      intronic chr17:59879665(-) A-I      intronic chr17:59880843(-) A-I      intronic chr17:59880853(-) A-I      intronic chr17:59884227(-) A-I      intronic chr17:59884237(-) A-I      intronic chr17:59888761(-) A-I      intronic chr17:59888763(-) A-I      intronic chr17:59898228(-) A-I      intronic chr17:59898305(-) A-I      intronic chr17:59899011(-) A-I      intronic chr17:59919279(-) A-I      intronic chr17:59919282(-) A-I      intronic chr17:59921517(-) A-I      intronic chr17:59921743(-) A-I      intronic chr17:59921827(-) A-I      intronic chr17:59921868(-) A-I      intronic chr17:59921899(-) A-I      intronic chr17:59923379(-) A-I      intronic chr17:59923774(-) A-I      intronic chr17:59923930(-) A-I      intronic chr17:59927524(-) A-I      intronic chr17:59927531(-) A-I      intronic chr17:59927560(-) A-I      intronic chr17:59927601(-) A-I      intronic chr17:59927624(-) A-I      intronic chr17:59927636(-) A-I      intronic chr17:59760345(-) A-I      3'UTR chr17:59760349(-) A-I      3'UTR chr17:59760330(-) A-I      3'UTR chr17:59757669(-) A-I      3'UTR chr17:59888857(-) A-I      intronic chr17:59866057(-) A-I      intronic chr17:59928126(-) A-I      intronic chr17:59921509(-) A-I      intronic chr17:59790182(-) A-I      intronic chr17:59898989(-) A-I      intronic chr17:59789870(-) A-I      intronic chr17:59888766(-) A-I      intronic chr17:59836273(-) A-I      intronic chr17:59866576(-) A-I      intronic chr17:59888659(-) A-I      intronic chr17:59805090(-) A-I      intronic chr17:59868139(-) A-I      intronic chr17:59921917(-) A-I      intronic chr17:59792504(-) A-I      intronic chr17:59768990(-) A-I      intronic chr17:59867906(-) A-I      intronic chr17:59868072(-) A-I      intronic chr17:59797357(-) A-I      intronic chr17:59879815(-) A-I      intronic chr17:59797358(-) A-I      intronic chr17:59923886(-) A-I      intronic chr17:59923925(-) A-I      intronic chr17:59921795(-) A-I      intronic chr17:59853418(-) A-I      intronic chr17:59921468(-) A-I      intronic chr17:59929998(-) A-I      intronic chr17:59921369(-) A-I      intronic chr17:59791451(-) A-I      intronic chr17:59797359(-) A-I      intronic chr17:59898187(-) A-I      intronic chr17:59928137(-) A-I      intronic chr17:59889056(-) A-I      intronic chr17:59767353(-) A-I      intronic chr17:59868750(-) A-I      intronic chr17:59836309(-) A-I      intronic chr17:59923924(-) A-I      intronic chr17:59768981(-) A-I      intronic chr17:59921469(-) A-I      intronic chr17:59866404(-) A-I      intronic chr17:59869462(-) A-I      intronic chr17:59879603(-) A-I      intronic chr17:59934900(-) A-I      intronic chr17:59790183(-) A-I      intronic chr17:59797263(-) A-I      intronic chr17:59868238(-) A-I      intronic chr17:59866145(-) A-I      intronic chr17:59869549(-) A-I      intronic chr17:59810190(-) A-I      intronic chr17:59888759(-) A-I      intronic chr17:59791499(-) A-I      intronic chr17:59888723(-) A-I      intronic chr17:59884260(-) A-I      intronic chr17:59921508(-) A-I      intronic chr17:59869590(-) A-I      intronic chr17:59767251(-) A-I      intronic chr17:59789769(-) A-I      intronic chr17:59767175(-) A-I      intronic chr17:59780541(-) A-I      intronic chr17:59790141(-) A-I      intronic chr17:59866565(-) A-I      intronic chr17:59921493(-) A-I      intronic chr17:59792326(-) A-I      intronic chr17:59898199(-) A-I      intronic chr17:59868170(-) A-I      intronic chr17:59792291(-) A-I      intronic chr17:59831228(-) A-I      intronic chr17:59789743(-) A-I      intronic chr17:59923915(-) A-I      intronic chr17:59868129(-) A-I      intronic chr17:59888700(-) A-I      intronic chr17:59868767(-) A-I      intronic chr17:59809355(-) A-I      intronic chr17:59767285(-) A-I      intronic chr17:59868079(-) A-I      intronic chr17:59910945(-) A-I      intronic chr17:59867649(-) A-I      intronic chr17:59866516(-) A-I      intronic chr17:59868148(-) A-I      intronic chr17:59928089(-) A-I      intronic chr17:59899225(-) A-I      intronic chr17:59888722(-) A-I      intronic chr17:59910774(-) A-I      intronic chr17:59868254(-) A-I      intronic chr17:59789745(-) A-I      intronic chr17:59789643(-) A-I      intronic chr17:59799074(-) A-I      intronic chr17:59774224(-) A-I      intronic chr17:59831233(-) A-I      intronic chr17:59764549(-) A-I      intronic chr17:59858013(-) A-I      intronic chr17:59923964(-) A-I      intronic chr17:59898987(-) A-I      intronic chr17:59921488(-) A-I      intronic chr17:59810181(-) A-I      intronic chr17:59797470(-) A-I      intronic chr17:59928040(-) A-I      intronic chr17:59910772(-) A-I      intronic chr17:59868751(-) A-I      intronic chr17:59881951(-) A-I      intronic chr17:59757709(-) A-I      3'UTR chr17:59898309(-) A-I      intronic chr17:59928182(-) A-I      intronic chr17:59825175(-) A-I      intronic chr17:59889141(-) A-I      intronic chr17:59884238(-) A-I      intronic chr17:59799196(-) A-I      intronic chr17:59792260(-) A-I      intronic chr17:59921423(-) A-I      intronic chr17:59923926(-) A-I      intronic chr17:59789703(-) A-I      intronic chr17:59899031(-) A-I      intronic chr17:59879705(-) A-I      intronic chr17:59790099(-) A-I      intronic chr17:59907508(-) A-I      intronic chr17:59869557(-) A-I      intronic chr17:59867825(-) A-I      intronic chr17:59790102(-) A-I      intronic chr17:59789768(-) A-I      intronic chr17:59917955(-) A-I      intronic chr17:59809346(-) A-I      intronic chr17:59805305(-) A-I      intronic chr17:59923863(-) A-I      intronic chr17:59927944(-) A-I      intronic chr17:59921888(-) A-I      intronic chr17:59805266(-) A-I      intronic chr17:59790179(-) A-I      intronic chr17:59831023(-) A-I      intronic chr17:59868163(-) A-I      intronic chr17:59789134(-) A-I      intronic chr17:59889116(-) A-I      intronic chr17:59923442(-) A-I      intronic chr17:59907477(-) A-I      intronic chr17:59809357(-) A-I      intronic chr17:59766516(-) A-I      intronic chr17:59911759(-) A-I      intronic chr17:59921829(-) A-I      intronic chr17:59766609(-) A-I      intronic chr17:59888772(-) A-I      intronic chr17:59879637(-) A-I      intronic chr17:59911752(-) A-I      intronic chr17:59796841(-) A-I      intronic chr17:59868116(-) A-I      intronic chr17:59764515(-) A-I      intronic chr17:59898229(-) A-I      intronic chr17:59911763(-) A-I      intronic chr17:59869580(-) A-I      intronic chr17:59905485(-) A-I      intronic chr17:59911760(-) A-I      intronic chr17:59898988(-) A-I      intronic chr17:59889191(-) A-I      intronic chr17:59899042(-) A-I      intronic chr17:59836317(-) A-I      intronic chr17:59921321(-) A-I      intronic chr17:59899066(-) A-I      intronic chr17:59775448(-) A-I      intronic chr17:59869570(-) A-I      intronic chr17:59865247(-) A-I      intronic chr17:59923443(-) A-I      intronic chr17:59868112(-) A-I      intronic chr17:59867844(-) A-I      intronic chr17:59867785(-) A-I      intronic chr17:59765790(-) A-I      intronic chr17:59774539(-) A-I      intronic chr17:59917636(-) A-I      intronic chr17:59921463(-) A-I      intronic chr17:59765659(-) A-I      intronic chr17:59825378(-) A-I      intronic chr17:59921406(-) A-I      intronic chr17:59921400(-) A-I      intronic chr17:59790178(-) A-I      intronic chr17:59911761(-) A-I      intronic chr17:59923362(-) A-I      intronic chr17:59804868(-) A-I      intronic chr17:59868103(-) A-I      intronic chr17:59867824(-) A-I      intronic chr17:59888658(-) A-I      intronic chr17:59888856(-) A-I      intronic chr17:59866380(-) A-I      intronic chr17:59797328(-) A-I      intronic chr17:59911796(-) A-I      intronic chr17:59921417(-) A-I      intronic chr17:59923965(-) A-I      intronic chr17:59829227(-) A-I      intronic chr17:59928106(-) A-I      intronic chr17:59836312(-) A-I      intronic chr17:59797496(-) A-I      intronic chr17:59919321(-) A-I      intronic chr17:59797341(-) A-I      intronic chr17:59927526(-) A-I      intronic chr17:59911783(-) A-I      intronic chr17:59774525(-) A-I      intronic chr17:59928080(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	BRIP1	chr17:59760344(-) G-A exon 3'UTR    21725310 chr17:59789703(-) A-G intron -    22484847 chr17:59791499(-) A-G intron -    22484847 chr17:59843066(-) C-A intron -    22484847 chr17:59869549(-) A-G intron -    22484847 chr17:59888772(-) A-G intron -    22484847 chr17:59927526(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	BRIP1	chr17:59760550-59760551(-) m6A 3'UTR       27773535//22608085 chr17:59760604-59760605(-) m6A 3'UTR       24209618//24981863//27773535//22608085 chr17:59760701-59760702(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr17:59760708-59760709(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr17:59760730-59760731(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr17:59760740-59760741(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr17:59760746-59760747(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr17:59760763-59760764(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr17:59760883-59760884(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr17:59760900-59760901(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr17:59760952-59760953(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr17:59761001-59761002(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr17:59761039-59761040(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr17:59761067-59761068(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr17:59761101-59761102(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr17:59761136-59761137(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr17:59761192-59761193(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr17:59761224-59761225(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr17:59761273-59761274(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr17:59761294-59761295(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr17:59761379-59761380(-) m6A CDS       24284625//24981863//27773535//22608085 chr17:59761421-59761422(-) m6A CDS       24284625//24981863//27773535//22608085 chr17:59762134-59762135(-) m6A 3'UTR//intron       24981863//22608085 chr17:59762140-59762141(-) m6A 3'UTR//intron       24981863//22608085 chr17:59762209-59762210(-) m6A 3'UTR//intron       22608085 chr17:59763266-59763267(-) m6A CDS       24981863//22608085 chr17:59763390-59763391(-) m6A CDS       24981863//22608085 chr17:59763403-59763404(-) m6A CDS       24981863//22608085 chr17:59763408-59763409(-) m6A CDS       24981863//22608085 chr17:59876537-59876538(-) m6A CDS       24981863 chr17:59876601-59876602(-) m6A CDS       24981863 chr17:59876639-59876640(-) m6A CDS       24981863 chr17:59885997-59885998(-) m6A CDS       24209618//24981863//27773535 chr17:59886071-59886072(-) m6A CDS       24981863//27773535 chr17:59886079-59886080(-) m6A CDS       24981863//27773535 chr17:59924480-59924481(-) m6A CDS       24981863//27773535 chr17:59924506-59924507(-) m6A CDS       24981863 chr17:59924514-59924515(-) m6A CDS       24981863 chr17:59924556-59924557(-) m6A CDS       24981863 chr17:59926500-59926501(-) m6A CDS       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1343-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	BRIP1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1343-3p
Interactor2: BRIP1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//miRTarBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32232013	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HUVEC cells	Interactor2 expression	Upregulation
Description	Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).